DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	542	Identity:	137/542 - (25%)
Similarity:	240/542 - (44%)	Gaps:	96/542 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLLALIVVILSLLVFAAR-RRHGYWQRRG---IPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKY 62
            |.:|.::.:|.|||.|.: ..|..|..:.   .|....|..||:.| :...:.:.||....
Mouse    19 LQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHEK-FKGDQELQEIVSCI---- 78

  Fly    63 KNSDYPFAGFFFFFTRTAVVT--DMELLKRVLIKDFNHFENRGVFYNEIDDP------------L 113
              .::|.|...:|:...|.:|  |.:.:|.:|.:               .||            :
Mouse    79 --ENFPSAFPRWFWGSKAYLTVYDPDYMKVILGR---------------SDPKANGAYRLLAPWI 126

  Fly   114 SATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEE----MDKVFRSKTAADRGQVLEVV 174
            ...|..:.||.|...|..|||.|....:|   |.|..:.:.    :||..|   .||:...:|:.
Mouse   127 GYGLLLLNGQPWFQHRRMLTPAFHYDILK---PYVKNMADSIRLMLDKWER---LADQDSSIEIF 185

  Fly   175 DLVARYTADVIGNCAFGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIF------LF----GFP 229
            ..::..|.|.:..|||....:...|        |.........|::.::|      :|    ...
Mouse   186 QHISLMTLDTVMKCAFSHKGSVQVD--------GNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIY 242

  Fly   230 KLSRRLRL-KLNIQEAEDFYTKIVRETIDYRLR--------TKEKRNDFMDSLIEMYKNEQSGNS 285
            |||...|| |...|.|.|....:::...| :|:        .|::|.||:|.|  ::...::|
Mouse   243 KLSSNGRLAKQACQLAHDHTDGVIKLRKD-QLQDEGELEKIKKKRRLDFLDIL--LFARMENG-- 302

  Fly   286 EDGLTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGI 350
             |.::..:|.|:...|...|.:|:::.:.:..|.||.:.|.|.:.|||:.::.| .....|::.:
Mouse   303 -DSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLG-DGSSITWDHL 365

  Fly   351 KEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEI 415
            .::.|....:.|.||.||.:..:.|...|..:..|.: .:.||..|.:...|:|::|.::|.||:
Mouse   366 DQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGR-SLPKGVQVTLSIYGLHHNPKVWPNPEV 429

  Fly   416 FKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGM--MQTCVGLAYLIRGYKFSVSPE-TQIPM 477
            |.|.||..:  :.|.|.::|||..|.|||||.:|.|  ::..|.|..|    :|.:.|: |::||
Mouse   430 FDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLL----RFELLPDPTRVPM 488

  Fly   478 KIVVKNILISAENGIHLKVEKL 499
            .:.  .:::.::|||:|.::||
Mouse   489 PLA--RLVLKSKNGIYLHLKKL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	120/481 (25%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	125/502 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900