DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dom and LOC100145162

DIOPT Version :9

Sequence 1:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster
Sequence 2:	NP_001265364.2	Gene:	LOC100145162 / 100145162	-ID:	-	Length:	2919	Species:	Xenopus tropicalis

Alignment Length:	3333	Identity:	962/3333 - (28%)
Similarity:	1404/3333 - (42%)	Gaps:	845/3333 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LSPAPPAVPDRVTPHSTEISVAPANSTSTTVRAAGSVGAALPATRHHQHIATQVKGIASSSSKQQ 78
            |||..|.||.....||...:|.|.:...:....||||....|:|..|         :.::.|:|.
Frog   207 LSPGTPTVPAHSLLHSNSQAVGPVHQFGSQSSVAGSVNVQSPSTPSH---------LTTNLSQQL 262

  Fly    79 KQLASAQLPVPLSPLPQQQQQTAEATAAAAAPAHSNVSVSSSTIEASVLPPQAKRQRLDDNEDRT 143
            ..:...|:      :.|||||..         .|.               ||..|   ..:.|||
Frog   263 SSIIQGQI------IQQQQQQQL---------LHG---------------PQVSR---TFSFDRT 294

  Fly   144 SAASIVGPAESS--NIVSSLLPASVASSSEVGGLSS----------------------TALQDLN 184
            |:..|.|.:.:|  .|.|:..|.|.:..:.....||                      .|.|:..
Frog   295 SSGMIAGISGNSAFGITSAATPTSPSQVTGPQAFSSLPLTTAPGTTLKKQTKKLEEIPPATQEDA 359

  Fly   185 ALKKRILQQKLQILRNLKERHLENVSEYFYLQN-GGSMMDYPAWRKKTPTPQFISYSNANRIDQL 248
            .|:|..|....|.::.|||.:.|.:.|.|:||: .|:|||:..::||....|  ::...|.:|..
Frog   360 LLRKLCLDHHHQQMQALKETYTEYLIELFFLQHCQGNMMDFLPFKKKRNIYQ--NFLRQNDLDLE 422

  Fly   249 IHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGNISNSTVKTNTQSQVPS 313
            :.|::...::      :|....|..|...||::.         ||.|..|.
Frog   423 VDEEETEKNS------SQAVYVQTPDPPASSVIE---------APADMEIQ-------------- 458

  Fly   314 KIGSFTESTPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAVEAEIKIPAVGATPVAIST 378
                  .|.||..:|.|.....|.......|:.|...|..|            |:........:.
Frog   459 ------ASDPAMKQSQSPMVTLGLPLLPPVTARSVMDAGMS------------PSKQTCTSVANK 505

  Fly   379 KLPAAVVQLTQQGHIPGRPLGGRHGMVFGQIPAPPAAVGNPSVPLV-----------------PG 426
            :..||.:.:.|....|..|..       .|:|..|.:....::.|.                 ..
Frog   506 QNDAAKISMLQNAAGPQSPFR-------TQLPTMPVSSVQTAMHLAQQQQLITEAHSQTMVKQSS 563

  Fly   427 GTPLLPCNTSAGS--------TALRRPQGQNNAS-----SGSAAASGG--GGSLT-PTPLYTGNG 475
            |.|.|...::..|        ::|::|....:||     |...|.|.|  ..||| |:|....:.
Frog   564 GQPPLHNQSAQPSQEKMVDHFSSLKQPPVPASASKMGSDSVKTAVSVGLKPTSLTSPSPSIPDSV 628

  Fly   476 PAALGGSGG--LTPGT--PTSGSLLSPALGGGSG--------TPNSAAQE--FSFKAKQEVYVMQ 526
            |.|:..|..  |:||.  ..|.:..||.|.|...        .|..|.||  .....:||.::.|
Frog   629 PPAVAVSPKRILSPGASKAVSPASRSPGLAGPQSQEPQCLAPVPGDAQQEALVPKPVEQESHIHQ 693

