DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp6a23

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	422/500 - (84%)
Similarity:	460/500 - (92%)	Gaps:	0/500 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSD 66
            |||.||.:::|||:|.||||||||||||||||..||::||:||||.|||||.||||||.|||.|.
  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSV 67

  Fly    67 YPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQKWRHLRHK 131
            ||||||:|||||:||:||:||:|||||||||||||||:|||||||||||||||||||||||||||
  Fly    68 YPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKWRHLRHK 132

  Fly   132 LTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGLNCNS 196
            ||||||||||||||||:|||||||:|:|.:||....|||||:|||||||||||||||||||||||
  Fly   133 LTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNS 197

  Fly   197 LYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLSRRLRLKLNIQEAEDFYTKIVRETIDYRLR 261
            |.:|.||||:||||||.|.|||.:||..:|||||||||||||||:|:.|||||.|||.|||||||
  Fly   198 LQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNVQDVEDFYTSIVRNTIDYRLR 262

  Fly   262 TKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDV 326
            |.|||:||||||||||:.||:||:||||:|||:|||||||||||||||||||||||||||.:||:
  Fly   263 TNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDI 327

  Fly   327 QDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIA 391
            ||:||.||.||..|||.||||||||||||||||||||||||||||||||||.|||||||||||||
  Fly   328 QDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIA 392

  Fly   392 KGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCV 456
            |||.||||||||||||:||||||.|||||||||.|||||||||||||||||||||||||:||.||
  Fly   393 KGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACV 457

  Fly   457 GLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVEKLAK 501
            ||||||||||||||.|||||||.|||:||:|||||||||||||:|
  Fly   458 GLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKLSK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	376/441 (85%)
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	389/458 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471797
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	12	11.800