DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a17 and Cyp6g2

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_610744.1	Gene:	Cyp6g2 / 36317	FlyBaseID:	FBgn0033696	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	185/523 - (35%)
Similarity:	285/523 - (54%)	Gaps:	40/523 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHP--LFGNIKDWPNKR-HIAEIFRDYYFKY 62
            ::||.|:..::.:...|.::.:.||:|.|:  .|:.|  :.||:....|.| ..||.....|...
  Fly     3 LVLLILVASLIGIAFLALQQHYSYWRRMGV--REIRPKWIVGNLMGLLNMRMSPAEFISQLYNHP 65

  Fly    63 KNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEID---DPL-SATLFSIEGQ 123
            ...:.||.|...|.....::.|.|:::.:|:|||..|.||   |:..|   ||| |..:|.::..
  Fly    66 DAENEPFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNR---YSSSDPKGDPLGSQNIFFLKNP 127

  Fly   124 KWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAAD---RGQVLEVVDLVARYTADVI 185
            .|:.:|.||:|.||..::|.|||::.:||..:|...|.:...:   |...||..:|.|.||.|||
  Fly   128 AWKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVI 192

  Fly   186 GNCAFGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLD----IFLFGFPKLSRRLRLKLNIQEAED 246
            ...|:|::.||..|||.||...| |::.|.   |:|.    ..:|..|.|...:|.|:...||
  Fly   193 ATVAYGVSANSFTDPKCEFRRHG-RSVFEF---NLLRAAEFTLVFFLPHLVPFVRFKVVPAEA-- 251

  Fly   247 FYTKIVRETIDY----RLRTKEKRNDFMDSLIEMYKNEQ---SGNSEDGLTF--NELLAQAFIFF 302
              |:.:|:||:|    |.::.:||||.:|.|||..::.|   :...:|...|  :.|:|||.:||
  Fly   252 --TRFLRKTINYVMSEREKSGQKRNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFF 314

  Fly   303 VAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKY 367
            .||||:||:||.||:||||::.|||.:|||||.:...:...:.|.:.|:.:::::.:::|.||.|
  Fly   315 TAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLRMY 379

  Fly   368 PVLAHLTRM----TDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAA 428
            |.|..|.|.    .|...:|...|:.:.||..|.||...:|.||..:|:|..|.||||:.|....
  Fly   380 PPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKL 444

  Fly   429 RPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIH 493
            ....|::|||.||..|||.|||.:|..|||..|:|.:..:.|..|...|::..|.|:..|:.|||
  Fly   445 HTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAKGGIH 509

  Fly   494 LKV 496
            |::
  Fly   510 LRL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	168/468 (36%)
Cyp6g2	NP_610744.1	p450	36..511	CDD:278495	175/485 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461105
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900