DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	132/540 - (24%)
Similarity:	227/540 - (42%)	Gaps:	99/540 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLALIVVIL---------SLLVFAARRRHGYWQRRGIPHDEVHPLFGNIK-----DW---PNK 48
            |..|||:..:|         .:|.|...:|..    :.:|...:..|..|:|     :|   ..:
  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFA----KTLPGPTIGELIANVKKGEILNWLKELRE 61

  Fly    49 RHIAEIFRDYYFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPL 113
            :| ..:||.::.|               ....:.||.|.:|::|  ..|....:...|..::..|
  Fly    62 KH-GPVFRIWFGK---------------DLMVMFTDPEDIKQLL--GNNQLLTKSRNYELLEPWL 108

  Fly   114 SATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDK-----VFRSKTAADRGQVLEV 173
            ...|.:..|:.|...|..|||.|       .|.|:.:..|.|::     |.|.:|.|: |:..::
  Fly   109 GKGLLTNGGESWHRRRKLLTPGF-------HFRILSEFKEPMEENCRILVRRLRTKAN-GESFDI 165

  Fly   174 VDLVARYTADVIGNCAFGLNCNSLYDPKAEFV-SIGKRAITEHR----YGNMLDIFLFGFPKLSR 233
            ...:..:..|.|...|.|:..::.....:|:| ::.......|:    :...|::| |...|..:
  Fly   166 YPYITLFALDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVF-FKHTKPGK 229

  Fly   234 -----------------RLRLKLNIQEAEDFYTKIVRETIDYRLRTKEKRNDFMDSLIEMYKNEQ 281
                             |||.:..|||..::..:..::.:.     .::|..|:|.|:   ..:.
  Fly   230 EREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVG-----AKRRLAFLDMLL---LTQM 286

  Fly   282 SGNSEDGLTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFT 346
            .|.:|  |:..::..:...|...|.:|:|:.:.|||..|::|.|||.:..||...:.|:..
  Fly   287 EGGAE--LSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREK---- 345

  Fly   347 YEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYP 411
                :.|.|||.|:.||||.||.:...:|....|.  |..|..:.||..:......:|.||..:|
  Fly   346 ----ESMPYLEAVIKETLRIYPSVPFFSRKVLEDL--EVGKLTVPKGASISCLIYMLHRDPKNFP 404

  Fly   412 EPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIP 476
            :||.|.|:||...|....| ..:..|..|||||||.:|.|::....||.|:|.|:|....:.| |
  Fly   405 DPERFDPDRFLVNEKQMHP-FAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-P 467

  Fly   477 MKIVVKNILISAENGIHLKV 496
            ..:.  .::..:.|||.|::
  Fly   468 KPLA--ELVTKSGNGIRLRI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	119/476 (25%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	120/482 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810