DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	134/534 - (25%)
Similarity:	234/534 - (43%)	Gaps:	82/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFR----DYYFKYK 63
            ::.|:|::|.|.....||:.........|....|.|||         |..||.:    |....:.
  Rat    19 VVILMVIVLKLFSLLLRRQKLARAMDSFPGPPTHWLFG---------HALEIQKLGSLDKVVSWA 74

  Fly    64 NSDYPFAGFFFF--FTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFS------- 119
             ..:|.|...:|  |.....:.:.:..|.|.        :||       ||.:|.::.
  Rat    75 -QQFPHAHPLWFGQFVGFLNIYEPDYAKAVY--------SRG-------DPKAADVYDFFLQWIG 123

  Fly   120 -----IEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEE----MDKVFRSKTAADRGQVLEVVD 175
                 ::|.||...|..|||.|....:|   |.|....|.    :|| :..|  |...:..::..
  Rat   124 KGLLVLDGPKWFQHRKLLTPGFHYDVLK---PYVAIFAESTRMMLDK-WEKK--ASENKSFDIFC 182

  Fly   176 LVARYTADVIGNCAFGL-------NCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLSR 233
            .|.....|.:..|.||.       ..||.|...::...:.::.|...:|.|   .|::......|
  Rat   183 DVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHN---DFIYWLTPHGR 244

  Fly   234 RLRLKLNIQEAEDFYTKIVRE----TIDYRLRTK--EKRN-DFMDSLIEMYKNEQSGNSEDGLTF 291
            |......|  |.|...:::|:    ..|.:.|.|  ::|: ||:|.|:.:  .::||..   |:.
  Rat   245 RFLRACKI--AHDHTDEVIRQRKAALQDEKERKKIQQRRHLDFLDILLGV--RDESGIK---LSD 302

  Fly   292 NELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYL 356
            .||.|:...|...|.:|:::.:.:.||.:|...:.|...|||:..:.|..: .|.::.:.:|.||
  Rat   303 AELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQD-SFQWDDLAKMTYL 366

  Fly   357 EQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERF 421
            ...:.|..|.||.:..:.|..:...:..|.:...| |:::.:....:|.:..::|:||:|.|.||
  Rat   367 TMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPA-GSLISLHIYALHRNSTVWPDPEVFDPLRF 430

  Fly   422 TDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILI 486
            :.|..|.|....::||..|||||||.:|.|.:..|..|..:..::||:.| :::|:|  |..:::
  Rat   431 SPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDP-SKMPIK--VPQLIL 492

  Fly   487 SAENGIHLKVEKLA 500
            .::|||||.::.||
  Rat   493 RSKNGIHLYLKPLA 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	118/477 (25%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	124/498 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900