DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	161/502 - (32%)
Similarity:	265/502 - (52%)	Gaps:	33/502 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSDYPFA 70
            |:...|.|........||.:::.|||..:..||||.|.:          :.|..:|:.:..|...
  Rat    14 LLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTIFN----------YGDGMWKFDDDCYKKY 68

  Fly    71 GFFFFFTR----TAVVTDMELLKRVLIKD-FNHFENRGVFYNEIDDPLSATLFSI---EGQKWRH 127
            |..:.|..    ...:.|.|::|.||:|: ::.|.||..|     .|:.....:|   |.::|:.
  Rat    69 GKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCF-----GPMGFMKKAITMSEDEEWKR 128

  Fly   128 LRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGL 192
            ||..|:|||||||:|.|||::.:.|:.:.|..|.:.|  :|:.:.:.|:...|:.|||...:||:
  Rat   129 LRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEA--KGEPINMKDIFGAYSMDVITGTSFGV 191

  Fly   193 NCNSLYDPKAEFVSIGKRAITEHRYGN-MLDIFLFGF-PKLSRRLRLKLNIQEAEDFYTKIVRET 255
            |.:||.:|:..||...|:.:....:.. :|.:.||.| ..:...|...:..:::.:|:.|.|:..
  Rat   192 NVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTM 256

  Fly   256 IDYRLRTKEK-RNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMGFALYE 319
            ...||.:.:| |.||:..::.. :|.:...|:..|:..|:.|||.||...|::.:||::.|.:||
  Rat   257 KKNRLDSNQKSRVDFLQLMMNT-QNSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYE 320

  Fly   320 LARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPE 384
            ||...:||.||:.||.... .:....||:.:.||:||:.||.|:||.||:...|.|::..|.  |
  Rat   321 LATRPNVQKKLQNEIDRAL-PNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDV--E 382

  Fly   385 DPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRF 449
            ....||.|||:|.||...:|.:|:.:.|||.|.||||:.|...:.....:||||.|||||||:||
  Rat   383 INGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGMRF 447

  Fly   450 GMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKV 496
            .::...:.:..:::.:......:||||:|| .:..:...|..|.||:
  Rat   448 ALISMKLAVIGVLQNFNIQPCEKTQIPLKI-SRQPIFQPEGPIILKL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	147/452 (33%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	143/436 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770