DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ida and AT1G06590

DIOPT Version :9

Sequence 1:	NP_647837.2	Gene:	ida / 45574	FlyBaseID:	FBgn0041147	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_172146.2	Gene:	AT1G06590 / 837170	AraportID:	AT1G06590	Length:	916	Species:	Arabidopsis thaliana

Alignment Length:	942	Identity:	182/942 - (19%)
Similarity:	320/942 - (33%)	Gaps:	278/942 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TAHKITVLILLKQYVINKKNCLDTGISMRTQRRRM-FYML--------VF-----KLIQEQDKSY 96
            |.|||:|.|||:.|..:.:..|....|...|..|: .|:|        :|     |||.:..:..
plant    14 TPHKISVCILLQIYAPSAQMSLPFPFSSVAQHNRLGLYLLSLTKSCDDIFEPKLEKLINQLREVG 78

  Fly    97 NELHSLLT---TGKYKLDTLMLESFEKAMSEF--CAGSIEALFDFSEIQNIDEILNENYGISQFS 156
            .|:.:.||   |.::.    .|.|.:..::.|  ..|.:.:| |...:|:...||:.|      |
plant    79 EEMDAWLTDHLTNRFS----SLASPDDLLNFFNDMRGILGSL-DSGVVQDDQIILDPN------S 132

  Fly   157 MVGVYVRRVGVVLERLSFPEMMDMYKNVCSYYERG------------------------------ 191
            .:|::|||..:....|||..:..::.::..|.:..
plant   133 NLGMFVRRCILAFNLLSFEGVCHLFSSIEDYCKEAHSSFAQFGAPNNNLESLIQYDQMDMENYAM 197

  Fly   192 --------VRAAASG----------SRMAVAGGILH-REETPPPNPITEKPEDPKPKKKVEAVAR 237
                    .:..|||          |.|....|:|| |:||...:           ||..||...
plant   198 DKPTEEIEFQKTASGIVPFHLHTPDSLMKATEGLLHNRKETSRTS-----------KKDTEATPV 251

  Fly   238 IAQERNPLSKWAPKQAKF---------FINKQSELLE-NNERKALPPLELQKKVQEIIHDLPLTT 292
            .....:.|.:....::.|         |:.:|::.:| :....:.....::..:.::....|...
plant   252 ARASTSTLEESLVDESLFLRTNLQIQGFLMEQADAIEIHGSSSSFSSSSIESFLDQLQKLAPELH 316

  Fly   293 TPYFLGYMNQLRVRDYYNALSALHRALDRS----------PVRLMSQEKGYQYFCVNLAVLHATF 347
            ..:||.|:|:|...||:.||..|.|..|.|          |....|....|:...:.|.::|..|
plant   317 RVHFLRYLNKLHSDDYFAALDNLLRYFDYSAGTEGFDLVPPSTGCSMYGRYEIGLLCLGMMHFRF 381

  Fly   348 GHRDEALAALRESIMLAQEHGDKRSL--------------NLANTWYCLLRDELPLSAVQKSV-- 396
            ||.:.||..|.|::.::|:..:...|              .:|:|...|.....|:::...|:
plant   382 GHPNLALEVLTEAVRVSQQLSNDTCLAYTLAAMSNLLSEMGIASTSGVLGSSYSPVTSTASSLSV 446

  Fly   397 ---------QDANEVDGSLLQNYTLALHFAV-KLGTVAGYQPLRLF------------------- 432
                     :.....|...|:....:.|.|: |...:...:||..|
plant   447 QQRVYILLKESLRRADSLKLRRLVASNHLAMAKFELMHVQRPLLSFGPKASMRHKTCPVSVCKEI 511

  Fly   433 --------DLLQHSDNLT---------------------------NRNN-----FADH------- 450
                    |....|..:|                           :|.:     ..||
plant   512 RLGAHLISDFSSESSTMTIDGSLSSAWLKDLQKPWGPPVISPDSGSRKSSTFFQLCDHLVSIPGS 576

  Fly   451 ASEALA----LRSAVWSAYGRHELAALYSQVLLTGRDRFGSGSAGLGSALASFALWLQLQGEPQL 511
            .|:.:.    ||:..|..||...:|.:.:.|..|   .||..|:...:.||..
plant   577 VSQLIGASYLLRATSWELYGSAPMARMNTLVYAT---LFGDSSSSSDAELAYL------------ 626

  Fly   512 SKVLLHHA-----KQRFPRLPSAEG--WMISQCHVVI-------QAGIYQCRWHDALKACDQL-Y 561
             |::.|.|     |..|..|..||.  ..:|:..|::       :..::......|.:.|::| .
plant   627 -KLIQHLALYKGYKDAFAALKVAEEKFLTVSKSKVLLLKLQLLHERALHCGNLKLAQRICNELGG 690

  Fly   562 LIDPSDSLFQRASIYVAKREFFNARRLL--DKLAVQDNIPFLLRMRVQVLLGYCGMANGRFSSET 624
            |...:..:.....:..:.||   ||.||  .:.:...|:       ...|...|...|.:....:
plant   691 LASTAMGVDMELKVEASLRE---ARTLLAAKQYSQAANV-------AHSLFCTCHKFNLQIEKAS 745

  Fly   625 TMLLL-RVSEEMSEAQMDYELAL----------VDLL-----LALQLLLLGMPQKAYQAIKRCMH 673
            .:||| .:.::...|.:....||          :|||     |.|..|.||:   .....||.:.
plant   746 VLLLLAEIHKKSGNAVLGLPYALASISFCQSFNLDLLKASATLTLAELWLGL---GSNHTKRALD 807

  Fly   674 DIH-------INGGLYERAKTDFVFVRCLLAVNQNDAEKRKAQLLKSQVILQRAAQSFKKLSAHA 731
            .:|       .:|||..||:.......|.|:...:........:|.|   |::|:...:.|..|.
plant   808 LLHGAFPMILGHGGLELRARAYIFEANCYLSDPSSSVSTDSDTVLDS---LRQASDELQALEYHE 869

  Fly   732 KVLDVYVFLAQRFNEFGDRNLRNKYAGEFRRY 763
            ...:....:|..:::.|..:.|.:.|..|:::
plant   870 LAAEASYLMAMVYDKLGRLDEREEAASLFKKH 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ida	NP_647837.2	Apc5_N	48..191	CDD:293878	41/161 (25%)
		TPR repeat	289..323	CDD:276806	14/43 (33%)
		ANAPC5	295..386	CDD:289621	30/114 (26%)
		TPR repeat	333..366	CDD:276806	10/32 (31%)
AT1G06590	NP_172146.2	Apc5_N	15..167	CDD:293878	41/162 (25%)
		TPR repeat	313..347	CDD:276806	13/33 (39%)
		ANAPC5	319..420	CDD:303457	27/100 (27%)
		TPR repeat	367..400	CDD:276806	10/32 (31%)
		Lyase_I_like	<669..>733	CDD:294018	12/73 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4322
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41118
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240631at2759
OrthoFinder	1	1.000	-	-		FOG0006522
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104954
Panther	1	1.100	-	-	LDO	PTHR12830
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.910