Protein Alignment dom and xnp-1

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_001020958.1
• Gene: xnp-1 / 172077
• WormBaseID: WBGene00006961
• Length: 1359
• Species: Caenorhabditis elegans
• Alignment Length: 1658
• Identity: 324/1658 - (19%)
• Similarity: 571/1658 - (34%)
• Gaps: 544/1658 - (32%)

  Fly   506 TPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRL-PKLQEPSRPKAHWDYLLEEMVWLAADF 569
            :|..::::...:||.|....:...|..|:...::::: .|.:|.|:.|.......:|    .:|.
 Worm    74 SPRKSSKKSRKRAKSESESDESDEEEDRKKSKSKKKVDQKKKEKSKKKRTTSSSEDE----DSDE 134

  Fly   570 AQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYK 634
            .:|:|.||.:.|          ..|.|:::.:|:::|          .|:||....|.||.|:.:
 Worm   135 EREQKSKKKSKK----------TKKQTSSESSEESEE----------ERKVKKSKKNKEKSVKKR 179

  Fly   635 HQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMN---KSVADTPSLNSSRLTSPKRESDDDFR 696
            .:|..|.              |:.||.|::..:|:.   ||.:::.|.:...:...|::|....:
 Worm   180 AETSEES--------------DEDEKPSKKSKKGLKKKAKSESESESEDEKEVKKSKKKSKKVVK 230

  Fly   697 PESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIK 761
            .||.|||:.....|.|:.    |...|:..:.||.:..|...:    ..|:..|..|::..:..|
 Worm   231 KESESEDEAPEKKKTEKR----KRSKTSSEESSESEKSDEEEE----EKESSPKPKKKKPLAVKK 287

  Fly   762 TETPDDSDDSEFEA-------------KEASDD-DENTISKQEEAEQEIDHK--KEIDELEADND 810
            ..:.::|::|:.|.             .::.|: |:.:.|:..:.|:::..|  |:.:..|:.:|
 Worm   288 LSSDEESEESDVEVLPQKKKRGAVTLISDSEDEKDQKSESEASDVEEKVSKKKAKKQESSESGSD 352

  Fly   811 LSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDD-DSTAVDS--------------TEESEDAAT 860
            .|...:....||::...|:::|   :...:||.. ....:|:              .:|......
 Worm   353 SSEGSITVNRKSKKKEKPEKKK---KGIIMDSSKLQKETIDAERAEKERRKRLEKKQKEFNGIVL 414

  Fly   861 EDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESL 925
            |:.|||:.:.|.|..:.:      |||::.|.|:        ||......|...:::  :|...|
 Worm   415 EEGEDLTEMLTGTSSQRK------LKSVVLDPDS--------STVDEESKKPVEVHN--SLVRIL 463

  Fly   926 QPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAH 990
            :|.                ..|.::.......:.|..::.....||||..||||||:|.|..| |
 Worm   464 KPH----------------QAHGIQFMYDCAFESLDRLDTEGSGGILAHCMGLGKTLQVITFL-H 511

  Fly   991 LACAKGNWGPH----LIVVPSSVMLNWEMEFKKWCP---------GFKILTYYGSQKERKLKRVG 1042
            ........|..    |:|||.:|::||..||:||..         ....|..|.:.::|:.....
 Worm   512 TVLMHEKIGEKCKRVLVVVPKNVIINWFKEFQKWLVDNDEELDTIDVNELDSYKTIEDRRRALKA 576

  Fly  1043 WTKPNAFHVCITSYK----LVVQDQQSFRRKK-------------WKYL--------ILDEAQNI 1082
            |.......|.|..|.    |.|:|....::.|             .|||        :.|||..:
 Worm   577 WHSSKTPSVMIIGYDLFRILTVEDDPKKKKPKNRNRRLEKAKEDFRKYLQNPGPDMVVCDEAHKL 641

  Fly  1083 KNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIE 1147
            ||..|...:.::...|:||:.||||||||:|||...:::|:.|.:..:..||...|.|.:.   .
 Worm   642 KNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIIN---R 703

  Fly  1148 GNMEYNETLITRLHKVIRPFLLRRLKKEVEKQ--------MPKKYEHVITCRLSNRQRYLYEDFM 1204
            |..:....|.....|.....|...|||.|:::        :|.|.|:||..|.:.||..||..|:
 Worm   704 GRTKDASPLEVSFMKRRCHVLYDHLKKCVDRKDYRVLTEAIPPKQEYVINVRQTERQCALYNAFL 768

