DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdp1 and CEBPD

DIOPT Version :9

Sequence 1:	NP_729301.1	Gene:	Pdp1 / 45588	FlyBaseID:	FBgn0016694	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_005186.2	Gene:	CEBPD / 1052	HGNCID:	1835	Length:	269	Species:	Homo sapiens

Alignment Length:	188	Identity:	55/188 - (29%)
Similarity:	85/188 - (45%)	Gaps:	34/188 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 YADLDEFLSENNIPDG------LPGTHLGHSSGLGHRSDSLGHAAGLSLGLGHITTKRERSPSPS 522
            :|||   .:.|:...|      |||   |.:..||.     |.||...|         :|.|...
Human    82 FADL---FNSNHKAGGAGPLELLPG---GPARPLGP-----GPAAPRLL---------KREPDWG 126

  Fly   523 DCISPDTLNP---PSPAESTFSFASSGRDFDPRT----RAFSDEELKPQPMIKKSRKQFVPDELK 580
            |..:|.:|.|   .:.|::..|.|::|:...|.:    |:...:...|.|..:||..:..||. .
Human   127 DGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREKSAGKRGPDR-G 190

  Fly   581 DDKYWARRRKNNIAAKRSRDARRQKENQIAMRARYLEKENATLHQEVEQLKQENMDLR 638
            ..:|..||.:||||.::|||..:::..::..:...|..||..|||.||||.::...||
Human   191 SPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQLTRDLAGLR 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdp1	NP_729301.1	bZIP_HLF	580..639	CDD:269843	22/59 (37%)
Pdp1	NP_729301.1	coiled coil	581..639	CDD:269843	22/58 (38%)
CEBPD	NP_005186.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..133		14/52 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..219		19/68 (28%)
		bZIP_CEBPD	188..252	CDD:269862	23/62 (37%)
		coiled coil	191..249	CDD:269862	22/58 (38%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	195..222		9/26 (35%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	226..254		12/23 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810