DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E1 and eif4e

DIOPT Version :9

Sequence 1:	NP_001261626.1	Gene:	eIF4E1 / 45525	FlyBaseID:	FBgn0015218	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001015909.1	Gene:	eif4e / 548663	XenbaseID:	XB-GENE-855435	Length:	214	Species:	Xenopus tropicalis

Alignment Length:	218	Identity:	102/218 - (46%)
Similarity:	137/218 - (62%)	Gaps:	10/218 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VKPK-EDPQETGEPAGNTATTTAPAGDDAVRTEHLYKHPLMNVWTLWYLENDRSKSWEDMQNEIT 108
            |:|: .:||.|.|....|:       .:.|..:...||||.|.|.||:.:||:||:|:.....|:
Frog     4 VEPEGTNPQSTEEEKTETS-------QEIVSPDQYIKHPLQNRWALWFFKNDKSKTWQANLRLIS 61

  Fly   109 SFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRPMWEDAANKQGGRWVITLNKSS-KTDLDNL 172
            .||||||||:|||||:..|.:..|.||||||..|.|||||..||:||||:|||||.. :.|||..
Frog    62 KFDTVEDFWALYNHIQLSSNLMSGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRNDLDRF 126

  Fly   173 WLDVLLCLIGEAFD-HSDQICGAVINIRGKSNKISIWTADGNNEEAALEIGHKLRDALRLGRNNS 236
            ||:.|:|||||:|| :||.:||||:|:|.|.:||:|||.:..|.:|...||...::.|.|.....
Frog   127 WLETLMCLIGESFDEYSDDVCGAVVNVRAKGDKIAIWTTEFENRDAVTHIGKVYKERLGLPAKVV 191

  Fly   237 LQYQLHKDTMVKQGSNVKSIYTL 259
            :.||.|.||..|.||..|:.:.:
Frog   192 IGYQSHADTATKSGSTTKNRFVV 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E1	NP_001261626.1	IF4E	82..239	CDD:366742	83/158 (53%)
eif4e	NP_001015909.1	IF4E	38..194	CDD:279921	81/155 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3317
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3552
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm9344
Panther	1	1.100	-	-	LDO	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110