DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dom and ssl-1

DIOPT Version :9

Sequence 1:NP_001286676.1 Gene:dom / 45655 FlyBaseID:FBgn0020306 Length:3233 Species:Drosophila melanogaster
Sequence 2:NP_001255179.1 Gene:ssl-1 / 190954 WormBaseID:WBGene00007027 Length:2395 Species:Caenorhabditis elegans


Alignment Length:2622 Identity:850/2622 - (32%)
Similarity:1206/2622 - (45%) Gaps:698/2622 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   488 GTPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPK 552
            |:.|:...:.|:.|||......|       ||:|.:|:.||:||::.|||:..||||..||.|.|
 Worm   180 GSNTAQPSVLPSCGGGETNVERA-------AKREAHVLARIAELRKNGLWSNSRLPKCVEPERNK 237

  Fly   553 AHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIA 617
            .||||||||:.|:|.||..|...|:..||..|..:.|..:||....:||.:.:..:.:::.:.||
 Worm   238 THWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREIKEKRKMCAGIA 302

  Fly   618 REVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSS 682
            :.|:.|||:.:|:|:.:.:..:|.:.::|.::||.|::.|.::.|..:.||:..| :.:||:.|.
 Worm   303 KMVRDFWSSTDKVVDIRAKEVLESRLRKARNKHLMFVIGQVDEMSNIVQEGLVSS-SKSPSIASD 366

  Fly   683 RLTSPKRESDDDFR-PESGSE-DDEETIAKAE--EDAADVKEEVTALAKESEMDFDDFLNDLPPG 743
            |     .:.|::|: |.|.|| |||:|||.||  :...||::||.||..|:.:|.||||..|||.
 Worm   367 R-----DDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATVDMDDFLYTLPPE 426

  Fly   744 YLE------------NRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEI 796
            ||:            .|:||  |||.:                .|||..|:|.        :.||
 Worm   427 YLKAYGLTQEDLEEMKREKL--EEQKA----------------RKEACGDNEE--------KMEI 465

  Fly   797 DHKKEIDELE---ADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDA 858
            |.....|..:   :.:||:.|||                           .|.||.|...:....
 Worm   466 DESPSSDAQKPSTSSSDLTAEQL---------------------------QDPTAEDGNGDGHGV 503

  Fly   859 ATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAE 923
            .    |::..||.::...::.:||                                |.:.|..|.
 Worm   504 L----ENVDYVKLNSQDSDERQQE--------------------------------LANIAEEAL 532

  Fly   924 SLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALL 988
            ..||||.||.:|.|.||||||::..|||||.:||||:||:.|:.||||||||||||||||||:||
 Worm   533 KFQPKGYTLETTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLL 597

  Fly   989 AHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCI 1053
            ||:||::..|||||||||:||:||||||||||||..|||||:|:.|||..||.||.|||.|||||
 Worm   598 AHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAKERAEKRKGWMKPNCFHVCI 662

  Fly  1054 TSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWS 1118
            ||||.|.||.::|:::.|:||||||||||||:||||||.|||....||||||||||||.||||||
 Worm   663 TSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWS 727

  Fly  1119 LMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKK 1183
            |||||||.:||||.:||:|||||:|||:|||||:|..||.|||||:|||:|||||||||||:|:|
 Worm   728 LMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEK 792

  Fly  1184 YEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQ 1248
            .||::.|.||.||||||:|||||..|:|.|::||::||:|::|||||.|||||:||.||.::||.
 Worm   793 TEHIVNCSLSKRQRYLYDDFMSRRSTKENLKSGNMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFV 857

  Fly  1249 MDGITFHTPRLVCDIMEYDP----FTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDI 1309
            ::.:....|..:.:|.:.||    .:||. |..||..:..:.::.:         |.|  |||::
 Worm   858 VEKLQLDVPARLFEISQQDPSSSSASQIP-EIFNLSKIGYQSSVRS---------AKP--LIEEL 910

  Fly  1310 DT-APLPAPRCPN-GKYRFHIRVRSAELAQRIKLNAVKVGASP-AMRLEGSKIMPMRNLLPSGRV 1371
            :. :..|.||.|. |.:||:   |:|.:|:           :| ....|...:|..| :||    
 Worm   911 EAMSTYPEPRAPEVGGFRFN---RTAFVAK-----------NPHTEESEDEGVMRSR-VLP---- 956

  Fly  1372 LKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAK 1436
                    .|:|...:|:       ...:|...::|....:....||.:     :|.     |..
 Worm   957 --------KPINGTAQPL-------QNGNSIPQNAPNRPQTSCIRSKTV-----VNT-----VPL 996

  Fly  1437 TMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATH 1501
            |:...:..|:...| |.|....||    ..:|..|....|..:|.:.|:....:...:|:.:...
 Worm   997 TISTDRSGFHFNMA-NVGRGVVRL----DDSARMSPPLKRQKLTGTATNWSDYVPRHVVEKMEES 1056

