DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pdp1 and CEBPB

DIOPT Version :9

Sequence 1:NP_729301.1 Gene:Pdp1 / 45588 FlyBaseID:FBgn0016694 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_005185.2 Gene:CEBPB / 1051 HGNCID:1834 Length:345 Species:Homo sapiens


Alignment Length:259 Identity:70/259 - (27%)
Similarity:103/259 - (39%) Gaps:52/259 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   394 PASSGRKSPFLG--FICKSNGKSTSNSKEIICPDDKYKEEG--DIWNVEAQTAFLGPNLW----- 449
            |||||:...||.  |.....||   |.|       |..|.|  .:..:.|....|.|..:     
Human   108 PASSGQHHDFLSDLFSDDYGGK---NCK-------KPAEYGYVSLGRLGAAKGALHPGCFAPLHP 162

  Fly   450 -DKTLPYDADLKVT---QYADLDEFLSENNIPDGLPGTHLGHSSGLGHRSDS-LGHAAGLSLGLG 509
             ....|..|:||..   :.||     .:.....|.||...|.::|..:...: ||:.|..|...|
Human   163 PPPPPPPPAELKAEPGFEPAD-----CKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSG 222

  Fly   510 HITTKRERSPSPSDCISPDTLNPPSPAESTFSFASSGRDFDPRTRAFSDEELKPQPMIKKSRKQF 574
            .::|....||       |.|   ||||::.          .|.|..::.....|..:..|::|..
Human   223 SLSTSSSSSP-------PGT---PSPADAK----------APPTACYAGAAPAPSQVKSKAKKTV 267

  Fly   575 VPDELKDDKYWARRRKNNIAAKRSRDARRQKENQIAMRARYLEKENATLHQEVEQLKQENMDLR 638
               :...|:|..||.:||||.::|||..:.:..:...:...|..||..|.::||||.:|...||
Human   268 ---DKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLR 328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pdp1NP_729301.1 bZIP_HLF 580..639 CDD:269843 22/59 (37%)
coiled coil 581..639 CDD:269843 22/58 (38%)
CEBPBNP_005185.2 Required for Lys-174 sumoylation 1..24
Required for MYC transcriptional repression. /evidence=ECO:0000250|UniProtKB:P28033 24..135 13/36 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..67
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 79..116 5/7 (71%)
9aaTAD 116..124 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 157..178 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..271 16/75 (21%)
bZIP_CEBPB 264..334 CDD:269860 23/68 (34%)
coiled coil 271..332 CDD:269860 22/58 (38%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 275..295 9/19 (47%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 297..304 0/6 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3119
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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