DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a17 and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	143/536 - (26%)
Similarity:	255/536 - (47%)	Gaps:	70/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPN----KRHIAEIFRDYYFK 61
            ::.|.|:.:::.||.......:.||::||:|..:...|.||   :||    |||......|.|.:
  Fly     3 LITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGN---YPNMFTMKRHAIYDLDDIYRQ 64

  Fly    62 YKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDP----LSATLFSIEG 122
            |||. |...|.|...:...:|.:..|.:||.:.:|.:|.:..:..| ||:.    .:...||:.|
  Fly    65 YKNK-YDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKN-IDEKTDFIFANNPFSLTG 127

  Fly   123 QKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGN 187
            :||:..|..:||..|.|::|.::|:..||.:::.:....:........::...:...:|.:::.:
  Fly   128 EKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTD 192

  Fly   188 CAFGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIF-------LF-----GFPKLSRRLRLKLN 240
            |..||...|..|.....:|            .:.|:|       ||     .||.||..::|:..
  Fly   193 CVLGLGAESFSDKPTPIMS------------KINDLFNQPWTFVLFFILTSSFPSLSHLIKLRFV 245

  Fly   241 IQEAEDFYTKIVRETIDYR-----LRTKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFI 300
            ..:.|.|:..::...::.|     ...:.:|:||:|.::::.:.....|       .:|||.:..
  Fly   246 PVDVERFFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQLGEKRNLDN-------RQLLAYSMT 303

  Fly   301 FFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFT--YEGIKEMKYLEQVVMET 363
            |.:.||||::|.:...|..|.||::.|:.|||||.:    |.::.|  :|.:.::.||:..|.||
  Fly   304 FLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRS----HLQDGTIAFEKLSDLPYLDACVQET 364

  Fly   364 LRKYPVLAHLTRMTDTDF----SPEDPKYFIAKGTIVVIPALGIHY----DPDIYPEPEIFKPER 420
            :|.:|. ..::....|:.    :.|.|.:.:.|||.||:|    ||    |.:.:|.|:.|:|||
  Fly   365 IRLFPP-GFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVP----HYCFMLDEEFFPNPQSFQPER 424

  Fly   421 FTDEEIAA--RPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKN 483
            |.:.:.|.  |....::.||:|||.|||:||..:|....:..||..:...::.:|:.........
  Fly   425 FLEPDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEPGQ 489

  Fly   484 ILISAENGIHLKVEKL 499
            |:.....||.|.:|||
  Fly   490 IITGLRGGIWLDLEKL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	127/478 (27%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	131/499 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460973
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900