DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	530	Identity:	131/530 - (24%)
Similarity:	226/530 - (42%)	Gaps:	77/530 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNS 65
            ::.||.::.::.||:.   ||.|.......|....|.|||::|::....|..|....:...|:
Zfish    19 LIFLACLLTVVKLLIV---RRKGVKTMERFPGPPAHWLFGHVKEFRQDGHDLEKIVKWMELYQ-- 78

  Fly    66 DYPFAGFFFFFTRTAV--VTDMELLKRVLI----KDFNHFENRGVFYNEIDDPLSATLFSIEGQK 124
               ||...:|....||  :.....:|.:|.    ||...::   .|...:.|.|..:    .|||
Zfish    79 ---FAFPLWFGPSLAVLNIHHPSYVKTILTTTEPKDDYAYK---FFIPWLGDGLLVS----TGQK 133

  Fly   125 WRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQV-------LEVVDLVARYTA 182
            |...|..|||.|....:|   |.|..:.:.      :|...|:.:|       .|:...|:..|.
Zfish   134 WFRHRRLLTPGFHYDVLK---PYVKLISDS------TKVMLDKWEVHSRSEESFELFKHVSLMTL 189

  Fly   183 DVIGNCAFGLNCNSLYDP------KAEF-----VSIGKRAITEHRYGNMLDIFLFGFPKLSRRLR 236
            |.|..|||..|.|...|.      :|.|     |::..|....|...      :|.......|.|
Zfish   190 DSIMKCAFSCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKA------IFHLSPHGYRFR 248

  Fly   237 LKLNIQEAEDFYTKIVRETIDYRLRTKEKRN--------DFMDSLIEMYKNEQSGNSEDGLTFNE 293
            ...:|  |.:...:::|:..:. |:.:|::.        ||:|.|:......|.|.|::     :
Zfish   249 KAASI--AHNHTAEVIRKRKEV-LKMEEEQGIVKNRRYLDFLDILLSARDEHQQGLSDE-----D 305

  Fly   294 LLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVF-GKHNKEFTYEGIKEMKYLE 357
            :.|:...|...|.:|:::.:.:..|.||.|.:.|:|.|:||.... ||...|  :|.:.::.|..
Zfish   306 IRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQALDGKATLE--WEDLNKIPYTT 368

  Fly   358 QVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFT 422
            ..:.|:||.:|.:..::|......:..|.: .:.:|..:.:...|||.:..::..|..|.|.||.
Zfish   369 MCIKESLRLHPPVPGISRKLTKPLTFFDGR-TVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFL 432

  Fly   423 DEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILIS 487
            .|.:|.|....::||..|||||||..|.|.:..|.:|..::.|.....|:....|   :..:::.
Zfish   433 PENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAVALTLKRYYLIKDPDHTPKM---IPQVVLR 494

  Fly   488 AENGIHLKVE 497
            :.||||:|::
Zfish   495 SLNGIHIKIK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	117/474 (25%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	122/495 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900