Protein Alignment dom and Srcap

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_001291195.1
• Gene: Srcap / 100043597
• MGIID: 2444036
• Length: 3271
• Species: Mus musculus
• Alignment Length: 3715
• Identity: 1036/3715 - (27%)
• Similarity: 1431/3715 - (38%)
• Gaps: 1420/3715 - (38%)

  Fly   415 AVGNPSVPL---------VPGGTPLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPL 470
            :..:|.:|:         :.|..|:.|                  |||.|..:||.|| ::|..:
Mouse     6 STAHPQLPILQTQMVSDGMTGSNPVSP------------------ASSSSPDSSGAGG-ISPQHI 51

  Fly   471 YTGNGPAALGGSGGLTPGT--PTSGSLLSPA---LGGGSGTPNSAAQEFSFKAKQEVYVMQRISE 530
            ..   .::|.|..|...||  |..|..||.|   :..|.....|.| |.:.:||.|..:..||:|
Mouse    52 AQ---DSSLDGPPGPQDGTTVPLEGFSLSHAADLVNRGQKWEKSHA-EIAEQAKHEAEIETRIAE 112

  Fly   531 LQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKA 595
            |::||.|:.:||||:.||.|||.|||||.|||.||:|||||||:||:..|:|..:||.::.:::.
Mouse   113 LRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQR 177

  Fly   596 TAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEK 660
            ...:||.:.::.:|:|:||.:|::|:.|||||||:|::|.|:::|||||:|||.||.|||.||||
Mouse   178 QKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEK 242

  Fly   661 FSQQLVEGMNKSVA-----DTPSLNSSRLTS----PKRESDD---DFRP-ESGSEDDEETIAKAE 712
            :|..|.:.:|:..|     .:|.|.||...|    |....||   ||:| |...|||||||...|
Mouse   243 YSDLLSQSLNQPPASSKAGSSPCLGSSSAASSPPPPVSRLDDEDGDFQPQEEEEEDDEETIEVEE 307

  Fly   713 E----DAADVKEEVTALAKESEMDFDDFLNDLPPGYL-----------------ENRDKLMKEEQ 756
            :    ||...:.|:..|..|.|:..::.|..|||..|                 :..::.::||.
Mouse   308 QQEGNDAETQRREIELLRHEGELPLEELLRSLPPQLLGGPFSPSQTPSHDSDTQDGPEENIEEEP 372

  Fly   757 SSAIKTETPD-------------DSDDSEFEAKE-ASDDDENTISKQEEAEQEIDHKKEIDELEA 807
            |..::...|.             |.||.||.|.| .::|:|:||:.:|:.|.|:||..|:.||..
Mouse   373 SQDLEVHPPSSAVTQCNKQRWHPDEDDEEFTANEDEAEDEEDTIAAEEQLEGEVDHAMELSELAR 437

  Fly   808 DNDLSVEQLLAKY------------------KSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEE 854
            :.:||:|:||.:|                  :.|...:....:|.....|...:|.|:..||.||
Mouse   438 EGELSMEELLQQYAGAYACDASAPASGDSEDEDEVEANSSDGELEETVEEAAQEDSSSQSDSAEE 502

  Fly   855 -------------------SEDAATEDEEDLSTVKTDTDMEEQDEQED-----------GLKSLM 889
                               ||::.:::.||..: ::..|.|:.||.||           |::.|:
Mouse   503 CSEDEEDEHSEEEMSGSSQSEESESDESEDAQS-QSQADEEQDDEGEDDDVDDDDDDGFGVEYLL 566

  Fly   890 A------DADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHS 948
            |      :.|..||....|.|......|:  :.|.||.||||||||.||::|.|.||:|.||:..
Mouse   567 ARDDERSEVDGGSGPPTPGPTTTLGPKKE--ITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQ 629

  Fly   949 LREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNW 1013
            |||||||||||||||.|:|||||||||||||||||||:|||||||.|||||||||:||:||||||
Mouse   630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNW 694

  Fly  1014 EMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDE 1078
            |||.|:|||.||||||||:||||||||.||||||||||||||||||:||.|:||||.|:||||||
Mouse   695 EMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDE 759

  Fly  1079 AQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMT 1143
            |||||||||||||.||||:::||||||||||||.|||||||||||||:||.||||||||||||:|
Mouse   760 AQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLT 824

  Fly  1144 GMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAK 1208
            |||||:.||||.|:.|||||:|||||||:|.:|||||||||||||.||||.|||.||:|||::..
Mouse   825 GMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTT 889

  Fly  1209 TRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQIN 1273
            |:|||.||:.:||||:||||||||||||:|:.||..|||...||.|.|..||....|..|..:|:
Mouse   890 TKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATEVHPLQRID 954

