Protein Alignment Cyp6a17 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 502
• Identity: 126/502 - (25%)
• Similarity: 217/502 - (43%)
• Gaps: 73/502 - (14%)

  Fly     1 MLLLALIVVILSLL--VFAARRRHGYWQRRGIPHDEVHPLFGNI-----KDWPNKRHIAEIFRDY 58
            :|||...|::...|  .|..|.|..|....|.|....  |.|::     ||....|.:.::|.|:
Mouse     5 LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSF--LLGHLPYFWKKDEDCGRVLQDVFLDW 67

  Fly    59 YFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQ 123
            ..||.    |......|:..:.:||..|.:|:.|:.  ..:......|..:.......||   ||
Mouse    68 AKKYG----PVVRVNVFYKTSVIVTSPESVKKFLMS--TKYNKDSKMYRALQTVFGERLF---GQ 123

  Fly   124 ---------KWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVAR 179
                     :|...|..:...|:...:.::.....:..|::.::..:|  ||....:.:.|::..
Mouse   124 GLVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAK--ADGQTPVSMQDMLTC 186

  Fly   180 YTADVIGNCAFGLNCNSL---YDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLSRRLR--LKL 239
            .|.|::...|||:..:.|   ..|.::.|.:....|:..|  |.|..|:.|..|..|.:|  ::|
Mouse   187 ATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASR--NTLAKFMPGKRKQLREIRESIRL 249

  Fly   240 NIQEAEDFYTKIVRETIDYRLRTKEKRNDFM--DSLIEMYKNEQSGNSEDGLTFNELLAQAFI-F 301
            ..|..:|:.         .|.|...||.:.|  |.|.::.|      :|:|...:|:|...|: |
Mouse   250 LRQVGKDWV---------QRRREALKRGEDMPADILTQILK------AEEGAQDDEVLLDNFVTF 299

  Fly   302 FVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRK 366
            |:||.|||:..:.|.:.||:|..::..:|:.|:..|.|. .:...||.:..::||.||:.|:||.
Mouse   300 FIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGS-KRHLDYEDLGRLQYLSQVLKESLRL 363

  Fly   367 YP-------VLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDE 424
            ||       :|...|.:.........|..|    :..|:..:..:::     :|..|.|:||...
Mouse   364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLF----STYVMGRMDTYFE-----DPLTFNPDRFGPG 419

  Fly   425 EIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSP 471
              |.:|..|:.||..|.|:|||.:|..|:..|.:|.|::..:|.:.|
Mouse   420 --APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	106/430 (25%)
Cyp46a1	NP_034140.1	CYP46A1-like	61..484	CDD:410706	110/444 (25%)