DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	544	Identity:	133/544 - (24%)
Similarity:	240/544 - (44%)	Gaps:	89/544 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLALIVVILSLL--VFAARRRHGYWQRRGIPHDEVHPLFGNIKDW---------PNKRHIAEI 54
            :|||....::..:|  ::||.|  .|....|.|....       ::|         |.::.:.|:
Mouse    22 LLLLGASWILARILIQIYAAYR--NYRHLHGFPQPPK-------RNWLMGHVGMVTPTEQGLKEL 77

  Fly    55 FRDYYFKYKNSDYPFAGFFFFFTRTAVVT--DMELLKRVL-------IKDFNHFENRGVFYNEID 110
            .|      ....||.....:......|:|  ..::::.:|       :||.       :||:.:.
Mouse    78 TR------LVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDV-------IFYSILK 129

  Fly   111 DPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSK---TAADRGQVLE 172
            ..|...|....|.||...|..|||.|..    |:....||:..:...:..:|   ..:|....|:
Mouse   130 PWLGDGLLVSAGDKWSRHRRMLTPAFHF----NILKPYVKIFNDSTNIMHAKWQRLISDGSARLD 190

  Fly   173 VVDLVARYTADVIGNCAFGLNCNSLYDPKAEFVS--------IGKRAITEHRYGNMLDIFLFGFP 229
            :.:.|:..|.|.:..|.|..:.| ..:..:|:::        :.||    |:...|....|:...
Mouse   191 MFEHVSLMTLDSLQKCVFSFDSN-CQEKSSEYIAAILELSALVAKR----HQQPLMFMDLLYNLT 250

  Fly   230 KLSRRLRLKLNIQEAEDFYTKIVRET--------IDYRLRTKEKRN--DFMDSLIEMYKNEQSGN 284
            ....|.|...|:  ..:|...::||.        :|..|::|.|..  ||:|.|:       ...
Mouse   251 PDGMRFRKACNV--VHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLL-------LSK 306

  Fly   285 SEDG--LTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVF-GKHNKEFT 346
            .|||  |:..::.|:|..|...|.:|:::.:.:.||.|||:.:.|::.|:|:..:. |:..:|..
Mouse   307 DEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIE 371

  Fly   347 YEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYP 411
            ::.:.::.:|...:.|:||.:|.:..::|....|....|.: .|.||.|.:|...|||::|.::|
Mouse   372 WDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR-TIPKGIICLISIFGIHHNPSVWP 435

  Fly   412 EPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIP 476
            :||::.|.||..|.|.......::||..|||||||..|.|.:..|.||..:  .:|.:.|:.:.|
Mouse   436 DPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTL--LRFRLLPDDKEP 498

  Fly   477 MKIVVKNILISAENGIHLKVEKLA 500
            .:  ...:::.||.|:.|:||.|:
Mouse   499 RR--QPELILRAEGGLWLRVEPLS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	116/483 (24%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	119/501 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2076
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930