DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and CYP4F3

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens

Alignment Length:	480	Identity:	124/480 - (25%)
Similarity:	216/480 - (45%)	Gaps:	74/480 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WPNKRH-IAEIFRDYYFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNE 108
            |....| |..||...|.|      |     ..|...|:|.          ||       .|||:.
Human    91 WVGPWHAIVRIFHPTYIK------P-----VLFAPAAIVP----------KD-------KVFYSF 127

  Fly   109 IDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSK---TAADRGQV 170
            :...|...|....|:||...|..|||.|..    |:....:|:..|...:..:|   .|::....
Human   128 LKPWLGDGLLLSAGEKWSRHRRMLTPAFHF----NILKPYMKIFNESVNIMHAKWQLLASEGSAR 188

  Fly   171 LEVVDLVARYTADVIGNCAFGLNCNSLYDPKAEFVS--IGKRAITEHRYGNML---DIFLFGFPK 230
            |::.:.::..|.|.:..|.|..:.:....| :|:::  :...|:...|:..:|   | ||:....
Human   189 LDMFEHISLMTLDSLQKCVFSFDSHCQEKP-SEYIAAILELSALVTKRHQQILLYID-FLYYLTP 251

  Fly   231 LSRRLRLKLNIQEAEDFYTKIVRET--------ID--YRLRTKEKRNDFMDSLIEMYKNEQSGNS 285
            ..:|.|....:  ..||...:::|.        :|  .:.:.|.|..||:|.|:       ....
Human   252 DGQRFRRACRL--VHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLL-------LSKD 307

  Fly   286 EDG--LTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVF-GKHNKEFTY 347
            |||  |:..::.|:|..|...|.:|:::.:.:.||.||::.:.|::.|:|:..:. .:..||..:
Human   308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEW 372

  Fly   348 EGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPE 412
            :.:.::.:|...:.|:||.:|.:..::|....|....|.: .|.||.|.:|...|.|::|.::|:
Human   373 DDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGR-VIPKGIICLISVFGTHHNPAVWPD 436

  Fly   413 PEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGM--MQTCVGLAYLIRGYKFSVSPETQI 475
            ||::.|.||..:.|..|....::||..|||||||..|.|  |:..:||..|    :|.|.|:...
Human   437 PEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL----RFRVLPDHTE 497

  Fly   476 PMKIVVKNILISAENGIHLKVEKLA 500
            |.:  ...:::.||.|:.|:||.|:
Human   498 PRR--KPELVLRAEGGLWLRVEPLS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	117/456 (26%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	120/473 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2076
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840