Protein Alignment Cyp6a17 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 165/512 - (32%)
• Similarity: 259/512 - (50%)
• Gaps: 52/512 - (10%)

  Fly     6 LIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKD-----WPNKRHIAEIFRDYYFKYKNS 65
            |:...|.||.......|..:::.|||.....|..|.|..     |...|...|.:.:.:..|:..
Human    14 LVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQ 78

  Fly    66 DYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPL-------SATLFSIEGQ 123
            . |.          .|:.|.:::|.||:|     |...||.|::  ||       ||..|: |.:
Human    79 Q-PM----------LVIMDPDMIKTVLVK-----ECYSVFTNQM--PLGPMGFLKSALSFA-EDE 124

  Fly   124 KWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNC 188
            :|:.:|..|:|.|||.|.|.|.||:.:.|:.:.:..|.:  |:..:.:.:.|....||.|||...
Human   125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQE--AENSKSINLKDFFGAYTMDVITGT 187

  Fly   189 AFGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLF---GFPKLS---RRLRLKLNIQEAEDF 247
            .||:|.:||.:|:..|:...|:.:..    :.||.||.   .||.|:   ..|.:.|..::...|
Human   188 LFGVNLDSLNNPQDPFLKNMKKLLKL----DFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHF 248

  Fly   248 YTKIVRETIDYRLRTKEK-RNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSST 311
            ....:....:.||:.|:| |.||...:|:. :|.:...|...|:..||:||:.|...|.::|:||
Human   249 LKNSIERMKESRLKDKQKHRVDFFQQMIDS-QNSKETKSHKALSDLELVAQSIIIIFAAYDTTST 312

  Fly   312 TMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRM 376
            |:.|.:||||.:.|||.||:|||..|. .:....||:.:.:|:||:.||.||||.:||::.:||:
Human   313 TLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRV 376

  Fly   377 TDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPE-RFTDEEIAARPSCTWLPFGEG 440
            ...|.  |....||.||..|::|...:|:||..:.|||.|.|| ||:.:...:.....::|||.|
Human   377 CKKDI--EINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAG 439

  Fly   441 PRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNI-LISAENGIHLKV 496
            ||||||:||.:....:.:...::.:.|....|||||:|:  .|: ::..|..|.|||
Human   440 PRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKL--DNLPILQPEKPIVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	146/442 (33%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	148/456 (32%)