Protein Alignment Cyp6a17 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 148/583 - (25%)
• Similarity: 264/583 - (45%)
• Gaps: 108/583 - (18%)

  Fly     1 MLLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIK-----DWPNKRHIAEIFRDYYF 60
            |:.:||.|.:|:||.:.:.......::.|:.|.:..|..||:.     .|.::..:.:::.
Human    15 MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYG---- 75

  Fly    61 KYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENR---GVFYNEIDDPLSATLFSIEG 122
                   |..|::.......|:::.:::|:||:::|::|.||   |:.:..:.|   :.|| :..
Human    76 -------PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD---SVLF-LRD 129

  Fly   123 QKWRHLRHKLTPTFTSGKMKNM------------------------------------------- 144
            ::|..:|..|...|:..|:..:
Human   130 KRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLP 194

  Fly   145 FPIVVKVGEEMDKVF-RSKTAADRGQVLEVVDLVARYTADVIGNCAFGLNCNSLYDPKAEFVSIG 208
            |.:|..:.:..|.:. ..|..|:.|...::......||.||:.:.|||...:|...|:..||...
Human   195 FCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHC 259

  Fly   209 KRAITEHRYGNMLDIFLFGFPK----LSRRLRLKLNIQEAEDFYTKIVRETIDYR--LRTKEKRN 267
            || ..|......:.:.|..||.    |:|.|..| |..|...|:.|::|..|..|  ...:|:|.
Human   260 KR-FFEFCIPRPILVLLLSFPSIMVPLARILPNK-NRDELNGFFNKLIRNVIALRDQQAAEERRR 322

  Fly   268 DFMDSLIEMYKNEQSGNSED----------------------------GLTFNELLAQAFIFFVA 304
            ||:..:::...:......:|                            .||.:|::.|||||.:|
Human   323 DFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIA 387

  Fly   305 GFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKE-MKYLEQVVMETLRKYP 368
            |:|..:.|:.||.|.||.|.|.|:||..|: :||.:.:....:..::| :.||:.|:.||||.||
Human   388 GYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYP 451

  Fly   369 VLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCT 433
            .....||....|......:  |..|.::.:....:|:||:.:|.||.|.|||||.|........|
Human   452 PAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFT 514

  Fly   434 WLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKV 496
            :||||.|||:|:|:|.|:::..:.|.:::..::|...||||:|:::..|:.| ..:||:::|:
Human   515 YLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSAL-GPKNGVYIKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	134/508 (26%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	134/520 (26%)