  Fly  1274 LETLNLLLLHLEQTMTAYVSH----KSRLLAPPRKLIEDIDTAPLPAPR--------------CP 1320
            :...:  |:.||..::.|.:.    :.||   ..:::.:|.|||.|.||              .|
Mouse   955 MGRFD--LIGLEGRVSRYEADTFLPRHRL---SHRILLEIATAPDPPPRPKPVKMKVNRMLQPVP 1014

  Fly  1321 NGKYRFHIRVRS---------------AELAQRIKLNAV--------KVGAS-------PAMRLE 1355
            ..:.|..:.|.|               .|::.:..|..|        .|.||       ||.|..
Mouse  1015 KQEGRTVVVVNSPRPPLGPVPVRPPPGPEVSAQPALGPVPPVLPAPLMVSASPAGTPVVPASRPP 1079

  Fly  1356 GSKIM--------PMRNLLPS------------GRVLKRVSASINPVNMA----------LKPVV 1390
            |..::        |:..:|||            ...|....|...||.::          |||:.
Mouse  1080 GPVLLSPLQPNTGPLPQVLPSPVGVMSGTSRPPTPTLSLKPAPPAPVRLSPAPPPGSSSLLKPLT 1144

  Fly  1391 I------NSVVTTTSSSTTASSPT-------------------------------GALSVLS--- 1415
            :      :.|..||:|||.|:..|                               |.|:.|:
Mouse  1145 VPPGYTLSPVAATTTSSTIATVTTTAVPAPNSTPQRLILSPEMQARLPSGEVVSIGQLASLAQRP 1209

  Fly  1416 -----NSK------------LLGAR-------------------------------------SQI 1426
                 .||            |.||:                                     .|.
Mouse  1210 VTSAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALVQA 1274

  Fly  1427 NAPTPAK------------------------------------------VAKTMQDG-KPFFYLT 1448
            .||||..                                          |.:..:|| .|...|.
Mouse  1275 VAPTPGPTPVSVLPSTPSTTPAPTGLSLPLAANQVPPSMVNNTGVVKIVVRQAPRDGLTPVPPLA 1339

  Fly  1449 PATNSGAAGARLTLTSKTTASASTTTSRTTVTAST------------------------------ 1483
            ||....::|....|||:.|.:.|..:|.|..|..|
Mouse  1340 PAPRPSSSGLPAVLTSRPTLTPSRLSSPTLGTTRTPIPTPTLVRPLLKLVHSPSPEVSASAPGAA 1404

  Fly  1484 ----------------------------------------------------------------- 1483
                                                                             
Mouse  1405 PMTISSSLHMPSSLPGPASSPMTIHNSSPLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPLPIP 1469

  Fly  1484 -----------------------------------------------------------TSG--- 1486
                                                                       |||
Mouse  1470 ITAPLPVSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSALALGLATTPALSPPQTSGHSL 1534

  Fly  1487 ----------------------------------------------------------------- 1486
                                                                             
Mouse  1535 LLATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPM 1599

  Fly  1487 ------------------------------------------------------------QQLIR 1491
                                                                        |.|:.
Mouse  1600 AASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVS 1664

  Fly  1492 DPIVKDLA-------------------------TH------------------------VKSTVQ 1507
            .|:...|:                         ||                        |.:..|
Mouse  1665 TPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQ 1729

  Fly  1508 KQSIANG---------------------------------------------------------- 1514
            ..|:|.|
Mouse  1730 TLSLAPGGPVGPTQTLSLAPVPPLPPSSPVGPAPGHTLTLAPAASSASLLVPTSVQTLTLSPAPV 1794

  Fly  1515 --------------------------------------------------KTEPEEET------- 1522
                                                              |.|||..|
Mouse  1795 PVPTLDLSATQTLALAPALTQAPASQASSLVSASGAASLPVTMVNRLPVPKDEPETLTLRSGPPS 1859

  Fly  1523 -------------------EAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCRE 1568
                               ....|:.:..|.:.||:||...|.|:..::.......|:||   .|
Mouse  1860 PLPTATSFSGPRPRRQPPPPPRSPFYLDSLEEKRKQQRSERLDRIFQLSEAHGALAPVYG---TE 1921

  Fly  1569 AIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSF----EERCADLKPVFANFVIY 1629
            .:..|     :|.:......|..:  ...:|...|:.....:..    ::|...|..:...|:..
Mouse  1922 VLDFC-----TLPQPVASPIGPRS--PGPSHPIFWTYTEAARRAVLFPQQRLEQLSEIIERFIFV 1979