  Fly   527 RISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYF 591
            ||:||::||:|:.||||:||||.|.|:|||||||||.|:||||||||.||:..|||..:...::.
Frog   694 RIAELRKEGMWSPRRLPRLQEPCRTKSHWDYLLEEMSWMAADFAQERLWKQACAKKLVRTAARHC 758

  Fly   592 QDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVD 656
            |:|.....||:|..|.:|:|:|...|||::.||||:|::||.|.|.:::||.|:|
Frog   759 QEKQQKDARAKKEDEDRLRRIAWLAAREIQYFWSNIEQVVEIKLQVELQEKMKRA---------- 813

  Fly   657 QTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEE 721
                ||.|  :.::|.|            .||:....:               |..:....||..
Frog   814 ----FSAQ--KKLHKGV------------EPKKLDAQN---------------KVIDIVYQVKIA 845

  Fly   722 VTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTI 786
            |.|..                 ||...
Frog   846 VCACT-----------------YLFTM-------------------------------------- 855

  Fly   787 SKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDS 851
                                    |.|..:|.:.|.:|                       |:..
Frog   856 ------------------------LYVPNVLLRAKKDQ-----------------------AISG 873

  Fly   852 TE-ESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGST-AGASGNKDDM 914
            |. ..|.:..|:.|  :.||.           ||.:..:...:|.....||.:| .||..:..|
Frog   874 TNINPESSRVENNE--NAVKA-----------DGNQKAVISIEALLTIEGSNTTPLGARKHCRD- 924

  Fly   915 LNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLG 979
            :.:.||.||.|.|:|::..|..|.|....||..:|||||.:|::|||...::.||||||||.|||
Frog   925 IAEVAAAAELLLPRGSSRISCLVKTSQLPLLHGTLREYQQVGVEWLVKQYKKNLNGILADETGLG 989

  Fly   980 KTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWT 1044
            |.||.|||.:|||..:|.|||:|||..|..:|.||:|.|:|||..|||.|:|||.|.:.||..|.
Frog   990 KNIQVIALFSHLASNEGVWGPYLIVARSCKILKWELELKRWCPALKILLYFGSQSELRRKRQTWN 1054

  Fly  1045 KPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPL 1109
            :||.|:|||||||...:..::|::.:||||:|||...|||.....|:.:||..::|||||...||
Frog  1055 EPNNFNVCITSYKQFFKSHKAFKKMRWKYLVLDEVHQIKNMTEMHWEAILNLPSQRRLLLRDNPL 1119

  Fly  1110 QNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKK 1174
            .:...|||:::|||:|.:..::.:|      |:... :.:.:|..|:..|||:..:||:|||.|:
Frog  1120 PHTWKELWTMVHFLIPGLSRAYLDF------PVNEN-DQDHDYRHTISIRLHRSTQPFILRRSKR 1177

  Fly  1175 EVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFE 1239
            :||:|:.||.|||:.|:||||||.||||.|.:..|::.|:.|:.:||::|||||:::|||..:.:
Frog  1178 DVERQLTKKSEHVLKCQLSNRQRALYEDVMMQPGTQDALKGGHFVSVLHVLMQLQRICNHTELVD 1242

  Fly  1240 ARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMT---AYVSHKSRLLAP 1301
            .|...|.:....|.:.|..|:...:..||:..:.|.:||  |:.:|..||   |.|..|.::
Frog  1243 PRLKHSSYAFKAIKYKTASLILRALLRDPWKNVELASLN--LIGMENNMTRFEAQVLPKQKV--- 1302

  Fly  1302 PRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKI-MPMRNL 1365
            .||||::|..:|.|..| |:     .::::.:.|     ...|..|..|    ||..: .|.
Frog  1303 TRKLIQEIYNSPNPPVR-PS-----RVKIKPSRL-----FEPVLYGQKP----EGRTVTFPS--- 1349

