Protein Alignment Cyp6a17 and Cyp17a1

DIOPT Version :10

• Sequence 1: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_036885.2
• Gene: Cyp17a1 / 25146
• RGDID: 2456
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 533
• Identity: 137/533 - (25%)
• Similarity: 222/533 - (41%)
• Gaps: 80/533 - (15%)

  Fly     3 LLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSDY 67
            |:.|:::||:...:...:..|....|.:|.   .||.|::...|.:.|:...|    ||.:....
  Rat     4 LVGLLLLILAYFFWVKSKTPGAKLPRSLPS---LPLVGSLPFLPRRGHMHVNF----FKLQEKYG 61

  Fly    68 PFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRG--VFYNEIDDPLSATLFSIEGQKWRHLRH 130
            |........|.|.::...:|.:.||||....|..|.  |..:.:.|......|:..|..| ||..
  Rat    62 PIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSW-HLHR 125

  Fly   131 KLT-PTFTSGKMKNMFPIVVKVGEEMDKVF--RSKTAADR--GQVLEVVDL---VARYTADVIGN 187
            ||. .||:          :.|.|::::|:.  .:|:..|.  ....|.:||   :.....::|
  Rat   126 KLVFSTFS----------LFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNII-- 178

  Fly   188 CAFGLNCN-SLYDPKAEFVSIGKRAI---TEHRYGNMLDIF--LFGFPKLSRRLRLKLNIQEAED 246
            ||...|.: ...|||...:......|   |..|  |::|||  |..||...         .|...
  Rat   179 CAICFNISYEKKDPKLTAIKTFTEGIVDATGDR--NLVDIFPWLTIFPNKG---------LEVIK 232

  Fly   247 FYTKIVRET---IDYRLRTK---EKRNDFMDSLIEMYKNEQSGNSEDG-----LTFNELLAQAFI 300
            .|.|:..|.   |..:.|.|   :..:...|.||:...|..:.||.:|     .:...:||....
  Rat   233 GYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGD 297

  Fly   301 FFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLR 365
            .|.||.||::|.:.:.|..|..|.:|:.|:::||....| .::..|:.....:..||..:.|.||
  Rat   298 IFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVG-FSRTPTFNDRSHLLMLEATIREVLR 361

  Fly   366 KYPVLAHL-TRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDE--EIA 427
            ..||...| ....:.|.|..:  :.:.|.|.||:....:|:|.:.:.:|:.|.||||.|.  ...
  Rat   362 IRPVAPMLIPHKANVDSSIGE--FTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHL 424

  Fly   428 ARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIP---------------- 476
            ..|:.::||||.|||:|||......:..|..|.|::.:...||.:.|:|
  Rat   425 ITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFK 489

  Fly   477 MKIVVKNILISAE 489
            :||.|:...:.|:
  Rat   490 VKITVRQAWMDAQ 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	122/470 (26%)
Cyp17a1	NP_036885.2	CYP17A1	60..490	CDD:410766	118/456 (26%)