Protein Alignment dom and btf-1

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_496802.2
• Gene: btf-1 / 174965
• WormBaseID: WBGene00000274
• Length: 1649
• Species: Caenorhabditis elegans
• Alignment Length: 1451
• Identity: 272/1451 - (18%)
• Similarity: 439/1451 - (30%)
• Gaps: 671/1451 - (46%)

  Fly   581 KKCAKMVQ----KYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEE 641
            |.|.:.::    :.| |:.:|..|.|..:::. |...|.:...:|:                  |
 Worm   683 KDCNEFIEYCVVRGF-DRTSAEARGESPEDVS-KAAYSIVRPNLKT------------------E 727

  Fly   642 KRKQALDQHLSFIVDQTEKFSQQLVEG---MNKSVADTPSL--NSSRLTSPKRESDDDFRPESGS 701
            |:::::|...:.:....|.....:...   :|..::.|...  |:....:|:      .||...:
 Worm   728 KQRESIDSRYNTLCRSIENAKMNIKSNGIRINALLSSTLFYFGNAPEKLTPQ------IRPIVET 786

  Fly   702 EDDEETIAKAEED-------------AADVKEEVTALAKESEMDFDDF---------LNDLPPGY 744
            ...||..|.|.|.             :.:.:..|...||.    |:.|         |....||.
 Worm   787 MQTEENDAMASEVFRGAVPLLVMFSWSRNPRPYVKVFAKA----FESFSGCPIRMPKLGASSPGA 847

  Fly   745 L----------------ENRDKLMKEEQSSAIKTETPDDSDDSE--------FEAKEASDDDENT 785
            |                |..|..  ||.|..|..|    |.::|        |.|.:.::
 Worm   848 LEPWTTTIISMRRIWGKETDDGF--EESSGMISAE----SRNAELFLNILCQFNASQLAE----- 901

  Fly   786 ISKQEEAEQEIDHKKEIDELEADN-----------DLSVEQLLAKYKSEQPP------------- 826
            .....:..:::|....:..||..|           |.|.:::.:...||.|.
 Worm   902 FYCHFDLSEDVDLNTFLTRLELHNSLWNRVGSRLSDQSADKIFSLVPSEDPAIRYAFAKAIETFF 966

  Fly   827 --------SPKRRKLAPRDPELDSDDDSTA-------------------------------VDST 852
                    |....:|.....:||:.:...:                               .|..
 Worm   967 KSSCGDTLSKCYNRLVVLSKDLDNVNSRLSAVEVFLRLCMMDTRYLNGWATLLAPVIFPLLADQC 1031

  Fly   853 EESEDAATEDEEDLSTVKTDTDMEEQDEQEDGL-KSLMADADATSGAAGSGSTAGASGNKDDMLN 916
            |...|||.|....|..|.|   :|..|...:|: :.|:|.....|             |..::|.
 Worm  1032 ETVRDAAGEAFRRLIPVIT---LENPDFSIEGMSQELLAKKSEYS-------------NFINVLG 1080

  Fly   917 DAAALAESLQP--KGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLG 979
            ..::|...::.  :|...:|             .|||||..|:.|:..:....|:|||||:||||
 Worm  1081 SPSSLPRVIRADIRGGFDTS-------------MLREYQLEGITWIRFLRTYGLHGILADDMGLG 1132

  Fly   980 KTIQTIALLA-----------HLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQ 1033
            ||:||:..:|           | .|:       |||.|.:::.:|.:|:.::.|          |
 Worm  1133 KTLQTMCSIALSVDRDEMSEFH-RCS-------LIVCPRTLVDHWCLEWNRFFP----------Q 1179

  Fly  1034 KERKLKRVGWTKPNAFHVCITSYKLVVQDQQS---FRRKKWKYLILDEAQNIKNFKSQRWQLLLN 1095
            :....|.:  |:.:...:|:.:|     |:..   ...:.|.|::|||...::|.|.:.|:....
 Worm  1180 RVPASKNL--TRCHGAEICVIAY-----DELKTAYMMDRVWNYIVLDEGHVMRNSKLRAWKFASQ 1237

