Protein Alignment dom and rrp1

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_594246.1
• Gene: rrp1 / 2542440
• PomBaseID: SPAC17A2.12
• Length: 897
• Species: Schizosaccharomyces pombe
• Alignment Length: 1202
• Identity: 229/1202 - (19%)
• Similarity: 398/1202 - (33%)
• Gaps: 423/1202 - (35%)

  Fly   735 DFLNDLPP----GYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQE 795
            |.|:..||    ..|:|.::|.:..|         |:.:.|...:..:|...:|.:...|:..:.
pombe     2 DSLSAYPPQSTFQQLQNDEELARRLQ---------DEWNSSSPSSAPSSSSSQNQVELDEQFARS 57

  Fly   796 IDHKKE-------IDELEADNDLSV---------EQLLAKYKSEQPPSPKRRKLAPRD----PEL 840
            :.:.:.       .|...:.|..|.         ::.|..:|:.....|.|....|.:    |.:
pombe    58 LQNSQSSSYSLPPFDHPPSKNPTSSSLSTRKRWRQKRLWSFKNFPFRPPTRLTSTPSNSSSLPSI 122

  Fly   841 DSDDDSTAVDSTEESEDAATEDEEDL---STVKTDTDMEEQ---------DEQEDGLKSLMADAD 893
            .|...:.::.|...:..:.:.|...:   |....|.|..|.         .:|...|.:.:....
pombe   123 PSSSSTPSISSIPHTTSSVSNDIPSVLGSSDHPIDLDNPEHLTPPSSFITAKQLSRLPTPLPPPS 187

  Fly   894 ATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVV---TPVPF-----LLKH--- 947
            ::|...|:.||           |........:||:..|.....::   ||.||     .||:
pombe   188 SSSLPTGTIST-----------NSFCPYERKVQPEHVTKELHQLLQHNTPSPFDTIDLQLKNEQV 241

  Fly   948 -------SLREYQHIGLDWLVTMNE-RKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIV 1004
                   ||..:|..|..|:.:|.: .|..|::||:|||||||||||||............:|||
pombe   242 QSAGLLVSLLPHQVEGHAWMESMEQSSKCGGVMADDMGLGKTIQTIALLLTQKSQDPLRKTNLIV 306

  Fly  1005 VPSSVMLNWEMEFK-KWCPGFKILTY--YGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQ-- 1064
            |..:::..|..|.. |..|..|:..|  :||.|    |.:...:.:.:.|.:|:|.::..:.:
pombe   307 VSVALLHQWAEELSTKVHPSKKLSVYIHHGSTK----KNLDSYELSQYDVVLTTYSMLAYEMKQN 367

  Fly  1065 -----------------SFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQND 1112
                             |.....|..::||||..|:|..:...:..:....:.|..|:|||:||.
pombe   368 DAFNNNNPATATPPPACSLLETSWYRIVLDEAHTIRNRDTLAAKCCVKLDAKYRWCLSGTPIQNH 432

  Fly  1113 LMELWSLMHFL--MPY-VFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKK 1174
            :.|.:||:.||  .|| |:|.   |.:..|.|:...   ..:..|..:.||..::...:.||.|:
pombe   433 IDEFYSLLKFLRIKPYCVWSL---FAKDISRPLKSY---RADIVEAALKRLRILLASTVFRRTKE 491

  Fly  1175 -EVEK----QMPKKYEHVITCRLSNRQRYLYEDFMSRAKT---------RETLQTGNLLSVINVL 1225
             .|..    .:|.|....::..|...:|.||.:.||.|::         .:..:.|.||.   .|
pombe   492 TRVNNLPIVNLPPKTIRTVSVNLLPEERALYNEQMSSAQSLVDNYFNNDHDLSRYGFLLV---SL 553

  Fly  1226 MQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTA 1290
            ::||:.|.||.:.::....:.|
pombe   554 LRLRQFCCHPWLVKSSSLDNSF------------------------------------------- 575

  Fly  1291 YVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLE 1355
                                                  |:|.:|..:    ||.|
pombe   576 --------------------------------------RIRDSENVR----NACK---------- 588

  Fly  1356 GSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLL 1420
                                         :|.|:.|..:.|              |...:.|..|
pombe   589 -----------------------------SLDPLTIERIAT--------------LQDFNCSVCL 610

  Fly  1421 GARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTS 1485
            .       |..|.|           ::.|..:.........|..:...|:||    :|:.|..
pombe   611 D-------PCLAPV-----------FIIPCGHFTCQECMSMLVGQKYGSSST----STIIAKC-- 651

  Fly  1486 GQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAM 1550
              .:.|..||:|  :.|.:|:.:.......:..:.|.:....:..||.|::|.|.|:..:
pombe   652 --PMCRGNIVQD--SLVDATILQAIHGPLNSLKQLELDMNQSFSEQESIKLRWENRIDQM----- 707

  Fly  1551 INRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEER 1615
                                                                     ..|.|.:|
pombe   708 ---------------------------------------------------------FTKKFGKR 715

  Fly  1616 CADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTT 1680
            .::.|.                        ||...|..|.|.:|:...
pombe   716 ASEWKS------------------------SSKLNQARQTILDIIGSK----------------- 739

  Fly  1681 KFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRV 1745
                                       ...::|:::|.::.|.::...|......::|.||:...
pombe   740 ---------------------------RNEKILVYSQFSQYLCLVSHMLKLENIRHVRYDGTMSA 777

  Fly  1746 EQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRD 1810
            .|||..:..||.||.:...::|.::|.||:|||.|:.||..:..:||:::.||.||.||:||.:.
pombe   778 NQRQKSLHSFNNDKDVLVMLVSLKAGSVGLNLTIANHVILQEPFYNPSIEDQAIDRVHRLGQQKP 842

  Fly  1811 VHIYRLVSERTIEVNILKKANQKRMLSDMAIE 1842
            |.:||.:::.|||..|:....:||.|...|::
pombe   843 VTVYRFITKDTIEERIVSVQRKKRQLVKEALD 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727
		HepA	692..>1235	CDD:440319	135/593 (23%)
		DEXQc_SRCAP	949..1171	CDD:350761	69/247 (28%)
		SF2_C_SNF	1685..1817	CDD:350180	37/131 (28%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	45/141 (32%)
		HEC1	<1858..>2031	CDD:444066
		SP1-4_N	2486..>2819	CDD:425404
rrp1	NP_594246.1	HepA	<244..874	CDD:440319	184/938 (20%)
		RING_Ubox	603..663	CDD:473075	16/87 (18%)