  Fly  1366 LPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPT------------------GALS 1412
            .|..|.:.:.:|:::....     |..|.|||.:....|.:|.                  .|.:
Frog  1350 APQTRTVTQTTATVSQQGQ-----VRRSPVTTPAVPQGAKAPATQGHTPPVQVGAPRPQAPAAFA 1409

  Fly  1413 VLSNSKLLGARSQINAPTPAKVAKT---MQDGKPFFYLTPATNSGAAG------ARLTLT---SK 1465
            ..:..:.|....|.|.|:|..|..:   :..|:.......|:..||.|      ..:||.   :|
Frog  1410 TAAPVRQLSQPPQQNIPSPRLVLSSQARLPTGELVKIAQLASTGGAQGRVAQPETPVTLQFQGNK 1474

  Fly  1466 TTASASTTTSRT-------------------------------TVTASTTSGQQLIRDPIVKDLA 1499
            .|.|.|.....|                               |:...||:.....::|:    .
Frog  1475 FTLSQSQLRQLTAGQPLQLHGNVLQIVSAPGQYLRPQGSVVLPTMPQGTTTNTVRSQNPV----G 1535

  Fly  1500 THVKSTVQKQSIANGKTEPEEETEAEDPYKVQELI----QMRKEQRLAALK----RMAMINRRRT 1556
            ..:.|||....:..|:......|.|:...|..:.:    |...|::...:|    |:...|..|.
Frog  1536 APLPSTVSSTGLVAGRNVQTCSTTADSVPKSNQAVVSPAQESAEEKQRVIKERLDRLFFCNELRC 1600

  Fly  1557 DATPIYGEDCREAIQRCM----QATRSLKRSTWQTRGYANCCTAMAHRNGWS--LNHLLKSFEER 1615
            ...||||.|   .:..|.    .|....:.:.|...|..||..:.......|  |.||:.|.:::
Frog  1601 ARAPIYGTD---LLSFCSLNSPGAWPPSQGTVWSWTGSVNCFLSSHSPENSSDLLRHLIPSHDQQ 1662

  Fly  1616 CADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTT 1680
            .|.|:|:..:.:..||.|.|......|.|....:....:|:|:    .||.:||   |::.|:..
Frog  1663 KASLEPLAKSALCVVPPVVAATPVLMVPNPPPAYIHSLKRLEH----GLRDQLA---PVLCELRE 1720

  Fly  1681 K-------FPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLR 1738
            :       |||.:|||.|.|||:.:..|||:|:..|.|||||:||..|||:||.||::|...:||
Frog  1721 RTTPHCLPFPDLKLIQADSGKLEALAVLLRKLRSEGRRVLIFSQMLLMLDILELFLDFHSLTFLR 1785

  Fly  1739 LDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCH 1803
            :|.:...||.|.||:.||.|:|||..:|||....:|.....||||||||||.||.||.:.|..|.
Frog  1786 IDDNANSEQCQDLMKTFNRDQRIFSVLLSTHIPNLGAYQVEADTVIFYDSDLNPVMDGKTQSWCD 1850

  Fly  1804 RIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQD 1868
            .:|:::|:|:|||||..:||..:|:... |.::.::|.:|.:::..:....||::||  |.....
Frog  1851 LVGRSKDIHVYRLVSANSIEEKLLRNGT-KDLIREVAAQGSDYSLAFLTQQTIQELF--EVCSPL 1912

  Fly  1869 ESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAK--AEVAAD 1931
            |.|..|:|.      ...||..||                      ..|....|.||  .|...:
Frog  1913 EDSGVKAEE------FVLLSQEPS----------------------PSDTITAKVAKPFVEALVE 1949