  Fly  1205 SRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPF 1269
            :                                          .:.|.:..:.||:.|   |..|
 Worm   769 N------------------------------------------DIVGDSGLSKRLLPD---YHMF 788

  Fly  1270 TQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAE 1334
            ::|......|:|            |:.| :...|.:.||.:.
 Worm   789 SRIWTHPYQLVL------------HEQR-MERERVMREDAEE----------------------- 817

  Fly  1335 LAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTS 1399
                 :.:.:..|.......|||        ..||
 Worm   818 -----EADFIDDGDGSESESEGS--------FKSG------------------------------ 839

  Fly  1400 SSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTS 1464
                :.|.:|...|||:.....::.:.|...| ::.||....|..|.
 Worm   840 ----SESDSGKSVVLSSDDEGSSKKKKNGNKP-EIKKTAPQKKRKFL------------------ 881

  Fly  1465 KTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYK 1529
                                                              .::.|:|.:.||  .
 Worm   882 --------------------------------------------------NSDDEDEEDGED--T 894

  Fly  1530 VQELIQ--MRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYAN 1592
            ...::|  :|:.:|||..:    .:.|.||..|.|
 Worm   895 AMAILQDGIRQSKRLAGEE----ADLRDTDTPPEY------------------------------ 925

  Fly  1593 CCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIE 1657
                    .||.....|...|:|
 Worm   926 --------TGWFARLGLVKEEDR------------------------------------------ 940

  Fly  1658 NIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKML 1722
              .|.||..||.||..||.:              |.::             |.::|:|:|..:.|
 Worm   941 --DDFALSNKLILLVEIIKK--------------CEEI-------------GDKLLVFSQSLESL 976

  Fly  1723 DVLEAFLNY--------------------------HGHIYLRLDGSTRVEQRQILMERFNG--DK 1759
            .:::..|.|                          .|..|:.:|||.:..:|..:...||.  :.
 Worm   977 TLIKRMLEYMAGTGQWFADGHEALNAEGEETWSWLEGEDYMTIDGSVQSGKRDAVQTSFNDPLNL 1041

  Fly  1760 RIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEV 1824
            |....::|||:|.:|.|:..|:.||.:|:.|||:.|.|:..|.:|.|||:.|:|||.:::.|:|.
 Worm  1042 RARLMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFGQTKPVYIYRFIAQGTMEE 1106

  Fly  1825 NILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQ-EKSENKDRIVATTTLS 1888
            .|.|:...|...|...::.......|. .:.:.:|:....|..|...: ..:..|||::|.....
 Worm  1107 RIYKRQVTKESTSMRVVDEAQIQRHYL-GNDLTELYQFTPSTFDPDVEISCAPPKDRLLADVIHK 1170

  Fly  1889 DTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATE--DPNAEGG 1951
            :..:.|...|..:|      .|..|||   :.|:....:...|..:....:|:..:  .|...|.
 Worm  1171 NQHAVVDYIEHDTL------FANVEDE---KLTEQEMKDAWTDYEKDKSGMPVRAQYAAPPMPGF 1226

  Fly  1952 PQVELSKADLE--MQNLVKQLSPI----------ERYAMRFVEETGAAWTAEQLR--------AA 1996
            |...:...:::  :||.:.|...:          |...|| :::.|.|.....||        ..
 Worm  1227 PNGMIVGQNVQALLQNRMNQGIRVDQMQHDILFKELQKMR-IKDAGTAVKIVLLRNLLEQILPYI 1290

  Fly  1997 EAELEAQKREWEANRLAAMHKEEELLKQETEAE 2029
            ..|:.....|:..:.:..:|:.:.  |.||.|:
 Worm  1291 PDEMRGGMSEFNTHFIRLVHETDR--KMETPAD 1321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	15/70 (21%)
		HepA	692..>1235	CDD:440319	140/619 (23%)
		DEXQc_SRCAP	949..1171	CDD:350761	71/259 (27%)
		SF2_C_SNF	1685..1817	CDD:350180	41/159 (26%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	63/262 (24%)
		HEC1	<1858..>2031	CDD:444066	37/195 (19%)
		SP1-4_N	2486..>2819	CDD:425404
xnp-1	NP_001020958.1	HepA	<390..1124	CDD:440319	212/1081 (20%)
		DEAD-like_helicase_N	463..720	CDD:475120	73/276 (26%)