Protein Alignment Cyp6a17 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 117/528 - (22%)
• Similarity: 198/528 - (37%)
• Gaps: 138/528 - (26%)

  Fly     1 MLLLALIVVILSL-LVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKN 64
            :|.:.||....:| ||:..|...|:          :..|...:|..|           |.|
Human    32 LLSMLLIACAFTLSLVYLIRLAAGH----------LVQLPAGVKSPP-----------YIF---- 71

  Fly    65 SDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQKWRHL- 128
            |..||.|....|.::.:    |.|:       |.:|..|..::          |::.|:.:.:|
Human    72 SPIPFLGHAIAFGKSPI----EFLE-------NAYEKYGPVFS----------FTMVGKTFTYLL 115

  Fly   129 ----------------------RHKLTPTFTSG-----------KMKNMFPIVVKVG-------- 152
                                  ....||.|..|           :.|.|....:.:.
Human   116 GSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI 180

  Fly   153 --EEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGLNCNSLYDPKAEFVSIGKRAITEH 215
              :|..:.|.|...:....|.|.:..:...||   .:|..|....|..:.|           ...
Human   181 IEKETKEYFESWGESGEKNVFEALSELIILTA---SHCLHGKEIRSQLNEK-----------VAQ 231

  Fly   216 RYGNMLDIF------LFGF---PKLSRRLRLKLNIQEAEDFYTKIVRETIDYRLRTKEKRNDFMD 271
            .|.::...|      |.|:   |...||.|..   :|.:|.:.|.:::    |.:::||.:|.:.
Human   232 LYADLDGGFSHAAWLLPGWLPLPSFRRRDRAH---REIKDIFYKAIQK----RRQSQEKIDDILQ 289

  Fly   272 SLIE-MYKNEQSGNSEDG--LTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREE 333
            :|:: .||        ||  ||.:|:........:||..|||||..:..:.|||::.:|.|...|
Human   290 TLLDATYK--------DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE 346

  Fly   334 IGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPED-PKYFIAKG-TIV 396
            ...|.|::....||:.:|::..|::.:.||||..|.:..:.||..|   |:. ..|.|..| .:.
Human   347 QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMART---PQTVAGYTIPPGHQVC 408

  Fly   397 VIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYL 461
            |.|.:.... .|.:.|...|.|:|:..:..|:.....::|||.|...|||..|..:|.....:.:
Human   409 VSPTVNQRL-KDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTM 472

  Fly   462 IRGYKFSV 469
            :|.|:|.:
Human   473 LRLYEFDL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	103/462 (22%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	96/430 (22%)