DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ida and anapc5

DIOPT Version :9

Sequence 1:	NP_647837.2	Gene:	ida / 45574	FlyBaseID:	FBgn0041147	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_955916.2	Gene:	anapc5 / 322854	ZFINID:	ZDB-GENE-030131-1574	Length:	761	Species:	Danio rerio

Alignment Length:	772	Identity:	188/772 - (24%)
Similarity:	346/772 - (44%)	Gaps:	98/772 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TAHKITVLILLKQYVINKKNCLDTGISMRTQRRRMFYMLVFKLIQEQDKSYNELHSLLTTGKYKL 110
            |.:||.||.||.:        :.|...|....||....|:..|.|..|
Zfish    31 TPYKIAVLALLYE--------MSTTKPMALLDRRRLNKLILPLQQGPD----------------- 70

  Fly   111 DTLMLESFEKAMSEFCAGSIEA------LFDFSEIQNIDE---ILNENYGISQ---FSMVGVYVR 163
              |.||.|.|.:.|.|...:.|      |....|:|:::.   ||...:..|:   .|:||:::|
Zfish    71 --LTLEQFLKIVEECCLRMVNAVKLRLFLMADGELQDMEHFFTILPSAFSDSEPFKTSVVGLFMR 133

  Fly   164 RVGVVLERLSFPEMMDMYKNVCSYYERGVRAAASGSRMAVAGGILHREETPPPNPITEKPEDPKP 228
            ::.:...:|||.::..:||::..:..||.:...|.  :......|...|.|..:.| :|.|...|
Zfish   134 QMLLAYNKLSFSQVYKLYKSLQQFCHRGNQPELSA--LPAEDMELTSNEDPSADHI-DKDELDTP 195

  Fly   229 KKKVEAVARIAQERNPLSKWAPKQAKFFINKQSELLENNERKALPPLELQKKVQEIIHDLPLTTT 293
            ......::|..:.:.|||:   |||::|:.:|:.||:|:|.||:.|.:||.::..|:...|....
Zfish   196 SLHQSELSRSEESQGPLSQ---KQAEYFLARQAYLLKNDENKAMSPAKLQDELNNILKFNPDFAE 257

  Fly   294 PYFLGYMNQLRVRDYYNALSALHRALDRSPVRLMS-------QEKGY----QYFCVNLAVLHATF 347
            .::|.|:|.|||:|.|.:..:|....||   .::|       .::||    :|..:|||.||..|
Zfish   258 AHYLSYLNSLRVQDIYISTHSLLHYFDR---LILSGAEGKSNGDEGYGRSLRYAVLNLATLHCRF 319

  Fly   348 GHRDEALAALRESIMLAQEHGDKRSLNLANTWYCLLR-----DELPLSAVQKSVQDANEVDGSLL 407
            ||..:|..||:|:|.:|||..|...|....:|...|.     |.:.|:      :|:.::.....
Zfish   320 GHYHQADLALQEAIRIAQEANDHVCLQHCLSWLYTLEQMRGSDSVVLT------EDSVKIAAHFC 378

  Fly   408 QNY--TLALHFAVKLGTVAGYQPLRLFDLLQHSDNLTNRNNFADHASEALALRSAVWSAYGRHEL 470
            ..|  :|.:...|:.|...|....:|.|.|:.:|.:..:.:.::....:||..:::|..||:..:
Zfish   379 LPYLASLGIQSLVQQGAKQGMPANKLLDALRGTDIMHWKQSLSELIEISLAQTTSIWRMYGKSTM 443

  Fly   471 AALYSQVLLTGRD----RFG---SGSAGLGSALASFALWLQLQGEPQLSKV---LLHHAKQRF-P 524
            |...:|:||....    .|.   :.:.....||...|   :|..|..|..|   ::.|.||:| |
Zfish   444 AQQQAQLLLNMNSLEPVNFSVQQNNTEAFAVALCHLA---ELHAEQGLYPVVTDIMKHLKQQFPP 505

  Fly   525 RLPSAEGWMISQCHVVIQAGIYQCRWHDALKACDQLYLIDPSDSLFQRASIYVAKREFFNARRLL 589
            ....|:.||:....:..:..:...::|.|......:..::.::.::::|.:..|..:...|.::|
Zfish   506 HTQHAKLWMLCDLKIQFEKAMNDGKYHLAEPHVTAITALNSTEGMYRKAQLLKALNQTTEASKIL 570

  Fly   590 DKLAVQDNIPFLLRMRVQVLLGYCGM---ANGRFSSETTMLL--LRVSEEMSEAQMDYELALVDL 649
            .:|..|.......:|.::|:|....:   ::| |::...:||  |.:|.:.:...:..|..   |
Zfish   571 QQLQQQCEKSKNTQMSIRVMLASAELHWDSSG-FATALPLLLQALALSRQHNLQSLTSETL---L 631

  Fly   650 LLALQLLLLGMPQKAYQAIKRCMHDIHINGGLYERAKTDFVFVRCLLAVNQNDAEKRKAQLLKSQ 714
            .||...|:||:.::|...::..:..:..:|.|.::.:...:..||.:|.....|::.:...::..
Zfish   632 HLAFTQLMLGISEQALGLVQDVLESVLAHGSLMDKGRALLLAARCQMASAGAAAQEHRLSAVELA 696

  Fly   715 V-ILQRAAQSFKKLSAHAKVLDVYVFLAQRFNEFGDRNLRNKYAGEFRRYFTDHPIP 770
            | .|..||..|.:|....::.|:|...|:.....|:.:.||:.|..||  ..|..:|
Zfish   697 VHTLDEAAVYFSRLDCKERMRDIYYLQARLHQTLGNISQRNRCAMLFR--LLDQELP 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ida	NP_647837.2	Apc5_N	48..191	CDD:293878	37/154 (24%)
		TPR repeat	289..323	CDD:276806	12/33 (36%)
		ANAPC5	295..386	CDD:289621	35/106 (33%)
		TPR repeat	333..366	CDD:276806	16/36 (44%)
anapc5	NP_955916.2	Apc5_N	32..161	CDD:293878	37/155 (24%)
		TPR repeat	253..287	CDD:276806	12/36 (33%)
		ANAPC5	259..359	CDD:289621	35/102 (34%)
		TPR repeat	305..338	CDD:276806	15/32 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587076
Domainoid	1	1.000	83	1.000	Domainoid score	I8321
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41118
Inparanoid	1	1.050	180	1.000	Inparanoid score	I3999
OMA	1	1.010	-	-		QHG48739
OrthoDB	1	1.010	-	-		D240631at2759
OrthoFinder	1	1.000	-	-		FOG0006522
OrthoInspector	1	1.000	-	-		oto41552
orthoMCL	1	0.900	-	-		OOG6_104954
Panther	1	1.100	-	-	LDO	PTHR12830
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910