Protein Alignment dom and ssl-1

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_001255179.1
• Gene: ssl-1 / 190954
• WormBaseID: WBGene00007027
• Length: 2395
• Species: Caenorhabditis elegans
• Alignment Length: 2622
• Identity: 850/2622 - (32%)
• Similarity: 1206/2622 - (45%)
• Gaps: 698/2622 - (26%)

  Fly   488 GTPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPK 552
            |:.|:...:.|:.|||......|       ||:|.:|:.||:||::.|||:..||||..||.|.|
 Worm   180 GSNTAQPSVLPSCGGGETNVERA-------AKREAHVLARIAELRKNGLWSNSRLPKCVEPERNK 237

  Fly   553 AHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIA 617
            .||||||||:.|:|.||..|...|:..||..|..:.|..:||....:||.:.:..:.:::.:.||
 Worm   238 THWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREIKEKRKMCAGIA 302

  Fly   618 REVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSS 682
            :.|:.|||:.:|:|:.:.:..:|.:.::|.::||.|::.|.::.|..:.||:..| :.:||:.|.
 Worm   303 KMVRDFWSSTDKVVDIRAKEVLESRLRKARNKHLMFVIGQVDEMSNIVQEGLVSS-SKSPSIASD 366

  Fly   683 RLTSPKRESDDDFR-PESGSE-DDEETIAKAE--EDAADVKEEVTALAKESEMDFDDFLNDLPPG 743
            |     .:.|::|: |.|.|| |||:|||.||  :...||::||.||..|:.:|.||||..|||.
 Worm   367 R-----DDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATVDMDDFLYTLPPE 426

  Fly   744 YLE------------NRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEI 796
            ||:            .|:||  |||.:                .|||..|:|.        :.||
 Worm   427 YLKAYGLTQEDLEEMKREKL--EEQKA----------------RKEACGDNEE--------KMEI 465

  Fly   797 DHKKEIDELE---ADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDA 858
            |.....|..:   :.:||:.|||                           .|.||.|...:....
 Worm   466 DESPSSDAQKPSTSSSDLTAEQL---------------------------QDPTAEDGNGDGHGV 503

  Fly   859 ATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAE 923
            .    |::..||.::...::.:||                                |.:.|..|.
 Worm   504 L----ENVDYVKLNSQDSDERQQE--------------------------------LANIAEEAL 532

  Fly   924 SLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALL 988
            ..||||.||.:|.|.||||||::..|||||.:||||:||:.|:.||||||||||||||||||:||
 Worm   533 KFQPKGYTLETTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLL 597

  Fly   989 AHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCI 1053
            ||:||::..|||||||||:||:||||||||||||..|||||:|:.|||..||.||.|||.|||||
 Worm   598 AHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAKERAEKRKGWMKPNCFHVCI 662

  Fly  1054 TSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWS 1118
            ||||.|.||.::|:::.|:||||||||||||:||||||.|||....||||||||||||.||||||
 Worm   663 TSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWS 727

  Fly  1119 LMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKK 1183
            |||||||.:||||.:||:|||||:|||:|||||:|..||.|||||:|||:|||||||||||:|:|
 Worm   728 LMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEK 792

  Fly  1184 YEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQ 1248
            .||::.|.||.||||||:|||||..|:|.|::||::||:|::|||||.|||||:||.||.::||.
 Worm   793 TEHIVNCSLSKRQRYLYDDFMSRRSTKENLKSGNMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFV 857

  Fly  1249 MDGITFHTPRLVCDIMEYDP----FTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDI 1309
            ::.:....|..:.:|.:.||    .:||. |..||..:..:.::.:         |.|  |||::
 Worm   858 VEKLQLDVPARLFEISQQDPSSSSASQIP-EIFNLSKIGYQSSVRS---------AKP--LIEEL 910

  Fly  1310 DT-APLPAPRCPN-GKYRFHIRVRSAELAQRIKLNAVKVGASP-AMRLEGSKIMPMRNLLPSGRV 1371
            :. :..|.||.|. |.:||:   |:|.:|:           :| ....|...:|..| :||
 Worm   911 EAMSTYPEPRAPEVGGFRFN---RTAFVAK-----------NPHTEESEDEGVMRSR-VLP---- 956

  Fly  1372 LKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAK 1436
                    .|:|...:|:       ...:|...::|....:....||.:     :|.     |..
 Worm   957 --------KPINGTAQPL-------QNGNSIPQNAPNRPQTSCIRSKTV-----VNT-----VPL 996

  Fly  1437 TMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATH 1501
            |:...:..|:...| |.|....||    ..:|..|....|..:|.:.|:....:...:|:.:...
 Worm   997 TISTDRSGFHFNMA-NVGRGVVRL----DDSARMSPPLKRQKLTGTATNWSDYVPRHVVEKMEES 1056

