DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	128/544 - (23%)
Similarity:	241/544 - (44%)	Gaps:	89/544 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLALIVVILSLL--VFAARRRHGYWQRRGIPHDEVHPLFGNIKDW---------PNKRHIAEI 54
            :||.....::..:|  ::||.|  .:.:.||.|....       ::|         |.::.:.|:
  Rat    22 LLLFGASWILAQILTQIYAAYR--NFRRLRGFPQPPK-------RNWLMGHVGMVTPTEQGLKEL 77

  Fly    55 FRDYYFKYKNSDYPFAGFFFFFTRTAVVT--DMELLKRVL-------IKDFNHFENRGVFYNEID 110
            .|      ....||.....:......|:|  ..::::.:|       :||.       :||..:.
  Rat    78 TR------LVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDV-------IFYTILK 129

  Fly   111 DPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSK---TAADRGQVLE 172
            ..|...|....|.||...|..|||.|..    |:....||:..:...:..:|   ..::....|:
  Rat   130 PWLGDGLLVSAGDKWSRHRRMLTPAFHF----NILKPYVKIFNDSTNIMHAKWKRLISEGSSRLD 190

  Fly   173 VVDLVARYTADVIGNCAFGLNCNSLYDPKAEFVS--------IGKRAITEHRYGNMLDIFLFGFP 229
            :.:.|:..|.|.:..|.|..:.| ..:..:|:::        :.||    |:...:....|:...
  Rat   191 MFEHVSLMTLDSLQKCVFSFDSN-CQEKSSEYIAAILELSALVAKR----HQQPLLFMDLLYNLT 250

  Fly   230 KLSRRLRLKLNIQEAEDFYTKIVRET--------IDYRLRTKEKRN--DFMDSLIEMYKNEQSGN 284
            ....|.....|:  ..:|...::||.        :|..|::|.|..  ||:|.|: :.|:
  Rat   251 PDGMRFHKACNL--VHEFTDAVIRERRRTLPDQGLDEFLKSKAKSKTLDFIDVLL-LTKD----- 307

  Fly   285 SEDG--LTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVF-GKHNKEFT 346
             |||  |:..::.|:|..|...|.:|:::.:.:.||.||::.:.|::.|:|:..:. .:..:|..
  Rat   308 -EDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDPEEIE 371

  Fly   347 YEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYP 411
            ::.:.::.:|...:.|:||.:|.:..::|....|....|.: .|.||.|.:|...|||::|.::|
  Rat   372 WDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR-TIPKGIICLISIFGIHHNPSVWP 435

  Fly   412 EPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIP 476
            :||::.|.||..|.|.......::||..|||||||..|.|.:..|.||..:  .:|.:.|:.:.|
  Rat   436 DPEVYNPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTL--LRFRLLPDDKEP 498

  Fly   477 MKIVVKNILISAENGIHLKVEKLA 500
            .:  ...:::.||.|:.|:||.|:
  Rat   499 RR--QPELILRAEGGLWLRVEPLS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	112/483 (23%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	113/476 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900