DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a17 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	136/516 - (26%)
Similarity:	254/516 - (49%)	Gaps:	40/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKD-WPNKRHIAEIFRDYYFKYKN 64
            :|:|.|:|::...|.:    ...||::|||......|..|:... :..||:||....|.|.|||:
  Fly     9 VLVLTLLVLVYVFLTW----NFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKD 69

  Fly    65 SDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFEN---RGVFYNEIDDPLSATLFSIEGQKWR 126
            :| ...|.|.......:|...|.:.::...||..|.|   |.....:.|..|....|.:.|.:|:
  Fly    70 TD-NMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWK 133

  Fly   127 HLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFG 191
            ..|.::.|..:..::|.::|:...|.::..:..|.:......:.|:.:||...||.:|:.:|..|
  Fly   134 ERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLG 198

  Fly   192 LNCNSLYDPKAEFVSIGKRAI-TEHRYGNMLDIFLFGFPKLSRRLRLKLNI----QEAEDFYTKI 251
            ::..|..|.....:.:.||.. |...:     ||......|.:::|...::    :|.|.|:..|
  Fly   199 VSAQSFTDTPTPLLKMIKRVFNTSFEF-----IFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDI 258

  Fly   252 VRETIDYRL-RTKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMGF 315
            :|..|..|| :.:::|:||::.::::.:.:       ||..:.:|.....|.:.||||::..:..
  Fly   259 IRRCITLRLEKPEQQRDDFLNYMLQLQEKK-------GLHTDNILINTMTFILDGFETTALVLAH 316

  Fly   316 ALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKY-PVLAHLTRMTDT 379
            .:..|.||.:.|||:|:|||:.      :.|::.:.|:.:|:..:.||||.: |.:|....:|:.
  Fly   317 IMLMLGRNPEEQDKVRKEIGSA------DLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEP 375

  Fly   380 -DFSPEDPK-YFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEE----IAARPSCTWLPFG 438
             :|:.::.: ..:..|.:|.||...:|:||..|.:|..||||||.:..    .:.|....:|.||
  Fly   376 FEFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFG 440

  Fly   439 EGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVEKL 499
            :|||:|.|:||.:.|....|..::|.::..|:|:|:...:|.....:.:.:.||:|..:.|
  Fly   441 DGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMATLKGGIYLDFKDL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	121/458 (26%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	120/455 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460961
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900