DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and CYP3A7-CYP3A51P

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001243426.2	Gene:	CYP3A7-CYP3A51P / 100861540	HGNCID:	51504	Length:	535	Species:	Homo sapiens

Alignment Length:	512	Identity:	173/512 - (33%)
Similarity:	275/512 - (53%)	Gaps:	51/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSDY--- 67
            |:.|.|.||.....|.||.:::.|||.....|..||          |..||..|:.:....|
Human    14 LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN----------ALSFRKGYWTFDMECYKKY 68

  Fly    68 -PFAGFFFFFTRTAVVTDMELLKRVLIKD-FNHFENR------GVFYNEIDDPLSATLFSI-EGQ 123
             ...|.:........:||.:::|.||:|: ::.|.||      |...|.|         || |.:
Human    69 RKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAI---------SIAEDE 124

  Fly   124 KWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNC 188
            :|:.:|..|:|||||||:|.|.||:.:.|:.:.:..|.:  |:.|:.:.:..:...|:.|||.:.
Human   125 EWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE--AETGKPVTLKHVFGAYSMDVITST 187

  Fly   189 AFGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFG---FPKLSRRLRLKLNI----QEAED 246
            :||::.:||.:|:..||...|:.:   |: |.||.|:..   ||.|:..|. .|||    ::...
Human   188 SFGVSIDSLNNPQDPFVENTKKLL---RF-NPLDPFVLSIKVFPFLTPILE-ALNITVFPRKVIS 247

  Fly   247 FYTKIVRETIDYRLR-TKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSS 310
            |.||.|::..:.||: |::.|.||:..:|:. :|.:...:...|:..||:||:.||..||:||:|
Human   248 FLTKSVKQIKEGRLKETQKHRVDFLQLMIDS-QNSKDSETHKALSDLELMAQSIIFIFAGYETTS 311

  Fly   311 TTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTR 375
            :.:.|.:||||.:.|||.|:::||..|. .:....||:.:.:::||:.||.||||.:||...|.|
Human   312 SVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLER 375

  Fly   376 MTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEG 440
            :...|.  |....||.||.:|:||:..:|:||..:.|||.|.||||:.:.........:.|||.|
Human   376 VCKKDV--EINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438

  Fly   441 PRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVE 497
            ||||||:||.::...:.|..:::.:.|....|||||:|:....:|:: |..|.||.|
Human   439 PRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLT-EKPIVLKAE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	155/461 (34%)
CYP3A7-CYP3A51P	NP_001243426.2	p450	39..492	CDD:278495	160/483 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.720