DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	130/538 - (24%)
Similarity:	232/538 - (43%)	Gaps:	76/538 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLLALIVVILSLLVFA----------ARRRHGYWQRRGIPHDEVHPLFG-------NIKDWPNKR 49
            |||.|:.::..||:.|          .||...:.:..|     .|.|.|       |.|...|::
  Rat    27 LLLFLLFLLFRLLLQAFKLFSDFRITCRRLSCFPEPPG-----RHWLLGHMSMYLPNEKGLQNEK 86

  Fly    50 HIAEIFRDYYFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVL-----IKDFNHFENRGVFYNEI 109
            .:.:........:.....|.          .|:...:.:|.||     |...:.|     ||:.:
  Rat    87 KVLDTMHHIILAWVGPFLPL----------LVLVHPDYIKPVLGASAAIAPKDEF-----FYSFL 136

  Fly   110 DDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVV 174
            ...|...|...:|.||...|..|||.|....:|....|..:....|...:|...|.......::.
  Rat   137 KPWLGDGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQSVNIMHAKWRRHLAEGSVTSFDMF 201

  Fly   175 DLVARYTADVIGNCAFGLNCNSLYDPKAEFVS--------IGKRAITEHRYGNMLDIFLFGFPKL 231
            :.|:..|.|.:..|.|..: :...:..::::|        :.:|....|.|   || |::.....
  Rat   202 EHVSLMTLDSLQKCVFSYS-SDCQEKLSDYISSIIELSALVVRRQYRLHHY---LD-FIYYLTAD 261

  Fly   232 SRRLRLKLNIQEAEDFYTKIVRET--------IDYRLRTKE-KRNDFMDSLIEMYKNEQSGNSED 287
            .||.|...:  ...:|.|:::::.        .:..|:.|: |..||:|.|: :.|:|:.....|
  Rat   262 GRRFRQACD--TVHNFTTEVIQQRRRALRELGAEAWLKAKQGKTLDFIDVLL-LAKDEEGKELSD 323

  Fly   288 GLTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVF-GKHNKEFTYEGIK 351
                .::.|:|..|...|.:|:|:.:.:||:.||:..:.|||.||||..|. |:..:|..::.:.
  Rat   324 ----EDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLT 384

  Fly   352 EMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIF 416
            ::.:....:.|:||::|.:..::|....|....|.: .|.||.|.::...|.||:|.::|:.:::
  Rat   385 QLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGR-IIPKGIICLVSIYGTHYNPLVWPDSKVY 448

  Fly   417 KPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVV 481
            .|.||..:....|....::||..|||||||..|.|.:..|.:|..:..::.||....::..|
  Rat   449 NPYRFDPDIPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTRKVRRK--- 510

  Fly   482 KNILISAENGIHLKVEKL 499
            ..:::..|||:.|.||.|
  Rat   511 PELILRTENGLWLNVEPL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	112/471 (24%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	111/471 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900