  Fly  1502 VKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMA-----MINRRRTDATPI 1561
            .|:.::   |...:.|     ....|....|::.:.:|:.:|...|:|     ::..|..     
 Worm  1057 RKNQLE---IVRRRFE-----MIRAPIIPLEMVALVREEIIAEFPRLAVEEDEVVQERLL----- 1108

  Fly  1562 YGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANF 1626
              |.|...:||.......:....||.|..::...:....|       |.:.|.....|       
 Worm  1109 --EYCELLVQRFGMYVEPVLTDAWQCRPSSSGLPSYIRNN-------LSNIELNSRSL------- 1157

  Fly  1627 VIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYD 1691
                              |.:|....:.|:.  :.:||                :||:.|||:||
 Worm  1158 ------------------LLNTSTNFDTRMS--ISRAL----------------QFPELRLIEYD 1186

  Fly  1692 CGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFN 1756
            ||||||:..|||||.:..||.||||||:||||||:.||::||:.|.||||:|.|||||.:|||||
 Worm  1187 CGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFN 1251

  Fly  1757 GDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERT 1821
            .|.::|||||||||||||:||||||||||||||||||||||||||||||||||:|.||||:||||
 Worm  1252 ADPKVFCFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERT 1316

  Fly  1822 IEVNILKKANQKRMLSDMAIEGGNFTTTYFK-SSTIKDLFTMEQSEQDESSQEKSENKDRIVATT 1885
            ||.|||:||.|||.|.::||:...||..:|| |.:|:|||..|.                 |..|
 Worm  1317 IEENILRKATQKRRLGELAIDEAGFTPEFFKQSDSIRDLFDGEN-----------------VEVT 1364

  Fly  1886 TLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDE-NIPIATEDPNAE 1949
            .::|..:|:.|.|      .|.|:|..|||.||.|.|.|.||...|.||||| ::|..:   |.:
 Worm  1365 AVADVATTMSEKE------MEVAMAKCEDEADVNAAKIAVAEANVDNAEFDEKSLPPMS---NLQ 1420

  Fly  1950 GGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEAN---- 2010
            |.     .:||.:...|::||.||||||:.|:|........|:.:.|||.::.::.||:.|    
 Worm  1421 GD-----EEADEKYMELIQQLKPIERYAINFLETQYKPEFEEECKEAEALIDQKREEWDKNLNDT 1480

  Fly  2011 RLAAMHKEEELLKQE--TEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYI-- 2071
            .:..:...:.||..:  |.|:   .|......:::.......:.||:|.||:|| |:|.|..:  
 Worm  1481 AVIDLDDSDSLLLNDPSTSAD---FYQSSSLLDEIKFYDELDDIMPIWLPPSPP-DSDADFDLRM 1541

  Fly  2072 -DYSLSFMYELEPIAETDLPPV-------YVRKEHKRSRTDA------------GYDGSRRPNKM 2116
             |..|..|||:|.:.|..||.|       ...|:.|::..:|            .||...:..:|
 Worm  1542 EDDCLDLMYEIEQMNEARLPQVCHEMRRPLAEKQQKQNTLNAFNDILSAKEKESVYDAVNKCLQM 1606

  Fly  2117 RR--------------------------EDNYVPPRSLFD--RPT---------PQLARLRRELK 2144
            .:                          :|..:.| ||.:  :||         ||..:.:::.|
 Worm  1607 PQSEAITAESAASPAYTEHSSFSMDDTSQDAKIEP-SLTENQQPTTTATTTTTVPQQQQQQQQQK 1670

  Fly  2145 SQRFR--------------GSFKPNMPIPGLKPQLPTKPLTEPE-AMAEWCVFEDMAILHVLVNL 2194
            |.:.:              |..:...|.|..:        .||: ..|||.:.||.|:|.. |.:
 Worm  1671 SSKKKRNDNRTAQNRTAENGVKRATTPPPSWR--------EEPDYDGAEWNIVEDYALLQA-VQV 1726

  Fly  2195 QGLPCSLMLLS--PGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKK 2257
            :.....|:..|  .|...||:.||..||..::.:||||||..||:..::|:|.|::|.|....||
 Worm  1727 EFANAHLVEKSANEGMVLNWEFVSNAVNKQTRFFRSARQCSIRYQMFVRPKELGQLVASDPISKK 1791

  Fly  2258 LKPTLRTEYLKSPLRYLR-----TTQLYVSDNNASFYKTMRSRFDSIKTAYLK------KAPPPK 2311
               |::.:...:.|.:||     |...|..|......|...:||.|::.|..:      :.|...
 Worm  1792 ---TMKVDLSHTELSHLRKGRMTTESQYAHDYGILTDKKHVNRFKSVRVAATRRPVQFWRGPKAL 1853

