DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	517	Identity:	147/517 - (28%)
Similarity:	263/517 - (50%)	Gaps:	57/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LIVVILSLLVFAARRRHGYWQRR-----GIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNS 65
            |:|::::||..     :|.|..|     |||.....|..|.:..:  .:.:.....:...||..
Zfish    13 LVVLVITLLFI-----YGVWPHRFFIKLGIPGPRPWPFVGTLLSY--AKGLCNFDMECAKKYGK- 69

  Fly    66 DYPFAGFFFFFTRTAVVTDMELLKRVLIKD-FNHFENRGVFYNEIDDPLSATLFSIEGQKWRHLR 129
               ..|.:.......:|.|:|::|.||:|: :::|.||......:..|.|..:..::.::|:.:|
Zfish    70 ---VWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERWKRMR 131

  Fly   130 HKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGLNC 194
            ..|:|.||||::|.:|||.:   ...|:..::....|..|.:::.::||.|:.|||.:.:|.::.
Zfish   132 STLSPYFTSGRLKEIFPIAM---THADRFIKNMQKKDPEQPVKIKEVVAPYSLDVITSSSFSVDI 193

  Fly   195 NSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLS---RRLRLKLNIQEAEDFYTKIVRETI 256
            :|:.:|:..||...|:.|..:.:..:|.:.|. ||.|:   :::.:.|..:.|.||:..::::..
Zfish   194 DSINNPEDPFVINVKKFIQFNMFNPLLLLILL-FPSLAIPLKKMGVTLFSKSAMDFFYSVLKKIK 257

  Fly   257 DYRLRTKEKRNDFMDSLI-------EMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMG 314
            |...:..|.|.||:..::       ::..::.|.....|||.:|:|:|:.:|.:.|:||:|||:.
Zfish   258 DDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFILGGYETTSTTLT 322

  Fly   315 FALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTR---- 375
            |.||.||.|.|..:||.|||...| ..:...||:.:..|.|||..:.|::|..|....|.|
Zfish   323 FLLYNLATNPDCLEKLVEEIDKNF-PLDTPITYDALMRMDYLEMAINESMRLLPTAPRLERSAKK 386

  Fly   376 ------MTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTW 434
                  :|            |.:||:|.||...:.:||||:..|..|:||||:.|..:......:
Zfish   387 TVVINGLT------------IPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAF 439

  Fly   435 LPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKV 496
            :|||.|||||||:|:.:|...:.:..|::.:......|||||:::   |:....:..|.||:
Zfish   440 IPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEM---NVTFQPKVPITLKL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	133/462 (29%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	134/472 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm6472
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.720