Protein Alignment dom and swsn-4

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_502082.1
• Gene: swsn-4 / 178015
• WormBaseID: WBGene00004204
• Length: 1474
• Species: Caenorhabditis elegans
• Alignment Length: 2229
• Identity: 469/2229 - (21%)
• Similarity: 752/2229 - (33%)
• Gaps: 915/2229 - (41%)

  Fly   347 SATSAEASGNVLAVEAEIKIPAVGATPVAIS-TKLPAAVVQLTQQG------H------------ 392
            :|...:.:|.|:|.:|     ..||....:: :||..|:..:.:||      |
 Worm    11 TAQPPQPAGEVVAQQA-----GDGAQGQELTISKLENAITSMEEQGLQNDHRHAKAVLLKQKLQS 70

  Fly   393 -----IPGRPLGGRHGMVFGQIPAPPAAVG-------NPSVP--LVPGGTPLLPCNTSAGSTALR 443
                 :||:..||...:...|:....|.|.       |..||  |:.....|.|..|    |.|.
 Worm    71 GLPDAVPGQENGGNQQITPAQLNQLRAQVSAYRLLARNEQVPANLIADAVMLRPKVT----TLLP 131

  Fly   444 RP-----QGQNNASSGSAAASGGGGSLTPTPL--------YTGNGPAALGGSGGLTP--GTPTSG 493
            .|     :.:|             |...|..|        ...|.|..:....|:.|  ......
 Worm   132 EPYEYPGEAEN-------------GEKLPYDLMKIFNLHQIRCNRPTTISVPSGIDPVGMLKQRE 183

  Fly   494 SLLSPALGGG----SGTPNSAAQEFSFKAKQEVYVMQRI-------SEL---------------- 531
            :::...:|..    :..|.........||:.|:..::.:       ||:
 Worm   184 NMIQNRIGLRMKLLNNLPADIPDHMKLKAEIELRALRLVNLQTQVRSEVMACLKRDTTLETALNP 248

  Fly   532 ------QREGLWTERRLPKL-------QEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKC 583
                  :|:.|...|...||       ||..|.:.|.| |::.::....:|   :::.:|...|.
 Worm   249 YAYRRTKRQSLREARVTEKLEKQQKMEQERKRRQKHTD-LMQAIIQHGKEF---KEYHRNNLLKM 309

  Fly   584 A---KMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLV---EYKHQTKIEEK 642
            |   |.|..|.|:.    :|..|..|::.:::             .::||:   |..::..::||
 Worm   310 AKSRKAVMTYHQNN----ERERKKDEIRNEKL-------------RMQKLMQEDEEGYRALLDEK 357

  Fly   643 RKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEET 707
            :    ||.|.:::.||:::...|.           ||......:.|::..:|.:.|.|::.|||.
 Worm   358 K----DQRLVYLLQQTDEYVDSLC-----------SLVRQHQNTEKKKKKEDKKIEKGNQMDEEA 407

  Fly   708 IAKAEEDAADVKEEVTALA-------KESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETP 765
                   ...|:|..|..|       |..|::|  :|...|...:..||:|
 Worm   408 -------RVHVRERSTGKALTGDQAPKTEEIEF--WLETHPEYEIVPRDQL-------------- 449

  Fly   766 DDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKR 830
                         |||       :||.|:|
 Worm   450 -------------SDD-------EEEEEEE----------------------------------- 459

  Fly   831 RKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADAT 895
               ||.:||.:.||....:            |||..:.:..:....|:||.:...|..|||..||
 Worm   460 ---APVEPEEEKDDQYAGM------------DEETKAKMILEKARNEEDEYDQKTKKQMADYYAT 509

  Fly   896 SGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWL 960
                                  |..:.|.:..:..|:...:     |.||   |:.||..||:|:
 Worm   510 ----------------------AHKIKEKVVKQHTTMGGGD-----PNLL---LKPYQIKGLEWM 544

  Fly   961 VTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFK 1025
            |::....||||||||||||||||||:|:.:|...|.|.||:|::||.|.:.||:.||.||.|...
 Worm   545 VSLYNNNLNGILADEMGLGKTIQTISLVTYLMEVKQNNGPYLVIVPLSTLSNWQNEFAKWAPSVT 609

  Fly  1026 ILTYYGSQKERKLKRV-GWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQR 1089
            .:.|.|::..|  :|| |..:..||:|.:|:|:.|::::....:.:|||:|:||...:||... :
 Worm   610 TIIYKGTKDAR--RRVEGQIRKGAFNVLMTTYEYVIKEKALLGKIRWKYMIIDEGHRLKNHNC-K 671

  Fly  1090 WQLLLN--FSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPM--TG-MIEGN 1149
            ..|:||  |..:.|||||||||||.|.|||:|::||:|.:|||...|::||:.|.  || .:|.|
 Worm   672 LTLMLNGFFHAQHRLLLTGTPLQNKLPELWALLNFLLPSIFSSCGTFEQWFNAPFATTGEKVELN 736

  Fly  1150 MEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQ 1214
            .|....:|.|||||:|||||||||||||.|:|.|.|:||.|..|..|:.:|. .|.:....:...
 Worm   737 QEETMLIIRRLHKVLRPFLLRRLKKEVESQLPDKTEYVIKCDQSALQKVIYR-HMQKGLLLDAKM 800

  Fly  1215 TGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNL 1279
            :....|::|.::.|||:||||.:|.
 Worm   801 SSGARSLMNTVVHLRKLCNHPFLFP---------------------------------------- 825

