DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdp1 and Cebpb

DIOPT Version :9

Sequence 1:	NP_729301.1	Gene:	Pdp1 / 45588	FlyBaseID:	FBgn0016694	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_034013.1	Gene:	Cebpb / 12608	MGIID:	88373	Length:	296	Species:	Mus musculus

Alignment Length:	278	Identity:	65/278 - (23%)
Similarity:	102/278 - (36%)	Gaps:	69/278 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 VQHVANAVAAAVIANEHHNHLNSLKARFQPASSGRKSPFLGFICKSNGKSTSNSKEIIC----PD 425
            ::.:|.|...|..|..||:.|:.|.|....|...:|....|::  |.|::.:.:....|    |.
Mouse    67 LEPLAPAADFAAPAPAHHDFLSDLFADDYGAKPSKKPADYGYV--SLGRAGAKAAPPACFPPPPP 129

  Fly   426 DKYKEEGDIWNVEAQTAFLGPNLWDKTLPYDADLKVTQYADLDEFLSENNIPDGLPGTHLGHSSG 490
            ...|.|......:.:.|                                   |..|....|....
Mouse   130 AALKAEPGFEPADCKRA-----------------------------------DDAPAMAAGFPFA 159

  Fly   491 LGHRSDSLGHAAGLSLGLGHITTKRERSPSPSDCISPDTLNPPSPAESTFSFASSGRDFDPRTRA 555
            |   ...||:.|..|...|.::|....||       |.|   ||||::..:.|:          .
Mouse   160 L---RAYLGYQATPSGSSGSLSTSSSSSP-------PGT---PSPADAKAAPAA----------C 201

  Fly   556 FSDEELKPQPMIKKSRKQFVPDELKDDKYWARRRKNNIAAKRSRDARRQKENQIAMRARYLEKEN 620
            |:.....|    .|::.:...|:|.|: |..||.:||||.::|||..:.:..:...:...|..||
Mouse   202 FAGPPAAP----AKAKAKKTVDKLSDE-YKMRRERNNIAVRKSRDKAKMRNLETQHKVLELTAEN 261

  Fly   621 ATLHQEVEQLKQENMDLR 638
            ..|.::||||.:|...||
Mouse   262 ERLQKKVEQLSRELSTLR 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdp1	NP_729301.1	bZIP_HLF	580..639	CDD:269843	22/59 (37%)
Pdp1	NP_729301.1	coiled coil	581..639	CDD:269843	22/58 (38%)
Cebpb	NP_034013.1	Required for Lys-133 sumoylation. /evidence=ECO:0000250\|UniProtKB:P17676	1..22
		Required for MYC transcriptional repression. /evidence=ECO:0000269\|PubMed:16585579	22..104		11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..199		11/37 (30%)
		bZIP_CEBPB	215..285	CDD:269860	24/66 (36%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	226..246		9/19 (47%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	248..255		0/6 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810