DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a17 and CYP709B1

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_566092.1	Gene:	CYP709B1 / 819310	AraportID:	AT2G46960	Length:	519	Species:	Arabidopsis thaliana

Alignment Length:	546	Identity:	139/546 - (25%)
Similarity:	231/546 - (42%)	Gaps:	79/546 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLALIVVIL----------SLLV---FAARRRHGYWQRRGIPHDEVHPLFGN---IKDWPNKR 49
            ::.|||||:||          .:||   |...||   .:.:||........:||   ||....:.
plant     4 VIFLALIVLILIIGLRIFKAFMILVWHPFVLTRR---LKNQGISGPNYRIFYGNLSEIKKMKRES 65

  Fly    50 HIA-------EIFRDYYFKYKNSDYPFAGFFFFFTRT---AVVTDMELLKRVLIKDFNHFENRGV 104
            |::       :||......|:.....:...|.::..|   ..::|.||.|.:|......|.....
plant    66 HLSILDPSSNDIFPRILPHYQKWMSQYGETFLYWNGTEPRICISDPELAKTMLSNKLGFFVKSKA 130

  Fly   105 FYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQ 169
            ....:....|..|..|||..|...|..|.|.|:..::|.|..::|....:|.:.:|.::..:..:
plant   131 RPEAVKLVGSKGLVFIEGADWVRHRRILNPAFSIDRLKIMTTVMVDCTLKMLEEWRKESTKEETE 195

  Fly   170 ----VLEVVDLVARYTADVIGNCAFGLNCNSLYDPKAEF------------VSIGKRAITEHRYG 218
                ..|:.:...|.|||:|...|||    |.|....|.            .|:.:.:|...:|
plant   196 HPKIKKEMNEEFQRLTADIIATSAFG----SSYVEGIEVFRSQMELKRCYTTSLNQVSIPGTQY- 255

  Fly   219 NMLDIFLFGFPKLSRRLRLKLNIQEAEDFYTKIVRETIDYRLRTK-EKRNDFMDSLIEMYKNEQS 282
                     .|..|     .:.:.:.|......::..|..||::| :..:|.:..|::.|..|
plant   256 ---------LPTPS-----NIRVWKLERKMDNSIKRIISSRLQSKSDYGDDLLGILLKAYNTE-- 304

  Fly   283 GNSEDGLTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTY 347
             ..|..::..|::.:...||..|.||:|..:.:....|:.:||.|:||||||....|| .|....
plant   305 -GKERKMSIEEIIHECRTFFFGGHETTSNLLAWTTMLLSLHQDWQEKLREEIFKECGK-EKTPDS 367

  Fly   348 EGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIY-P 411
            |...::|.:..|:||:||.|..::.|.|....:....|.:  |.|||.||||.|.:|.|..:: .
plant   368 ETFSKLKLMNMVIMESLRLYGPVSALAREASVNIKLGDLE--IPKGTTVVIPLLKMHSDKTLWGS 430

  Fly   412 EPEIFKPERFTD--EEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKF-SVSPET 473
            :.:.|.|.||.:  ...|..|:.. |.|..|||.|||..|.|::....|..:::.::| |:..|.
plant   431 DADKFNPMRFANGVSRAANHPNAL-LAFSVGPRACIGQNFVMIEAKTVLTMILQRFRFISLCDEY 494

  Fly   474 QIPMKIVVKNILISAENGIHLKVEKL 499
            :   ...|.|:.|..:.|:.:.::.|
plant   495 K---HTPVDNVTIQPQYGLPVMLQPL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	120/475 (25%)
CYP709B1	NP_566092.1	p450	32..517	CDD:299894	129/516 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810