DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a17 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	508	Identity:	163/508 - (32%)
Similarity:	268/508 - (52%)	Gaps:	45/508 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IVVILSLLVF--AARRRHGYWQRRGIPHDEVHPLFGNIKD-----WPNKRHIAEIFRDYYFKYKN 64
            ::::.||:.|  .....||.:::.|||..:..||||.|.:     |       :...|.|.||..
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFDGMW-------KFDEDCYKKYGK 70

  Fly    65 SDYPFAGFFFFFTRTAVVTDMELLKRVLIKD-FNHFENRGVFYNEIDDPLSATLFSI---EGQKW 125
                ..||:........:.|.|::|.||:|: ::.|.||...     .|:.....||   |.::|
Mouse    71 ----IWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTL-----GPVGFLKKSITISEDEEW 126

  Fly   126 RHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAF 190
            :.||..|:|||||||:|.||||:.:.|:.:.:..|.:  .::|:.:.:.|:...|:.|||...:|
Mouse   127 KRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRRE--EEKGEPINMKDIFGAYSMDVITGTSF 189

  Fly   191 GLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFG---FPKLS---RRLRLKLNIQEAEDFYT 249
            |:|.:||.:|:..||...|:.:.    ..:.|.||..   ||.|:   ..|.|.:..:::.:|:.
Mouse   190 GVNIDSLNNPQNPFVQKTKKILK----FKIFDPFLLSTILFPFLTPIYEMLNLSIFPRDSMNFFK 250

  Fly   250 KIVRETIDYRLRTKEK-RNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTM 313
            |.|:.....||.:|:| |.||:..::.. :|.:...|:..|:..|:.|||.||...|::.:||::
Mouse   251 KFVKRMKKERLASKQKNRVDFLQLMMNT-QNSKGQESQKALSDLEMAAQAVIFIFGGYDATSTSI 314

  Fly   314 GFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTD 378
            ...:||||.:.|||.||::||.... .:....||:.:.:|:||:.||.|:||.||....|.|::.
Mouse   315 SLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSK 378

  Fly   379 TDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRN 443
            .|.  |....||.|||:|:||...:|.:|:.:|||:.|.|.||:.|.........::|||.||||
Mouse   379 KDV--EINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYIYMPFGNGPRN 441

  Fly   444 CIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKV 496
            |:.:||.::...:.:..:::.:......|||||:|| .:..:...|..|.|||
Mouse   442 CLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKI-SREPVFQPEKPIILKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	148/457 (32%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	154/480 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720