  Fly  1280 LLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAV 1344
               ::|.:..||
 Worm   826 ---NIEDSCRAY----------------------------------------------------- 834

  Fly  1345 KVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTG 1409
                                                                             
 Worm   835 ----------------------------------------------------------------- 834

  Fly  1410 ALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTT 1474
                                                                             
 Worm   835 ----------------------------------------------------------------- 834

  Fly  1475 SRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKE 1539
                                                                 :||.|:
 Worm   835 -----------------------------------------------------WKVNEV------ 840

  Fly  1540 QRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWS 1604
                                                                         ||
 Worm   841 -------------------------------------------------------------NG-- 842

  Fly  1605 LNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLA 1669
                        .||..|
 Worm   843 ------------TDLMRV----------------------------------------------- 848

  Fly  1670 LLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGH 1734
                                  .|||:.:||:|.:||..|||:|:|.|||.|:::.|.|||:..:
 Worm   849 ----------------------AGKLELLDRILPKLKATGHRILMFFQMTSMMNIFEDFLNFRRY 891

  Fly  1735 IYLRLDGSTRVEQRQILMERFNG-DKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQA 1798
            .||||||||:.::|..|:.:||. :..:|.|:||||:||:|:||..|||||.:||||||..|.||
 Worm   892 TYLRLDGSTKPDERGDLLTQFNAPNSDLFLFMLSTRAGGLGLNLQTADTVIIFDSDWNPHQDMQA 956

  Fly  1799 QDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTME 1863
            |||.|||||.::|.:.||::..::|..||..|..|..:.:..|:.|.|
 Worm   957 QDRAHRIGQKKEVRVLRLITANSVEEKILAAARYKLNVDEKVIQAGKF----------------- 1004

  Fly  1864 QSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEV 1928
                                     |..||..| .||.|.....|....|:|::|...:|....|
 Worm  1005 -------------------------DQRSTGAE-RKQMLEQIIQADGEEEEEEEVPDDETVNQMV 1043

  Fly  1929 AADLAEFD--ENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAE 1991
            |....||:  :::.|   |...|...|:......||...:     |.:...:.|..|       |
 Worm  1044 ARSEEEFNIFQSMDI---DRRREEANQLHRKPRLLEEHEI-----PDDILKLSFDYE-------E 1093

  Fly  1992 QLRAAEAELEA-------QKREWEANRLAAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNT 2049
            ..||.|...|.       ::|..|.:..:.:..:|:.:||..|.|        |.:||....|..
 Worm  1094 MERAREEGREVVDQTPNQRRRRREVDYSSDLLSDEQFMKQVEEVE--------DENNQAVAERKK 1150

  Fly  2050 MEQMPMWCPPTPPQDNDNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPN 2114
            ..:..|     ...|.::|...|..|                     :||:.:||.  :.:.:.|
 Worm  1151 QRKRKM-----AGLDENDDSMDDVVL---------------------QHKKKKTDP--ELAEKIN 1187

  Fly  2115 KM-------RREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTE 2172
            :|       :.||..:........||      |:||... ::...|| |....:..::.|...|.
 Worm  1188 EMLDVILEYKNEDGELIADVFQTLPT------RKELPDY-YQVISKP-MDFDRINKKIETGRYTV 1244

  Fly  2173 PEAMAEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQC--RWR 2235
            .|.:.     :||       ||        |::..||.|.:        .|:.|.|:...  .|:
 Worm  1245 MEELN-----DDM-------NL--------LVNNAQTYNEE--------GSEIYVSSETIGKLWK 1281

  Fly  2236 --YETHIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDS 2298
              |:..:.|   .|.||.|.|:|  :|:..:   .|..|...:....|||...:...|.:...
 Worm  1282 EQYDKFMNP---PKPVEEPVKKK--EPSTPS---TSSSRPSTSGTPSVSDLQRTQQATAQQML-- 1336

  Fly  2299 IKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFG----ILNYDQPVSPQNIAAMKANKIREKQRG 2359
            :...:::..||.:.|....:||.       |..|    :|.|.|...... .|..:.|:..|:..
 Worm  1337 MLMTHMQSLPPAQAQQFQQALMT-------QTGGNQALMLQYMQSAMLAQ-RAQASTKVTPKKDE 1393

  Fly  2360 QQMSQPPVGVGVVQQMQQQSQQQQQP------APPPLPQQQQPQQVVQQVQQQQQQQQQQQQQQV 2418
            ::.:...|       ..:::::..:|      ||||..:::.        :..:...::.:::::
 Worm  1394 KKETSSSV-------KTEEAKKDDEPSTSSASAPPPKKKKES--------EDSEDPMEEDEEEEI 1443

  Fly  2419 VQQQLPTVSNVQQTLPVQQ 2437
            :.|:....|:.:::.|.::
 Worm  1444 IGQKKEPASSRRKSRPTRR 1462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	19/80 (24%)
		HepA	692..>1235	CDD:440319	183/555 (33%)
		DEXQc_SRCAP	949..1171	CDD:350761	108/227 (48%)
		SF2_C_SNF	1685..1817	CDD:350180	68/132 (52%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	87/234 (37%)
		HEC1	<1858..>2031	CDD:444066	37/181 (20%)
		SP1-4_N	2486..>2819	CDD:425404
swsn-4	NP_502082.1	QLQ	88..116	CDD:462622	6/27 (22%)
		HSA	272..344	CDD:214727	19/92 (21%)
		BRK	403..446	CDD:462196	12/51 (24%)
		PLN03142	472..1288	CDD:215601	321/1420 (23%)