  Fly  1630 VPSVCAPRIRRYVQNLSSTH---W--QHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQ 1689
            :|.|.||     ..:|.:.|   |  .|:...:..:...|.|:...||.|:..|.|:|||.||||
Mouse  1980 MPPVEAP-----PPSLHACHPPPWLAPHQAAFQEQLACELWPRARPLHRIVCNMRTQFPDLRLIQ 2039

  Fly  1690 YDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMER 1754
            ||||||||:..||||||..|||||||||||:||||||.||.||||:||||||||||||||.||||
Mouse  2040 YDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMER 2104

  Fly  1755 FNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSE 1819
            ||.|||||||||||||||||:||||||||:||||||||||||||||||||||||||||||||:||
Mouse  2105 FNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISE 2169

  Fly  1820 RTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVAT 1884
            ||:|.||||||||||||.|||||||||||.|||..||::||.|...|...||
Mouse  2170 RTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPPGSS------------- 2221

  Fly  1885 TTLSDTPSTVVETEKQSLRA-----FEHALAAAEDEQDVQATKTAKAEVAADLAEFDEN--IPIA 1942
                  .|:|.|.|::::.:     .|.||..||||:|::|...||||..|:||||:||  .|..
Mouse  2222 ------VSSVPEDEEEAVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAG 2280

  Fly  1943 T-EDPN--AEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQK 2004
            . |:.|  ..|....|:|:|:.|:..||:||:|||||||:|:|.:....:.|:|:.||.::||.:
Mouse  2281 EGEEANRPGPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAAR 2345

  Fly  2005 REWEANRLAAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDI 2069
            ::.:       ..:||:.:...|.||                              .|...|
Mouse  2346 KDLD-------QAKEEVFRLPHEEEE------------------------------GPGAGD--- 2370

  Fly  2070 YIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGS--RRPNKMRREDNYVPPRSLFDRP 2132
                                            ....|..|:  ||..|:|      .|..|..|
Mouse  2371 --------------------------------EMSCGSSGASHRRSKKIR------APERLGTR- 2396

  Fly  2133 TPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCVFEDMAILHVLVNLQGL 2197
                       .|:|.||                        |.||               .||
Mouse  2397 -----------VSERLRG------------------------ARAE---------------TQG- 2410

  Fly  2198 PCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTL 2262
                    ...||    |:...:.|:              |.:.|:      .||.:::..:|..
Mouse  2411 --------ANHTP----VTSSHHTCN--------------TFVPPQ------CSPVRERIPRPVP 2443

  Fly  2263 RTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEV 2327
            |......|                                  ...|||....::||...|..
Mouse  2444 RPRPPPPP----------------------------------PAPPPPPAPPASPSPAPPPP--- 2471

  Fly  2328 LQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQ 2392
                     ..|.||...|                  ||.           |.....|:|.|||.
Mouse  2472 ---------PAPASPAPPA------------------PPA-----------SPPAASPSPAPLPP 2498

  Fly  2393 QQQPQQVVQQVQQQQQQQQQQQQQQVVQQQLP-TVSNVQQTLPVQ--QTVELVQQQPTTTTTVAV 2454
            .......:...              :....:| :..|....|||.  .|..|:|..|:::.....
Mouse  2499 AASVASAITSA--------------LATAPIPISAPNPVTILPVHILPTPPLLQLPPSSSPASTP 2549

  Fly  2455 PAAGGQLQ-----QLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTS 2514
            |:|...|.     |.|...||||:.:|....::.:         .||.               |:
Mouse  2550 PSACTPLPTCTPLQAQTSVLTSSSPAPLDSLSVPI---------SPGV---------------TN 2590

  Fly  2515 SSLTAGQL----QQLAQQSAVASGGQSSVSVVLTTPVQTLPSVVQPQ--IGSGAQIVSISSQTLP 2573
            ..|.:|::    |:||...::...|       :|....:|.|:|.|:  :.....|:..|.:|||
Mouse  2591 LPLDSGEVGLCAQELAPVESLELPG-------MTNSEASLASLVSPKDLLPVAVDILPESEKTLP 2648

  Fly  2574 VNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTLNTTMLRGQRIVSTA 2638
            ...:|  .|.::.:|:|                    ..|||.....|...|||:|.|...::.:
Mouse  2649 CIPAP--SSTLEAESIP--------------------NGQQQEVPGPVEGTNTTLLPGSEELTMS 2691

  Fly  2639 AGNT------------------LQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQ 2685
            ...:                  |:....:|....|.:| :.....|.:.     :.|..|:|:|.
Mouse  2692 LNESNGLELPPSAASAEPLDELLETHRNSGETREVQIP-ISNSEKPQEL-----VRAEVTAPSTS 2750