  Fly  1932 LAEFDENI--PIATEDPNAE-------GGPQVELSKAD--LEMQNLVKQLSPIERYAMRFVEETG 1985
            :...:|:|  |:..:.|||.       .|..|.||:..  .|:..|::||:|||:||:.::|...
Frog  1950 IEHINEDITDPVEEDGPNANTGISHAVNGEPVGLSEPSQFQELVELMQQLTPIEKYALHYLELFH 2014

  Fly  1986 AAWTAEQLRAAEAELEAQKREWEANRLAAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNT- 2049
            ...........|.:|.|.||||::..|..: ||.|.::.|.|.||:|||:|:|:.|..:|...|
Frog  2015 IQRAEAHDECTEEKLNAAKREWDSKHLREL-KEREEVQWEAEEEELLTYTREDAYNMDFIYDGTD 2078

  Fly  2050 --MEQMPMWCPPTPPQDNDNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRR 2112
              .|.||:|.||||||| :||||||..:..||:..||.|:.|||||:|||.||.:||....|  |
Frog  2079 GQTELMPVWTPPTPPQD-ENDIYIDSVMCLMYDTNPIVESKLPPVYMRKERKRHKTDPTAAG--R 2140

  Fly  2113 PNKMRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPN----MPIPGL-KPQLPTKPLTE 2172
            ..|||..::.|||||||||..|...::|:|.|.|:.....|..    .|:|.| ||.:.:.| ..
Frog  2141 KKKMRHGESVVPPRSLFDRAVPNPLKVRKEGKEQKKNILLKQQTQFAKPLPTLIKPVMESGP-DN 2204

  Fly  2173 PEAMAEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYE 2237
            |    ||.:.||.|:|..:..|..||.:|.::||..||||||||::||.||:.|||::|||.|||
Frog  2205 P----EWLISEDWALLQTVKQLLELPLNLSVISPAHTPNWDLVSDVVNSCSRIYRSSKQCRSRYE 2265

  Fly  2238 THIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTA 2302
            ..|.|||||       |.:..||             |||:|:|..|...:..:...:||:.:|..
Frog  2266 NVIIPREEG-------KSENTKP-------------LRTSQIYAQDEGMTHSQLFATRFELMKII 2310

  Fly  2303 YLKKAPPPKRQFSA-PSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPP 2366
            ..|::.|.|..... |...||||..||.|.|| |||:|:.|..:|:::|::|.::::.
Frog  2311 AGKRSQPSKPVLGGNPFQKNPKHASVLAESGI-NYDKPLPPTQVASLRADRIAKEKKA------- 2367

  Fly  2367 VGVGVVQQMQQQSQQQQQPAPPPLPQQQQPQQ---------VVQQVQQQQQQQQQQQQQQVVQQQ 2422
                    :.:|::.|||..    |.||||||         .||.||.|.||....|.|.|||||
Frog  2368 --------LVEQARAQQQSG----PSQQQPQQNGQQPAQTATVQPVQSQTQQLAVTQSQVVVQQQ 2420

  Fly  2423 LPTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQP 2487
                         ||    |.:.|:|.||                        |....|:|
Frog  2421 -------------QQ----VTKAPSTNTT------------------------PISSPALL---- 2440

  Fly  2488 QQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTAGQLQQLAQQSAVASGGQSSVSVVLTTPVQTLPS 2552
                           |..:..|:.||:                :|:|..|...||...|    |:
Frog  2441 ---------------TGAIKTTVPGTN----------------IATGTVSGNVVVSGVP----PT 2470

  Fly  2553 VVQPQIGSGAQIVSISSQTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTV-GTVLTTTANQPQQQH 2616
            ..|                 |:|.              ::||    |.| |||..:.|...|...
Frog  2471 TFQ-----------------PINK--------------RLVS----PVVTGTVSASPAATTQMVQ 2500

  Fly  2617 QTTAVT-TLNTTMLRGQRIVSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPT 2680
            |.||.| ||...|      |:.|....::..|...|.::|: .||      :|.|||.|  ||.|
Frog  2501 QRTAATATLPAEM------VTIATSQGVRAVTPVTGGAVVT-TNL------TQVQTQAR--AVVT 2550

