Protein Alignment Cyp6a17 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 110/532 - (20%)
• Similarity: 184/532 - (34%)
• Gaps: 138/532 - (25%)

  Fly     4 LALIVVILSLLVFAARRRHGYWQRR-----------GIPHDEV-HPLFGNIKDW--------PNK 48
            ||..:|.::||:..:::   .||.|           .||...: .||.|....|        .::
Human    15 LAACLVSVTLLLAVSQQ---LWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSR 76

  Fly    49 RHIAEIFRDYYFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPL 113
            |.          ||.|                 |....||.|.||:.......|.:...|
Human    77 RE----------KYGN-----------------VFKTHLLGRPLIRVTGAENVRKILMGE----- 109

  Fly   114 SATLFSIEGQKW-RHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLV 177
                ..:...:| |..|..|.|...|..:.::.....||   ..|:| |..|.:  ..|..:.||
Human   110 ----HHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKV---FSKIF-SHEALE--SYLPKIQLV 164

  Fly   178 ARYTADVIGNCAFGLN----CNSLYDPKAEFVSIGKRAITEHRYGNMLDIF------LFGFP--- 229
            .:.|.....:....:|    ...|....|..|.:| .:|.|...|::.:::      :|..|
Human   165 IQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLG-FSIPEEDLGHLFEVYQQFVDNVFSLPVDL 228

  Fly   230 -----------------KLSRRLRLKLNIQEAEDFYTKIVRETIDYRLRTKEKRNDFMDSLIEMY 277
                             .|.:.:|.||...:.:|:.                   |.:|.|||..
Human   229 PFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYL-------------------DALDLLIESS 274

  Fly   278 KNEQSGNSEDG--LTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGK 340
            |       |.|  :|..||.........|.:.|:::.....:.:|.::..|.:|||:|:......
Human   275 K-------EHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGIL 332

  Fly   341 HNKEFTYEG------IKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIP 399
            |:.....||      :..::||:.|:.|.:|.:..::...|.....|  |...:.|.||..|:..
Human   333 HSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTF--ELDGFQIPKGWSVMYS 395

  Fly   400 ALGIHYDPDIYPEPEIFKPERFT---DEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYL 461
            ....|....::.:..:|.|:||:   .|:...|  ..:||||.|.|.|:|.....:...|....|
Human   396 IRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGR--FHYLPFGGGVRTCLGKHLAKLFLKVLAVEL 458

  Fly   462 IRGYKFSVSPET 473
            ....:|.::..|
Human   459 ASTSRFELATRT 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	92/450 (20%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	98/484 (20%)