  Fly  2686 TTQLVTTKGIPVSALQQGGKTTV-IPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPSGSAGATGAT 2749
            ::...:.:| |:.|.....:|:. :.:..|..|...||...:.|:.|                 .
Mouse  2751 SSATSSPEG-PLPARPPRRRTSADVEIRGQGSGRTGQLPGPKVLRKL-----------------P 2797

  Fly  2750 ANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSVQMHGQARTQFIKQMAAGKQ 2814
            ..||    |:::...:......:..|.:.:||.|            ::....|:..|..|:..:.
Mouse  2798 GRLV----TVVEEKELVKRRRHRAPASTLVPGVS------------EVSASPRSPSIHSMSGPES 2846

  Fly  2815 Q--LQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQASGALFTTTTGQQQQQQQQQGQL-PV 2876
            .  ......:|..::.:|......:..|||.|.            |||.|..:..:..:..: |.
Mouse  2847 SPPSSGPCEAAPTSSLSTPTQSTFIACRHNELG------------TTTGGSPENGEGTELAITPP 2899

  Fly  2877 A-----GQPQQVTQHQIASLVKASTAAAASG-----SSVNAG---GV-------TVSATNPTVQA 2921
            |     |:|.:..:         |.|.|..|     ||::.|   ||       ||:...|.::
Mouse  2900 AVKRRRGRPPKKNR---------SPADAGRGVDEVPSSISKGKTNGVDPVPGPETVTVAEPDLR- 2954

  Fly  2922 GSVNMTLPQLKPGSQ------IKVTMPNQMRHLQMQQQ--------LTMPRKISR---------- 2962
                   ||..||.|      :....|..:..::.:::        |.:|..||.
Mouse  2955 -------PQFVPGPQPPGPQPVHRPEPTILSPVEKRRRGRPPKARDLPIPGTISSPGGGNLESRT 3012

  Fly  2963 --------MTQLVSASGQPTA-TNIITT----TGPQQQQQGVTVSGGGTLPTVASQQQQQQHQ-- 3012
                    :|.|::.   ||| ||.:||    |.|.::::       |..|......:..||.
Mouse  3013 QSLPFPAPLTPLLAC---PTAVTNTVTTVTISTSPPKRKR-------GRPPKNPPSPRPSQHPVL 3067

  Fly  3013 --------QKVGGGNSVQAQLLHIQNTKGLSNSVTMQQIQQVMRSGQQGTLATTNL--------- 3060
                    :..|.|  ||.|.|....::|.|             |.:.|:...|.|
Mouse  3068 DPDSSSILESCGLG--VQRQPLGQAESEGSS-------------SDEDGSRPLTRLARLRLEAEG 3117

  Fly  3061 VLGKTSVGRVIPVSV--------ASQANQRQTIQVVSAA---SAQALAAGNL----------RTH 3104
            :.|:.|.|.::...:        :..:....|..|||..   .:..|..|:|          |..
Mouse  3118 MRGRKSEGSMVMAVIQDDLDLADSGPSGLELTPPVVSLTPKFRSTRLRPGSLVPPLETEKMPRKR 3182

  Fly  3105 VAGP----SIASTLKVAAPGSAGGQ-TTQQTLIAALQHNQRQNASPVRLQTTAGGNLLAVVQQQQ 3164
            ...|    .:|...::..|...|.: :.:::.:.|....:..:.:|.|  .|....|:....|..
Mouse  3183 SGAPVGSSGMAKRGRLQPPSPLGPEGSVEESEVEASGDEEEGDGTPRR--RTGPRRLVGTTNQGD 3245

  Fly  3165 QQQHTSIAGP 3174
            |:...|.|.|
Mouse  3246 QRILRSSAPP 3255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	34/70 (49%)
		HepA	692..>1235	CDD:440319	340/635 (54%)
		DEXQc_SRCAP	949..1171	CDD:350761	191/221 (86%)
		SF2_C_SNF	1685..1817	CDD:350180	117/131 (89%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	165/238 (69%)
		HEC1	<1858..>2031	CDD:444066	61/182 (34%)
		SP1-4_N	2486..>2819	CDD:425404	61/359 (17%)
Srcap	NP_001291195.1	YhaN	87..>228	CDD:443752	68/141 (48%)
		HSA	127..193	CDD:462194	31/65 (48%)
		HepA	417..>921	CDD:440319	304/506 (60%)
		DEXQc_SRCAP	630..852	CDD:350761	191/221 (86%)
		PHA03247	<999..1505	CDD:223021	63/505 (12%)
		PHA03247	<1276..1866	CDD:223021	40/589 (7%)
		SF2_C_SNF	2032..2167	CDD:350180	120/134 (90%)
		PspA	2240..>2358	CDD:441447	49/124 (40%)