  Fly  1502 VKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMA-----MINRRRTDATPI 1561
            .|:.::   |...:.|     ....|....|::.:.:|:.:|...|:|     ::..|..
 Worm  1057 RKNQLE---IVRRRFE-----MIRAPIIPLEMVALVREEIIAEFPRLAVEEDEVVQERLL----- 1108

  Fly  1562 YGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANF 1626
              |.|...:||.......:....||.|..::...:....|       |.:.|.....|
 Worm  1109 --EYCELLVQRFGMYVEPVLTDAWQCRPSSSGLPSYIRNN-------LSNIELNSRSL------- 1157

  Fly  1627 VIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYD 1691
                              |.:|....:.|:.  :.:||                :||:.|||:||
 Worm  1158 ------------------LLNTSTNFDTRMS--ISRAL----------------QFPELRLIEYD 1186

  Fly  1692 CGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFN 1756
            ||||||:..|||||.:..||.||||||:||||||:.||::||:.|.||||:|.|||||.:|||||
 Worm  1187 CGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFN 1251

  Fly  1757 GDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERT 1821
            .|.::|||||||||||||:||||||||||||||||||||||||||||||||||:|.||||:||||
 Worm  1252 ADPKVFCFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERT 1316

  Fly  1822 IEVNILKKANQKRMLSDMAIEGGNFTTTYFK-SSTIKDLFTMEQSEQDESSQEKSENKDRIVATT 1885
            ||.|||:||.|||.|.::||:...||..:|| |.:|:|||..|.                 |..|
 Worm  1317 IEENILRKATQKRRLGELAIDEAGFTPEFFKQSDSIRDLFDGEN-----------------VEVT 1364

  Fly  1886 TLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDE-NIPIATEDPNAE 1949
            .::|..:|:.|.|      .|.|:|..|||.||.|.|.|.||...|.||||| ::|..:   |.:
 Worm  1365 AVADVATTMSEKE------MEVAMAKCEDEADVNAAKIAVAEANVDNAEFDEKSLPPMS---NLQ 1420

  Fly  1950 GGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEAN---- 2010
            |.     .:||.:...|::||.||||||:.|:|........|:.:.|||.::.::.||:.|
 Worm  1421 GD-----EEADEKYMELIQQLKPIERYAINFLETQYKPEFEEECKEAEALIDQKREEWDKNLNDT 1480

  Fly  2011 RLAAMHKEEELLKQE--TEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYI-- 2071
            .:..:...:.||..:  |.|:   .|......:::.......:.||:|.||:|| |:|.|..:
 Worm  1481 AVIDLDDSDSLLLNDPSTSAD---FYQSSSLLDEIKFYDELDDIMPIWLPPSPP-DSDADFDLRM 1541

  Fly  2072 -DYSLSFMYELEPIAETDLPPV-------YVRKEHKRSRTDA------------GYDGSRRPNKM 2116
             |..|..|||:|.:.|..||.|       ...|:.|::..:|            .||...:..:|
 Worm  1542 EDDCLDLMYEIEQMNEARLPQVCHEMRRPLAEKQQKQNTLNAFNDILSAKEKESVYDAVNKCLQM 1606

  Fly  2117 RR--------------------------EDNYVPPRSLFD--RPT---------PQLARLRRELK 2144
            .:                          :|..:.| ||.:  :||         ||..:.:::.|
 Worm  1607 PQSEAITAESAASPAYTEHSSFSMDDTSQDAKIEP-SLTENQQPTTTATTTTTVPQQQQQQQQQK 1670

  Fly  2145 SQRFR--------------GSFKPNMPIPGLKPQLPTKPLTEPE-AMAEWCVFEDMAILHVLVNL 2194
            |.:.:              |..:...|.|..:        .||: ..|||.:.||.|:|.. |.:
 Worm  1671 SSKKKRNDNRTAQNRTAENGVKRATTPPPSWR--------EEPDYDGAEWNIVEDYALLQA-VQV 1726

  Fly  2195 QGLPCSLMLLS--PGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKK 2257
            :.....|:..|  .|...||:.||..||..::.:||||||..||:..::|:|.|::|.|....||
 Worm  1727 EFANAHLVEKSANEGMVLNWEFVSNAVNKQTRFFRSARQCSIRYQMFVRPKELGQLVASDPISKK 1791

  Fly  2258 LKPTLRTEYLKSPLRYLR-----TTQLYVSDNNASFYKTMRSRFDSIKTAYLK------KAPPPK 2311
               |::.:...:.|.:||     |...|..|......|...:||.|::.|..:      :.|...
 Worm  1792 ---TMKVDLSHTELSHLRKGRMTTESQYAHDYGILTDKKHVNRFKSVRVAATRRPVQFWRGPKAL 1853

