DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompA and mey

DIOPT Version :9

Sequence 1:	NP_524831.2	Gene:	nompA / 45587	FlyBaseID:	FBgn0016047	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	NP_001287622.1	Gene:	mey / 43715	FlyBaseID:	FBgn0039851	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	769	Identity:	176/769 - (22%)
Similarity:	270/769 - (35%)	Gaps:	188/769 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   634 RLPYRPLPYPGINDNSLPSDLPHTRPYPTDDDAPFRPYGYGGGRYGENRYEGRYP---------P 689
            :||.||...|             .:.:|.::..|..|.|.|.|....|..|...|         .
  Fly    33 KLPKRPAVKP-------------LKTFPRNNATPIPPTGAGSGVATPNGSELPKPLSVEPAEAIA 84

  Fly   690 RFPPSRERDPVGGYTGRDAP--------------DSIFPDRRYRPSSMDSPRYPYLPDSRG---- 736
            ..||....|..|.......|              |.:.|.....||...|......||..|
  Fly    85 ASPPGSIGDSSGASAAAPVPPAAASAAAVAETKADDLDPTPMATPSGSSSVDEDCEPDMIGFELI 149

  Fly   737 -------P-------PG--RYDDIVHSARRPEPDSAKRYPPAPIAPTGSSSKYASTPNRFP--VG 783
                   |       ||  ...|.:.:.:..|..||..|      .||....:.||.::.|  :.
  Fly   150 TGYVLSAPSKQLETLPGTLMLTDCLEACQANESCSAVNY------ETGLCVMFRSTADQLPGSLS 208

  Fly   784 NDRYPIDIYKYGNRPGPNDLGRRPGLERPPPPFYDYDYEERYGDRYGPYDREY--DGPPGRRPPS 846
            ..:||:                          |..|..:..:|.|  |..:.:  |...|.|.|.
  Fly   209 RSQYPV--------------------------FTVYAQKSCFGVR--PCSKAWCIDRVQGYRLPE 245

  Fly   847 GGPYGRY-------------DSPFN----RPYGGNGLDDRPLPLPGLGLSHPPTPYGGGGAGHVG 894
            .....:.             ::.|.    ..|..:||.:.. .:..:.||.........||.:
  Fly   246 RAKASQSVATRRDCIELCLGETEFTCRSANYYAHSGLCELS-DMDRITLSDEANIAAYDGADY-- 307

  Fly   895 VGVGVNSGPPRPPITRCEESDNFKQIAARHKMRRHFVRRALIVPSLIQCERECIESRDFVCRSFN 959
                :.:.....|...||    ||::|.|.......|.:.  |.:|.:|...|: :..|.|.|::
  Fly   308 ----LENNCAEEPSKLCE----FKRVAGRILKTVDSVHQN--VQTLDECRDLCL-TAPFRCHSYD 361

  Fly   960 YRDSAASGYEDRDRDRDRDSPNCELSDRDSREL-DIHDPGTFDASNYDFYERSIGRSDGECMDVT 1023
            |.::.              ...|.||......| |:.:|       |...|.:.......|.:|:
  Fly   362 YNETG--------------ELVCRLSHHSRATLTDLSEP-------YLSIEEAATYEQSACYNVS 405

  Fly  1024 QTCNEEGMEFTIRTPEGFLGRIYTYGFYDRCFFRGNGGTVNVLRLSGPQGYPD--CGTQR--YGD 1084
            ..|....|...|||.:.|.|::|..|....|....|    |.|.......|.|  |..::  ||.
  Fly   406 IDCRSGEMITKIRTSKLFDGKVYAKGAPKSCAVNVN----NSLEFDLKMRYNDLECNVRQSAYGR 466

  Fly  1085 TLTNIVVVQFSDNVQTSRDKRYNLTCIFRGPGEAVVSSGYIGAGSGSPIPIEYLPAENTLSSKVR 1149
            .: |.:|:|..|.:.||.|....::|.:....:.||::..:|. :|.        .|:|||.::.
  Fly   467 YM-NDIVIQHHDMIVTSSDLGLAVSCQYDLTNKTVVNNVDLGV-TGE--------IESTLSEEII 521

  Fly  1150 L---SILYQ-----GRPTTTIA-VGDPLTFRLEAQDGYNHVTDIFATNVVARDPYSGRSIQLIDR 1205
            :   :::.:     |.....|| |||||..|.|..|. |...:||...:||.|......|.|||.
  Fly   522 VDSPNVIMKITARDGSDMKRIAEVGDPLALRFEIVDA-NSPYEIFVRELVAMDGTDSAEITLIDA 585

  Fly  1206 FGCPVDPFVFPELDKLRDG-DTLEARFNAFKIPESNFLVFEATVRSCREGCQPAYCPGPAG---R 1266
            .|||.|.::...:.||.:. ..|.::|:|||.|.|..:.|.|.|..|...|:|..|.....   :
  Fly   586 NGCPTDQYIMSAMQKLANNRKVLLSQFDAFKFPSSELVQFRALVTPCIPRCEPVICDNDENGELK 650

  Fly  1267 QEPSFGRRRRS-LNTTEIPEPEALALEGSSQL-----EASTLDEVTVVNSTTVS 1314
            ...|:|||:|| ||.|:..|   ||::...|.     :|:..:.:.:|.|..::
  Fly   651 SLLSYGRRKRSVLNGTDGVE---LAIKSERQKRDVSHQAAGDENILLVQSIQIT 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompA	NP_524831.2	PAN_AP_HGF	150..231	CDD:238532
		PAN_AP_HGF	244..>303	CDD:238532
		PAN_AP_HGF	349..424	CDD:238532
		PAN_AP_HGF	914..1011	CDD:238532	21/97 (22%)
		ZP	1025..1264	CDD:214579	75/252 (30%)
mey	NP_001287622.1	PAN_1	146..223	CDD:278453	17/108 (16%)
		PAN_AP_HGF	233..311	CDD:238532	12/84 (14%)
		PAN_AP_HGF	319..>380	CDD:238532	18/81 (22%)
		ZP	408..642	CDD:214579	74/248 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910