Protein Alignment dom and T23H2.3

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_001032980.2
• Gene: T23H2.3 / 172347
• WormBaseID: WBGene00020742
• Length: 1001
• Species: Caenorhabditis elegans
• Alignment Length: 1343
• Identity: 263/1343 - (19%)
• Similarity: 429/1343 - (31%)
• Gaps: 527/1343 - (39%)

  Fly   611 RVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHL--SFIVDQTEKFSQQLVEGMNKS- 672
            |..|||.   .||...|..:.: |.|...|.:.||.|.:.|  ..|..|::   |.|..|.::|
 Worm    94 RSRSFID---NSFEKPVTPITK-KLQESDEPRAKQQLRERLLRKSIKQQSD---QDLTGGSSRSG 151

  Fly   673 --VADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDD 735
              ..:..||.||.|.      :..|.|          |||....|:|:               ||
 Worm   152 WGTGENSSLESSDLI------NSHFSP----------IAKTFRHASDL---------------DD 185

  Fly   736 FLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKK 800
            .:|..||   .||..|...|.||....:||.....   ||.......:||.|:.:        |.
 Worm   186 SMNTSPP---PNRSTLPSVETSSGNSPQTPYPGSP---EASPQPSPPKNTASELQ--------KL 236

  Fly   801 EIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEED 865
            .|.||||:.|..::  |.|:.|..|.:..|.||     ::|        :.|||.|........|
 Worm   237 SIKELEANKDKKLK--LLKFSSNLPDNGARVKL-----QVD--------EITEEIERRIINGVTD 286

  Fly   866 LSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAG----SGSTAGASGNKDDMLNDAAALAESLQ 926
            ...|...|.:....:.::.:..:..|..|.....|    ||........|.:.::|  .|.:.|.
 Worm   287 TMVVDKTTAIPPPPQPKNLIAPIPQDFAAMLDKNGRKVMSGRMTEQKILKVNKISD--RLMQQLA 349

  Fly   927 PKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLV-TMNERKLNGILADEMGLGKTIQTIALLAH 990
            ...:|:.:...:|..|..|...|..:|..||.||| ...:....|||||:||||||:..::|:.|
 Worm   350 DATHTIPAETDLTDTPDGLLVELMPHQKAGLRWLVWREGQPHSGGILADDMGLGKTLSMLSLIVH 414

  Fly   991 LACAK----------------------GNWGPH--LIVVPSSVMLNWEMEFKKWCPG--FKILTY 1029
            ...|:                      |.:..:  ||:.|:|::..||.|..:....  ..:..:
 Worm   415 QKAARRARKESGDNAADKEKRRVAKEEGLYPSNGTLIIAPASLIHQWEAEINRRLESDLLSVFMF 479

  Fly  1030 YGSQKERKLKRVGWTKPNAFHVCITSYKLVV----------------QDQQS------------- 1065
            :|::|:|:::.....:   :.|.||:|.|..                .|.:|
 Worm   480 HGTKKQRQIEPKELAR---YDVVITTYTLAANELMEKKAAGSKKEEDSDDESENEENPRRPAGKN 541

  Fly  1066 ---FRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYV 1127
               ..|..|..:|||||..|||..||..:.:...|:..|..|:|||:.|:|.:|:||:.||...:
 Worm   542 DSPLARVAWSRVILDEAHAIKNRLSQCSKAVCRLSSFSRWCLSGTPIHNNLWDLYSLVRFLRIPL 606

  Fly  1128 FSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRL 1192
            |...:.:.|......|||.:           |::.:.:..:|||.|.:             .|.|
 Worm   607 FGDRKFWAESIMPMKTGMAD-----------RVNLLTKNLMLRRTKDQ-------------QCAL 647

  Fly  1193 SNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTP 1257
            :|                                  :|:.   |:.|.:..|...:|.|
 Worm   648 TN----------------------------------KKIV---NLKEKKIEIHELEMVG------ 669

  Fly  1258 RLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNG 1322
                                                                |.|        ||
 Worm   670 ----------------------------------------------------DEA--------NG 674

  Fly  1323 KYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALK 1387
               :.|.:   |.||::
 Worm   675 ---YAIMM---EAAQKL------------------------------------------------ 685

  Fly  1388 PVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATN 1452
               :..:||.|..
 Worm   686 ---VKQIVTNTDD---------------------------------------------------- 695

  Fly  1453 SGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTE 1517
                                                                 :||......:.:
 Worm   696 -----------------------------------------------------IQKYGQIRRRRQ 707

  Fly  1518 PEEETEAEDPYKV--QELIQMRKEQRLAALKRMAMINRRR------------TDATPIYGEDCRE 1568
            ...:.|..:||.|  :.|......|.::.:..:.|..|:.            .||..|.|.|..:
 Worm   708 RGNDDEFANPYNVGPRNLAGNSNFQNMSCILLLLMRLRQACVHFHITKSGMDLDAFKINGGDDED 772

  Fly  1569 AIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSV 1633
            |                                  .:..|....|:..|||....::
 Worm   773 A----------------------------------DMKELENLMEKTMADLTIADSD-------- 795

  Fly  1634 CAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTM 1698
                             ..|:.::...::..:|            .|:..:|..|  .|...:|:
 Worm   796 -----------------NDEEGVDTNKEEPKQP------------PTRIFEPDFI--SCKMAKTL 829

  Fly  1699 DRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDK-RIF 1762
            : ::|::.....:|:|.:|.|.:|:::|..:...||.|..:.|...|:.||..::.||.:| ...
 Worm   830 E-VVREILEKKEKVVIVSQWTSVLNLVEKHIQAGGHNYTSITGQVLVKDRQERVDSFNQEKGGAQ 893

  Fly  1763 CFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNIL 1827
            ..:||..:||||:||.|.:.:|..|..|||.::.||.||.:|:||.::|.|:||:.:.|||..::
 Worm   894 VMLLSLTAGGVGLNLIGGNHLIMVDLHWNPALEQQACDRIYRMGQKKEVFIHRLIVKGTIEQRVM 958

  Fly  1828 KKANQKRMLSDMAIEGG-----NFTTTYFKSSTIKDLFTMEQS 1865
            ....:|..|:...:||.     |..||    :.|:.||.::.|
 Worm   959 DLQEKKLALAASVLEGTATRKLNKLTT----ADIRMLFGLDGS 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	1/2 (50%)
		HepA	692..>1235	CDD:440319	138/605 (23%)
		DEXQc_SRCAP	949..1171	CDD:350761	71/280 (25%)
		SF2_C_SNF	1685..1817	CDD:350180	45/132 (34%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	56/170 (33%)
		HEC1	<1858..>2031	CDD:444066	3/8 (38%)
		SP1-4_N	2486..>2819	CDD:425404
T23H2.3	NP_001032980.2	PHA03307	27..>233	CDD:223039	50/182 (27%)
		HepA	<359..973	CDD:440319	172/979 (18%)