  Fly  2312 RQFSAPSL---MNPKHMEVLQEFGI---LNYDQ----PVSPQNIAAMKANKIR------------ 2354
            ...:..||   |.|:|...|.||.:   :..|.    .:|.::|.|.:|:|.:            
 Worm  1854 ESRNLQSLNGGMPPRHESRLAEFDVKTNIRLDAEDIVTMSDESIVAYEASKKKLLASRQTKPSPR 1918

  Fly  2355 ------------------------EKQRGQQMSQPPV---------------------------- 2367
                                    ..:|..:::.||:                            
 Worm  1919 QDVRFHTLVLRPYTVPVTTEYSAAPSRREMRIAVPPLQPSALSTISSVAAAATSGPLPSIQHLQS 1983

  Fly  2368 ---GVGVVQQMQQQSQQQQQ-------------PAPPPLPQQQ------------------QPQQ 2398
               |:|..|.:|.....:|:             ...||:|.:|                  :| |
 Worm  1984 SSTGLGSQQNLQNSHNSEQRNNVQNMHQNQYNSSQNPPIPIRQIGAASSHQHDQGSQGPGGKP-Q 2047

  Fly  2399 VVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQ--- 2460
            ....|||..|||||||||..:|::                             .|..|||..   
 Worm  2048 AYHLVQQGSQQQQQQQQQATLQRR-----------------------------NAAAAAGSNVQF 2083

  Fly  2461 LQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTAGQLQQL 2525
            :||.|.|..:..|...||...::    ..|..::.||||.|....      |...|....|.||.
 Worm  2084 IQQQQQQQQSGKNCGQGQSFVVM----GSQSSSNDGQGGASTVGG------GGGGSQQPHQQQQQ 2138

  Fly  2526 AQQSAV----------------ASGGQSSVSVV-----LTTPVQTLPSVVQPQIGSGAQIVSISS 2569
            ..|..:                ..||..|..|:     :..|..|||       |.|...|..:.
 Worm  2139 QPQQRIQYIPQVTGSGNNGGGGGRGGYGSTLVMPRGGRVVRPAGTLP-------GGGRLYVDHNR 2196

  Fly  2570 QTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTLNTTMLRGQRI 2634
            ...|::|:              ||.|..||         |.|..||.           |:.|||.
 Worm  2197 HPYPMSSN--------------VVPVRVLP---------ATQQGQQR-----------MMTGQRR 2227

  Fly  2635 VSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQTTQLVTTKGIPVSA 2699
            .:.|.|..          :.:.:||.|.|..|     |:|                        :
 Worm  2228 PAPAPGTV----------AAMVLPNRGAGGIP-----QMR------------------------S 2253

  Fly  2700 LQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPSGSAGATGATANLVQAG-------- 2756
            ||:|..|        .||.      |:.:.|: ...|.:.|.:.|..|....| |.|        
 Worm  2254 LQRGSYT--------GGGG------QQRINVM-VQPQQMRSNNGGGVGGQGGL-QGGPGGPQGIR 2302

  Fly  2757 ----GTIIQ--ASNMATHVTSQKVAVSGMPGTSTTVQAGNVVS-----SVQM----HGQARTQFI 2806
                |..:|  ..|.|.  |..:|.|:...|.....|...|:.     |:||    |.|.:.|..
 Worm  2303 RPLVGRPLQRGVDNQAP--TVAQVVVAPPQGMQQASQGPPVLHMQRAVSMQMPTSHHHQGQQQAP 2365

  Fly  2807 KQMAAGKQQLQRQVVSADGTTT 2828
            .|   ..||..:|..::|..|:
 Worm  2366 PQ---SSQQASQQAPTSDSGTS 2384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
domNP_001286676.1 HSA 543..614 CDD:214727 28/70 (40%)
ASF1_hist_chap <674..831 CDD:304562 55/175 (31%)
FAM176 <824..>868 CDD:291517 5/43 (12%)
SNF2_N 952..1238 CDD:278600 209/285 (73%)
DEXDc 969..1108 CDD:238005 104/138 (75%)
Helicase_C 1692..1806 CDD:278689 88/113 (78%)
ssl-1NP_001255179.1 HSA 231..296 CDD:284861 26/64 (41%)
VID27 <249..>376 CDD:227496 38/132 (29%)
SNF2_N 561..847 CDD:278600 209/285 (73%)
DEXDc 578..717 CDD:238005 104/138 (75%)
Helicase_C 1187..1301 CDD:278689 88/113 (78%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160164594
Domainoid 1 1.000 443 1.000 Domainoid score I275
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1008 1.000 Inparanoid score I144
Isobase 1 0.950 - 0 Normalized mean entropy S4880
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188211at2759
OrthoFinder 1 1.000 - - FOG0001654
OrthoInspector 1 1.000 - - oto17990
orthoMCL 1 0.900 - - OOG6_101779
Panther 1 1.100 - - LDO PTHR45685
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1426
SonicParanoid 1 1.000 - - X2889
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.970

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