DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ida and such-1

DIOPT Version :9

Sequence 1:	NP_647837.2	Gene:	ida / 45574	FlyBaseID:	FBgn0041147	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_499485.2	Gene:	such-1 / 176583	WormBaseID:	WBGene00013443	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	775	Identity:	140/775 - (18%)
Similarity:	274/775 - (35%)	Gaps:	229/775 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RTQRRRMFYMLVFKLIQEQDKSYNELHSLLTTGKYKLDTLMLESFEKAMSEFCAG--SIEALFDF 136
            :.::.|:|.:|...:|.:.:.||::...::......|...:...|..:|.:...|  .||.||:.
Worm    62 KDEKTRVFTVLYGLIIMKSEISYDDFRCIVRILNDGLGRSIYYRFVTSMEKLAHGEDQIEMLFED 126

  Fly   137 S-----------EIQNIDEILNENYGISQFSMVGVYVRRVGVVLERLSFPEMMDMYKNVCSYYER 190
            :           .::..|..|:|...::..|.:.::::||.:...|.|       ........|:
Worm   127 AFYTAKRPNHEKVLKREDSWLDELTFMNSNSFLYIWIKRVMMQYTRTS-------QNGTFEIAEK 184

  Fly   191 GVRAAASGSRMAVAGGILHREETPPPNPITEKPEDPKPKKKVEAVARIAQERNPLSKWAPKQAKF 255
            ..:...||:...::..||.......|..|.                            ...:|:.
Worm   185 FQKWIISGTLEIISHPILSGINRALPTEID----------------------------CSIRARH 221

  Fly   256 FINKQSELLENNERKALPPLE-------LQKKVQEIIHDLPLTTTPYFLGYMNQLRVRDYYNALS 313
            :...|..|::....||:...:       :.::..::: |:.|.....|      :::::..:|:.
Worm   222 WCAAQLRLVQLCPTKAMSYFQILDWCDTIHRRHHDVV-DVHLLRAAIF------VQLKNSSDAVK 279

  Fly   314 ALHRALDRS-------------PVRLMS-QEKGYQYFCVNLAVLHATFGHRDEALAALRESIMLA 364
            :|.:..|.|             .::||| .:...::..:....:|..||.|..|.|...|||..:
Worm   280 SLKQFFDMSMLEITENSKHALETLKLMSPSQVALRFGPILQGRVHRIFGERQIASALFAESIQQS 344

  Fly   365 QEHGDKRSLNLANTWYCLLRDELPLSAVQ-----------------KSVQDANEVDGSLLQNYTL 412
            |.:.|.....:||.       |:.::::.                 |..:::.|.:..:.||
Worm   345 QVNVDDMCNRIANM-------EVTINSIYMSGPLLQRLSGETFAAGKKEEESVENERRVQQN--- 399

  Fly   413 ALHFAVKLG--TVAGYQ-------PLRLF------DLLQHSDNLTNR----NNFADHASEALALR 458
            ::|.||.|.  |:...|       .|..|      .||...|.:..:    |:.||:.|
Worm   400 SVHAAVDLNVPTLRSLQKNFREDYELHAFLVSMCKFLLCIQDMMDGKFFKHNSTADYVS------ 458

  Fly   459 SAVWSAYGRHELAALYSQVLLTGRDRFGSGSAGLGSALASFALWLQLQGEPQLSKVLLHHAKQRF 523
                  .|.|.|     ::||...::        |..|.:||..:...|  .:...:.|.||:
Worm   459 ------VGFHRL-----RLLLDMNNK--------GFVLQAFANAIMTSG--LIQSGMYHQAKR-- 500

  Fly   524 PRLPSAEGWMISQCHVVIQAGIYQCRWHDALKACDQLY-LIDPSDSLFQRASIYVAKREF----- 582
                .||..::|.|... .:.|.:...| |:...:.:| |....|....:.:|.:.|..|
Worm   501 ----VAETMIVSNCDAP-NSPILETESH-AVAGVNLVYSLAAVGDYEKAQKTIDILKNRFPENIN 559

  Fly   583 ---------------FNARRLLDKLA--------VQDNIPFLLRMRVQVLLGYCGMANGRFSSET 624
                           |....||:|.:        ::.:.|....:|..:||.    |.|:. :|.
Worm   560 WMAARHVDICSKIVNFERNFLLNKYSECSRHLAGLETSAPLEFVLRKSLLLA----ATGKL-AEA 619

  Fly   625 TMLL-----------LRVSEEMS---EAQMDYELALVDL----------------LLALQ---LL 656
            .:||           :|:..:|:   .|...:|.|.:.:                ||.::   .|
Worm   620 VLLLGTYECGDVRGSMRIHMQMATIHTAYGQFETAEIQIQEAGKVAVNAHFLDANLLVVRRVGSL 684

  Fly   657 LLG--MPQKAYQAIKRCMHDIHINGGLYERAKTDFVFVRCLLAVNQN---DAEKRKAQLL 711
            :||  |.::|||.:......|...|...|:|.......|||..::::   ..::.|||::
Worm   685 MLGRFMAREAYQVLHALSAKIEHFGSFIEKAIYHVSMARCLRLMHKDPRVHLKQCKAQII 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ida	NP_647837.2	Apc5_N	48..191	CDD:293878	23/129 (18%)
		TPR repeat	289..323	CDD:276806	6/46 (13%)
		ANAPC5	295..386	CDD:289621	21/104 (20%)
		TPR repeat	333..366	CDD:276806	9/32 (28%)
such-1	NP_499485.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162544
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12830
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R71
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	4.020