DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	165/510 - (32%)
Similarity:	267/510 - (52%)	Gaps:	22/510 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKD-WPNKRHIAEIFRDYYFKYKNSDYP 68
            ||..:..:|....|...:.:::.|||.:::....|||:.. :..||.:.:|..|.|  .|.....
  Fly     7 ALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLY--TKGGSKK 69

  Fly    69 FAGFFFFFTRTAVVTDMELLKRVLIKDFNHFEN-RGVFYNEIDDP-------LSATLFSIEGQKW 125
            |.|.|.......:|.|.:|:|::.||||:||.| |.||....||.       ..::|||:...:|
  Fly    70 FFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARW 134

  Fly   126 RHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAF 190
            :.:|..|:|.||..||:.||.::.:|.:|.....:...:..:...|::.|...|:|.|||.:.||
  Fly   135 KDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIASTAF 199

  Fly   191 GLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLSRRLRLKLNIQEAEDFYTKIVRET 255
            ||..||..|.:..|..:||:..|.....:|..:..|....|::.|:::|..:::..::.::|.:.
  Fly   200 GLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFFALKGLNKILKVELFDRKSTQYFVRLVLDA 264

  Fly   256 IDYRLRTKEKRNDFMDSL------IEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMG 314
            :.||......|.|.::.|      |:..|.:.|...|  .:..:::||.|:||.||||||:..|.
  Fly   265 MKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVRE--WSDRDIVAQCFVFFFAGFETSAVLMC 327

  Fly   315 FALYELARNQDVQDKLREEIGNV-FGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTD 378
            |..:||..|||||.:|.||:..| .....||.|||.|..||||:|||.|.|||:|....:.|..:
  Fly   328 FTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAVDRECN 392

  Fly   379 TD--FSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGP 441
            .|  |..:..|..:.||.::.:|..|.|.||..:..|..|.||||:||...:....|:.|||.|.
  Fly   393 KDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFPFGLGQ 457

  Fly   442 RNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKV 496
            |||||.||.:::....:.||::.|:|:.:.::.||::::.....:|.:.|..:|:
  Fly   458 RNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	155/459 (34%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	157/477 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461237
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	1	0.950	-	0	Normalized mean entropy	S3417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	12	11.750