DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nompA and cutl-28

DIOPT Version :9

Sequence 1:	NP_524831.2	Gene:	nompA / 45587	FlyBaseID:	FBgn0016047	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	NP_499971.2	Gene:	cutl-28 / 176895	WormBaseID:	WBGene00018256	Length:	696	Species:	Caenorhabditis elegans

Alignment Length:	531	Identity:	113/531 - (21%)
Similarity:	191/531 - (35%)	Gaps:	135/531 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   937 VPSLIQCEREC-IESR-DFVCRSFNYRDSAASGYEDRDRDRDRDSPNCELSDRDSR-----ELDI 994
            |.|..:||:.| |.|| ..||||:.|               |..:..|.|....:|     .|:.
Worm   223 VGSFDECEQMCVIRSRISDVCRSYTY---------------DNSTNECNLMWASARMLGRSPLES 272

  Fly   995 HDPGTFDASNYDFYERSIGRSDGECMDVTQTCNEEGMEFTIRTPEGFLGRIYT------------ 1047
            ..|..|.           |..| :|::.:..|.|:.:|....:...|:|::.|
Worm   273 MKPNLFH-----------GDLD-DCVNFSLKCREDNLEVKASSMRMFIGKMMTKKSKKIMCQEDY 325

  Fly  1048 ---YGFYDRCFFRGNGGTVNVLRLSGPQGYPDCGTQRYGDTLTNIVVVQFSDNVQTSRDKRYNLT 1109
               |.|..:..|:..|...|..:.|..:|.              :.|.:.|.::.|.|||...:.
Worm   326 EGNYDFSSKFDFKKCGLDPNKSKDSTYRGM--------------VHVKEGSTSLVTIRDKVLQVN 376

  Fly  1110 CIFRG--PGEAVVSSGYIGAGSG-------SPIPIEYLPAENTLSSKVRLSILYQGRPTT---TI 1162
            |....  |.|....|..:.....       |.:.:...|...| :.|..|.||  |..:|   |:
Worm   377 CRLHKSMPSEEQFLSVQMNVRENNKTNQVMSDVVVVTAPPAQT-NPKFSLKIL--GLDSTEADTV 438

  Fly  1163 AVGDPLTFRLEAQDGYNHVTDIFATNVVARDPYSGRSIQLIDRFGCPVDPFVFPELDKLRDGDTL 1227
            .:||.....|..:   |...|...||:||:|..:||.:::||..||.:...:..|:.|..:...|
Worm   439 HIGDYGWIMLAVK---NSAEDFTVTNLVAKDVQTGRVLRIIDEDGCVLRRDIVKEIRKTDNYVKL 500

  Fly  1228 EARFNAFKIPESNFLVFEATVRSCREGCQPAYCPG--------------PAGRQEPSFGRRRRSL 1278
            :..|:.|:  ....:|:.|.:.:|..||.|. |..              |.....|.....||||
Worm   501 KISFSGFR--RQTEVVYHAMMETCTVGCMPK-CNQDMMLPEEETNVHSLPLSLDLPRHRMVRRSL 562

  Fly  1279 NTTEIPEPEALALEGSSQLEASTLDEVTVVNSTTVSATLGQVPLNETQLGEKTKETEEPEQVREM 1343
                ..||..|.|  :|.:...|..::|::|..:........|.::.:..:..:
Worm   563 ----AGEPRELQL--TSDVYKVTGHKLTLLNPPSPKQFDFPAPKSDFEFNDNGE----------- 610

  Fly  1344 IEVFETREEIEKESYPR-----KLVAPVETVCMTPAEYHGLITAII--LLMILLFSITLVAGLGY 1401
               |...:.|..:..|.     |.....:..||        :|.::  :.|.|:||..|:....|
Worm   611 ---FHEGDVIVVKHSPNLWTSVKHCLIDDVTCM--------LTVVLGAIQMFLMFSCFLIMYCYY 664

  Fly  1402 R--RYWKSISK 1410
            :  |:::.:::
Worm   665 QQWRFYRELNR 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompA	NP_524831.2	PAN_AP_HGF	150..231	CDD:238532
		PAN_AP_HGF	244..>303	CDD:238532
		PAN_AP_HGF	349..424	CDD:238532
		PAN_AP_HGF	914..1011	CDD:238532	20/80 (25%)
		ZP	1025..1264	CDD:214579	61/279 (22%)
cutl-28	NP_499971.2	APPLE	30..103	CDD:128519
		PAN_1	114..192	CDD:278453
		PAN_1	202..292	CDD:278453	23/95 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870