DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	516	Identity:	160/516 - (31%)
Similarity:	269/516 - (52%)	Gaps:	39/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSDYPFA 70
            |:..:.:|||......|.|:::.|||..:..|.||.:..:.:..|:.::  |.:.||..    ..
Zfish    10 LLAFLAALLVIYGSWPHRYFKKLGIPGPKAIPFFGTMLRYKDGFHVFDM--DCFEKYGR----IW 68

  Fly    71 GFFFFFTRTAVVTDMELLKRVLIKD-FNHFENRGVFYNEIDDPLSATLFSIEGQKWRHLRHKLTP 134
            |.:........:.|..::|.||||: ::.|.||..|  .::..|...:...|...||.:|..|:|
Zfish    69 GIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNF--RLNGALYDAVSIAEDDDWRRIRSVLSP 131

  Fly   135 TFTSGKMKNMFPIVVK----VGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGLNCN 195
            :||||::|.||.|:.|    :.:.|.|      .|.||:..::.:....|:.||:.:.||.::.:
Zfish   132 SFTSGRLKEMFGIMKKHSHILVDSMGK------TAKRGESADIKEFFGAYSMDVVTSTAFSVDID 190

  Fly   196 SLYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLS---RRLRLKLNIQEAEDFY------TKI 251
            ||.:||..||:..|:.: :....|.|.:.:..||.::   .::...|......||:      .|.
Zfish   191 SLNNPKDPFVTNIKKML-KFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKS 254

  Fly   252 VRETIDYRLRTKEKRNDFMDSLIEM---YKNEQSG-NSEDGLTFNELLAQAFIFFVAGFETSSTT 312
            .|:|........:||.||:..:::.   .|::..| ::|.||:.:|:|:|:.||..||:||||:|
Zfish   255 DRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSMIFIFAGYETSSST 319

  Fly   313 MGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMT 377
            :.|..|.||.|.:...||:|||...| .:.....||.:..|.||:..:.|:||.:||.|.|.|:.
Zfish   320 LSFLFYNLATNPETMKKLQEEIDETF-PNQAPVDYETLMSMDYLDAALSESLRLFPVAARLERVC 383

  Fly   378 DTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPR 442
            ..  :.|.....|.|..:|::|...:|.|||.:.|||.|||||||.....:.....::|||.|||
Zfish   384 KK--TVEINGLLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGLGPR 446

  Fly   443 NCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVE--KLAK 501
            ||||:||..:...:.:..:::.:..||..|||:|:::.. |.|:|.::.|.||::  ||::
Zfish   447 NCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGF-NGLLSPKDPIKLKLQPRKLSQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	143/459 (31%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	149/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm6472
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820