Protein Alignment Cyp6a17 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_001286433.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 137/544 - (25%)
• Similarity: 240/544 - (44%)
• Gaps: 97/544 - (17%)

  Fly     1 MLLLALIVVILSLLVFAAR-RRHGYWQRRGI---PHDEVHPLFGNIKDWPNKRHIAEIFRDYYFK 61
            :|.:..::::|.||:.||: ..|..|..:.:   |....|.|||:|:::.:.:.:..|      :
Human    18 ILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRI------Q 76

  Fly    62 YKNSDYPFAGFFFFFTRTAVVT--DMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQK 124
            .:...:|.|..::.:.....|.  |.:.:|.:|.:  :..::.| .|..:...:...|..:.||.
Human    77 ERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGR--SDPKSHG-SYKFLAPRIGYGLLLLNGQT 138

  Fly   125 WRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQ--VLEVVDLVARYTADVIGN 187
            |...|..|||.|.:..:|   |.|..:.:.: :|...|.....||  .|||...|:..|.|.|..
Human   139 WFQHRRMLTPAFHNDILK---PYVGLMADSV-RVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMK 199

  Fly   188 CAFG------------------LNCNSLY-----------DPKAEFVSIGK---RAI-TEHRYGN 219
            .||.                  .:.|||.           |......|.|:   ||. ..|::.:
Human   200 SAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTD 264

  Fly   220 MLDIFLFGFPKLSRRLRLKLNIQEAEDFYTKIVRETIDYRLRTKEKRN-DFMDSLIEMYKNEQSG 283
            .:             ::|:....:.|....||           |.||: ||:|.|:       ..
Human   265 QV-------------IQLRKAQLQKEGELEKI-----------KRKRHLDFLDILL-------LA 298

  Fly   284 NSEDG--LTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFT 346
            ..|:|  |:..:|.|:...|...|.:|:::.:.:.||.||.:...|::.||||..:.| .....|
Human   299 KMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLG-DGASIT 362

  Fly   347 YEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYP 411
            :..:.:|.|....:.|.||.||.:..:.|...|..:..|.: .:.||.:|::...|:|::|.::|
Human   363 WNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWP 426

  Fly   412 EPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPE-TQI 475
            ..|:|.|.||...  :|:.|..:|||..|.|||||.:|.|.|..|..|..:  .:|.:.|: |:|
Human   427 NLEVFDPSRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTL--LRFELLPDPTRI 487

  Fly   476 PMKIVVKNILISAENGIHLKVEKL 499
            |  |.:..:::.::|||||::.:|
Human   488 P--IPMARLVLKSKNGIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	121/482 (25%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	127/504 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810