Protein Alignment Cyp6a17 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 176/506 - (34%)
• Similarity: 281/506 - (55%)
• Gaps: 35/506 - (6%)

  Fly     2 LLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSD 66
            ||||:.:|:|.|.   ..|.||.::|.|||.....||.||:..:  ::.:.:...:.|.||....
Human    13 LLLAVSLVLLYLY---GTRTHGLFKRLGIPGPTPLPLLGNVLSY--RQGLWKFDTECYKKYGKMW 72

  Fly    67 YPFAGFFFFFTRTAVVTDMELLKRVLIKD-FNHFENRGVFYNEIDDP---LSATLFSIEGQKWRH 127
            ..:.|..    ....:||.::::.||:|: ::.|.||...     .|   :.:.:...|.::|:.
Human    73 GTYEGQL----PVLAITDPDVIRTVLVKECYSVFTNRRSL-----GPVGFMKSAISLAEDEEWKR 128

  Fly   128 LRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGL 192
            :|..|:|||||||:|.||||:.:.|:.:.:..|.:  |::|:.:.:.|:...|:.|||...:||:
Human   129 IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE--AEKGKPVTLKDIFGAYSMDVITGTSFGV 191

  Fly   193 NCNSLYDPKAEFVSIGKRAITEHRYGNM----LDIFLFGF-PKLSRRLRLKLNIQEAEDFYTKIV 252
            |.:||.:|:..||...|:.:   ::|.:    |.|.||.| ..:...|.:.|..::..:|.:|.|
Human   192 NIDSLNNPQDPFVESTKKFL---KFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSV 253

  Fly   253 RETIDYRLRTKEK-RNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMGFA 316
            ......||..|:| |.||:..:|:. :|.:...|...|:..||.||:.||..||:||:|:.:.|.
Human   254 NRMKKSRLNDKQKHRLDFLQLMIDS-QNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 317

  Fly   317 LYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDF 381
            |||||.:.|||.||::||..|. .:....||:.:.:|:||:.||.||||.:||...|.|....|.
Human   318 LYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 381

  Fly   382 SPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIG 446
              |....||.||::||||...:|:||..:.|||.|:||||:.::.:..| ..:.|||.|||||||
Human   382 --EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP-YIYTPFGTGPRNCIG 443

  Fly   447 LRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVE 497
            :||.:|...:.|..:::.:.|....|||||:|:..:. |:..|..|.|||:
Human   444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG-LLQPEKPIVLKVD 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	151/436 (35%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	154/443 (35%)