Protein Alignment Cyp6a17 and CYP4B1

DIOPT Version :9

• Sequence 1: NP_001286433.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 128/536 - (23%)
• Similarity: 225/536 - (41%)
• Gaps: 89/536 - (16%)

  Fly     4 LALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFR----DYYFKYKN 64
            |.|::..|.|:....||:.........|....|.|||         |..||..    |....:.:
Human    20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFG---------HALEIQETGSLDKVVSWAH 75

  Fly    65 SDYPFA-----GFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDP------------ 112
             .:|:|     |.|..|..   :.:.:..|.|.        :||       ||
Human    76 -QFPYAHPLWFGQFIGFLN---IYEPDYAKAVY--------SRG-------DPKAPDVYDFFLQW 121

  Fly   113 LSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSK--TAADRGQVLEVVD 175
            :...|..:||.||...|..|||.|....:|   |.|. |..|..::...|  ..|..|:..::..
Human   122 IGRGLLVLEGPKWLQHRKLLTPGFHYDVLK---PYVA-VFTESTRIMLDKWEEKAREGKSFDIFC 182

  Fly   176 LVARYTADVIGNCAFG--------LNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLS 232
            .|.....:.:..|.||        ...:|.|...::...:.::.:...:|.|  |...:..|...
Human   183 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN--DFIYWLTPHGR 245

  Fly   233 RRLRLKLNIQEAEDFYTKIVRE----TIDYRLRTK---EKRNDFMDSLIEMYKNEQSGNSEDGLT 290
            |.||.   .|.|.|...:::||    ..|.::|.|   .:..||:|.|:       ....||.:.
Human   246 RFLRA---CQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILL-------GARDEDDIK 300

  Fly   291 FN--ELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEM 353
            .:  :|.|:...|...|.:|:::.:.:.||.:|...:.|.:.|||:..:.|..: .|.::.:.:|
Human   301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD-FFQWDDLGKM 364

  Fly   354 KYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKP 418
            .||...:.|:.|.||.:..:.|......:..|.:...| |:::.:....:|.:..::|:||:|..
Human   365 TYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA-GSLISMHIYALHRNSAVWPDPEVFDS 428

  Fly   419 ERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKN 483
            .||:.|..:.|....::||..|||||||.:|.|.:..|..|..:..::||:.| :::|:|  :..
Human   429 LRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDP-SRLPIK--MPQ 490

  Fly   484 ILISAENGIHLKVEKL 499
            :::.::||.||.::.|
Human   491 LVLRSKNGFHLHLKPL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	115/481 (24%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	119/502 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810