  Fly  2681 SPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPSGSAGA 2745
            ...|.||               ||   |.|.::....|.:|::|.:     |.....||...|
Frog  2551 QVTTATT---------------GG---VQPTSKTLTPAQLQIFRSQ-----QANQVHVPQIQA-- 2590

  Fly  2746 TGATANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSVQMHGQARTQFIKQMA 2810
                    ||.|.|    ...|.|:.:::............|.|.:..:.|:  |.:.|..:|:|
Frog  2591 --------QASGQI----KAVTKVSQEQLLKLQKQKLQQVAQTGTLAGTTQV--QVQPQQTQQLA 2641

  Fly  2811 AGKQQLQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQASGALFTTTTGQQQQQQQQQGQLP 2875
                           |.|.:.||.:|                  |..|.|..|..:..|.|||:.
Frog  2642 ---------------TVTASRAGAVL------------------ASTTMTNLQVARLLQAQGQIQ 2673

  Fly  2876 V-AGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSATNPTVQAG-SVNMTLPQLKPGSQIK 2938
            . :||..||      :|.|....:|.    |:.||||   |.|...|| ||::..||...|.|..
Frog  2674 AQSGQTAQV------ALAKPPVVSAV----VSPGGVT---TLPVTVAGISVSINQPQKVAGGQTV 2725

  Fly  2939 VTMPNQMRHLQMQQQLTMPRKISRMTQLVSAS---GQPTATNIITTTGPQQQQQGVTVSGG---G 2997
            |..|     |.|||.|.:.....:..:.:.:.   ||...|....:|..|||:...|...|   .
Frog  2726 VAQP-----LHMQQVLKVKHPTQQQQKALQSQPSLGQQKITTPQVSTASQQQKVTYTTQPGIKTQ 2785

  Fly  2998 TLPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLSNSVTMQQIQQVMRSGQQGTLATTNLVL 3062
            .|.|..||      .||..|...||||             :.:.:|.||::  ||..:||...|:
Frog  2786 FLTTSLSQ------AQKAVGTQQVQAQ-------------IQVAKIPQVVQ--QQAAIATLQQVV 2829

  Fly  3063 GKTSVGRVIPVSVASQANQRQTIQVVSAASAQALAAGNLRTHVAGPSIASTLKVAAPGS-----A 3122
            .            |||..|.||:.:..|.:........::.||....:.....:||..|     .
Frog  2830 S------------ASQQVQPQTVTLTQATAPGQPQVQMIQAHVVQQKLLQQQVIAAAASPQIQAP 2882

  Fly  3123 GGQTTQQTLIAALQHNQR 3140
            .||:|...|::|...||:
Frog  2883 DGQSTVPGLVSADAQNQQ 2900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	38/70 (54%)
		ASF1_hist_chap	<674..831	CDD:304562	14/156 (9%)
		FAM176	<824..>868	CDD:291517	6/44 (14%)
		SNF2_N	952..1238	CDD:278600	137/285 (48%)
		DEXDc	969..1108	CDD:238005	75/138 (54%)
		Helicase_C	1692..1806	CDD:278689	57/113 (50%)
LOC100145162	NP_001265364.2	EP400_N	1..431	CDD:318084	66/267 (25%)
		DNA_pol3_delta2	<508..>688	CDD:331068	41/186 (22%)
		HSA	712..780	CDD:311466	37/67 (55%)
		SNF2_N	962..1241	CDD:306645	137/285 (48%)
		EBV-NA3	<1316..1542	CDD:332796	44/252 (17%)
		SNF2_N	<1738..>1881	CDD:331286	70/143 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	399	1.000	Domainoid score	I734
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1038	1.000	Inparanoid score	I270
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188211at2759
OrthoFinder	1	1.000	-	-		FOG0001654
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.060