  Fly  1096 FSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSN-------PMTGMIEGNMEYN 1153
            ...:.||:|:|||:||...:||||..:|||....|.::|:..|..       |...  |.:::..
 Worm  1238 LVGKSRLILSGTPVQNSPADLWSLFAWLMPGYLGSEKQFRSQFLKKIMKCRLPKAN--EADLKAG 1300

  Fly  1154 ETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNL 1218
            ...|::|||::.||::||||.||.|::|:|......|.|:..|:.:|...:.|. |......|
 Worm  1301 SAAISQLHKLVLPFVMRRLKTEVLKELPEKNVQDYECELTEDQKEIYRFVVDRC-TSSQEDVG-- 1362

  Fly  1219 LSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLH 1283
            ||.:..|:.|||:.:|
 Worm  1363 LSSLVTLITLRKLTDH------------------------------------------------- 1378

  Fly  1284 LEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGA 1348
                               .||:.|
 Worm  1379 -------------------TKLVHD---------------------------------------- 1384

  Fly  1349 SPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSV 1413
                                                                             
 Worm  1385 ----------------------------------------------------------------- 1384

  Fly  1414 LSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTT 1478
                            |.||:      |.|.:.|                ||..|:.|
 Worm  1385 ----------------TLAKI------GAPQYIL----------------SKALAAKS------- 1404

  Fly  1479 VTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLA 1543
                                               ||.|
 Worm  1405 -----------------------------------GKME-------------------------- 1408

  Fly  1544 ALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHL 1608
            |||::.:              :|
 Worm  1409 ALKQLLI--------------EC------------------------------------------ 1417

  Fly  1609 LKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHP 1673
                                   .:|
 Worm  1418 -----------------------EIC--------------------------------------- 1420

  Fly  1674 IISEMTTKFPDPRLIQ-YDCGKLQTMDRLLRQLKVNGHRVLIFTQ---MTKML-DVLEAFLNYHG 1733
                   |.||..:.| .|.|          .|..:|||.|||.|   ..|:: |.|::  ...|
 Worm  1421 -------KNPDEEVEQPEDLG----------GLVASGHRALIFCQWKTSAKLVSDALKS--GEFG 1466

  Fly  1734 HI--YLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDA 1796
            .:  :|.||||.....|..::.|||.||.|...||:|..||||:||||||||||.|.||||..|.
 Worm  1467 SVVSHLVLDGSVPAGDRMKMVNRFNEDKTIDVLILTTHVGGVGLNLTGADTVIFLDHDWNPMKDL 1531

  Fly  1797 QAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFT 1861
            ||.||.||:||||:|::|||:::.|:|..::..|..|...:...|...|.:....::..:.::||
 Worm  1532 QAIDRAHRLGQTRNVNVYRLITQGTVEEKVMSLAKFKLNTAQALIGADNTSMMTMETGELMNMFT 1596

  Fly  1862 MEQSEQ------DESSQEKSE 1876
            ::..|.      .|.:.:||:
 Worm  1597 LDGDEAKKKPGGGEPAAKKSK 1617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	8/36 (22%)
		HepA	692..>1235	CDD:440319	153/675 (23%)
		DEXQc_SRCAP	949..1171	CDD:350761	71/242 (29%)
		SF2_C_SNF	1685..1817	CDD:350180	63/138 (46%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	73/187 (39%)
		HEC1	<1858..>2031	CDD:444066	6/25 (24%)
		SP1-4_N	2486..>2819	CDD:425404
btf-1	NP_496802.2	DUF3535	<572..>792	CDD:463447	21/134 (16%)
		HepA	<1102..1577	CDD:440319	186/920 (20%)