  Fly  2312 RQFSAPSL---MNPKHMEVLQEFGI---LNYDQ----PVSPQNIAAMKANKIR------------ 2354
            ...:..||   |.|:|...|.||.:   :..|.    .:|.::|.|.:|:|.:
 Worm  1854 ESRNLQSLNGGMPPRHESRLAEFDVKTNIRLDAEDIVTMSDESIVAYEASKKKLLASRQTKPSPR 1918

  Fly  2355 ------------------------EKQRGQQMSQPPV---------------------------- 2367
                                    ..:|..:::.||:
 Worm  1919 QDVRFHTLVLRPYTVPVTTEYSAAPSRREMRIAVPPLQPSALSTISSVAAAATSGPLPSIQHLQS 1983

  Fly  2368 ---GVGVVQQMQQQSQQQQQ-------------PAPPPLPQQQ------------------QPQQ 2398
               |:|..|.:|.....:|:             ...||:|.:|                  :| |
 Worm  1984 SSTGLGSQQNLQNSHNSEQRNNVQNMHQNQYNSSQNPPIPIRQIGAASSHQHDQGSQGPGGKP-Q 2047

  Fly  2399 VVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQ--- 2460
            ....|||..|||||||||..:|::                             .|..|||..
 Worm  2048 AYHLVQQGSQQQQQQQQQATLQRR-----------------------------NAAAAAGSNVQF 2083

  Fly  2461 LQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTAGQLQQL 2525
            :||.|.|..:..|...||...::    ..|..::.||||.|....      |...|....|.||.
 Worm  2084 IQQQQQQQQSGKNCGQGQSFVVM----GSQSSSNDGQGGASTVGG------GGGGSQQPHQQQQQ 2138

  Fly  2526 AQQSAV----------------ASGGQSSVSVV-----LTTPVQTLPSVVQPQIGSGAQIVSISS 2569
            ..|..:                ..||..|..|:     :..|..|||       |.|...|..:.
 Worm  2139 QPQQRIQYIPQVTGSGNNGGGGGRGGYGSTLVMPRGGRVVRPAGTLP-------GGGRLYVDHNR 2196

  Fly  2570 QTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTLNTTMLRGQRI 2634
            ...|::|:              ||.|..||         |.|..||.           |:.|||.
 Worm  2197 HPYPMSSN--------------VVPVRVLP---------ATQQGQQR-----------MMTGQRR 2227

  Fly  2635 VSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQTTQLVTTKGIPVSA 2699
            .:.|.|..          :.:.:||.|.|..|     |:|                        :
 Worm  2228 PAPAPGTV----------AAMVLPNRGAGGIP-----QMR------------------------S 2253

  Fly  2700 LQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPSGSAGATGATANLVQAG-------- 2756
            ||:|..|        .||.      |:.:.|: ...|.:.|.:.|..|....| |.|
 Worm  2254 LQRGSYT--------GGGG------QQRINVM-VQPQQMRSNNGGGVGGQGGL-QGGPGGPQGIR 2302

  Fly  2757 ----GTIIQ--ASNMATHVTSQKVAVSGMPGTSTTVQAGNVVS-----SVQM----HGQARTQFI 2806
                |..:|  ..|.|.  |..:|.|:...|.....|...|:.     |:||    |.|.:.|..
 Worm  2303 RPLVGRPLQRGVDNQAP--TVAQVVVAPPQGMQQASQGPPVLHMQRAVSMQMPTSHHHQGQQQAP 2365

  Fly  2807 KQMAAGKQQLQRQVVSADGTTT 2828
            .|   ..||..:|..::|..|:
 Worm  2366 PQ---SSQQASQQAPTSDSGTS 2384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	28/70 (40%)
		HepA	692..>1235	CDD:440319	286/561 (51%)
		DEXQc_SRCAP	949..1171	CDD:350761	166/221 (75%)
		SF2_C_SNF	1685..1817	CDD:350180	102/131 (78%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	140/234 (60%)
		HEC1	<1858..>2031	CDD:444066	56/179 (31%)
		SP1-4_N	2486..>2819	CDD:425404	81/376 (22%)
ssl-1	NP_001255179.1	HSA	231..295	CDD:462194	26/63 (41%)
		PLN03142	372..>851	CDD:215601	290/567 (51%)
		DEXQc_SRCAP	558..780	CDD:350761	166/221 (75%)
		SF2_C_SNF	1183..1312	CDD:350180	100/128 (78%)
		Med15	1978..>2359	CDD:312941	111/518 (21%)