DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a17 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	527	Identity:	139/527 - (26%)
Similarity:	238/527 - (45%)	Gaps:	65/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGN---IKDWPNKRHIAEIFRDYYFKYKN 64
            :..|.:.:|..:....||:......|..|....|...|:   |:| .|...:.||...|...:..
Human    19 VFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQD-DNMEKLEEIIEKYPRAFPF 82

  Fly    65 SDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDP-LSATLFSIEGQKWRHL 128
            ...||..||..:       |.:..|.:|    :..:.:..:..:...| |...|.:::|.||...
Human    83 WIGPFQAFFCIY-------DPDYAKTLL----SRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQH 136

  Fly   129 RHKLTPTFTSGKMKNMFPIVV-KVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFG- 191
            |..|||.|....:|....::. .|...:||  ..|..:.:...:||.:.:...:.|:|..|||.
Human   137 RRLLTPGFHFNILKAYIEVMAHSVKMMLDK--WEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 199

  Fly   192 -LNC--NSLYDPKAEFV-SIGKRAITEHRYGNML---DIFL------FGFPKLSRRLRLKLN--I 241
             .||  ||.:||.|:.: .:.|  |..||..::|   ||..      :.|.||||.|....:  |
Human   200 ETNCQTNSTHDPYAKAIFELSK--IIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTII 262

  Fly   242 QEAEDFYTKIVRETIDYRLRTKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNEL--LAQAFIFFVA 304
            ||.:    |.::..:......|.|..||:|.::       |...|.|.:|:::  .::...|.:|
Human   263 QERK----KSLQAGVKQDNTPKRKYQDFLDIVL-------SAKDESGSSFSDIDVHSEVSTFLLA 316

  Fly   305 GFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPV 369
            |.:|.:.::.:.||.||.|.:.|::.|||:..:.| .....|::.:.||.|....:.||.|..|.
Human   317 GHDTLAASISWILYCLALNPEHQERCREEVRGILG-DGSSITWDQLGEMSYTTMCIKETCRLIPA 380

  Fly   370 LAHLTRMTDTDFSPEDPKYF-----IAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAAR 429
            :..::|    |.|  .|..|     :..|..||:...|:|::|.::..|::|.|.||:.|....|
Human   381 VPSISR----DLS--KPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQR 439

  Fly   430 PSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHL 494
            ....:|||..|.|||||..|.|::..|.:|.::  ..|.|:|:...|:.. ..:.::..:||::|
Human   440 HPYAYLPFSAGSRNCIGQEFAMIELKVTIALIL--LHFRVTPDPTRPLTF-PNHFILKPKNGMYL 501

  Fly   495 KVEKLAK 501
            .::||::
Human   502 HLKKLSE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	128/469 (27%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	131/490 (27%)
CYP4X1	NP_828847.1	heme binding region	447..460		7/12 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810