DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	501	Identity:	140/501 - (27%)
Similarity:	257/501 - (51%)	Gaps:	58/501 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSDYPFA 70
            |:.::::||.......||::::.|||.....|.||.                 :..|..
Zfish    13 LVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGT-----------------FLSYTK------ 54

  Fly    71 GFFFFFTRTA-----------------VVTDMELLKRVLIKD-FNHFENRGVFYNEIDDPLSATL 117
            |||.|....|                 :|||:|::|.:::|: ::.|.||.....::..||:..:
Zfish    55 GFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGI 119

  Fly   118 FSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTA 182
            .:::.::|:.:|..|:|.||||::|.:|||.:   ...|:..::....|..|.:::.::||.|:.
Zfish   120 SAVKDERWKRIRGTLSPYFTSGRLKEIFPIAM---THADRFIKNMQKRDHEQPVKIKEVVAPYSL 181

  Fly   183 DVIGNCAFGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLSRRL-RLKLNI--QEA 244
            ||:.:.:|.::.:|:.:|...||:..|..:....:..:: :||..||.::..| ::.:::  :..
Zfish   182 DVVTSSSFSVDIDSINNPDDPFVTNIKNFLKFSLFSPLI-LFLTLFPSIANLLGKMGISVFSRSI 245

  Fly   245 EDFYTKIVRETIDYRLRTKEKRNDFMDSLI------EMYKNEQSGNSEDGLTFNELLAQAFIFFV 303
            .:|:...:|:..|.. :....|.||:..:|      :..|:..|.....|||.:|:|:|:|||.:
Zfish   246 MNFFYTALRKIKDEH-KDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFIL 309

  Fly   304 AGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYP 368
            .|:||:|||:.|.|:.||.|.|..:||.|||...| ..:...:|:.:.:|.|||..:.|::|..|
Zfish   310 GGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNF-PLDTPISYDALMKMDYLEMSINESMRLLP 373

  Fly   369 VLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCT 433
            ....|.|:...  :.|.....|.|.|:|.||...::.||.::..|:.|:||||:.|..:......
Zfish   374 TAPRLERVCKK--TVELNGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQYA 436

  Fly   434 WLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKI 479
            ::|||.|||||||:||.:|...:.:..|::.:......|||||:::
Zfish   437 FMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLEL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	132/468 (28%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	133/476 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm6472
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720