DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E1 and eif4e2

DIOPT Version :9

Sequence 1:	NP_001261626.1	Gene:	eIF4E1 / 45525	FlyBaseID:	FBgn0015218	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001014815.2	Gene:	eif4e2 / 541523	ZFINID:	ZDB-GENE-050327-59	Length:	236	Species:	Danio rerio

Alignment Length:	211	Identity:	71/211 - (33%)
Similarity:	111/211 - (52%)	Gaps:	24/211 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PKEDPQETGEPAGNTATTT-----AP-AGDDAVRTEHLYKHPLMNVWTLWYLEND-----RSKSW 100
            ||:..:|..:.....|.||     .| ||:          |||...:|.||....     .::|:
Zfish    23 PKDGEKEKNDEEDKEANTTKRKAVVPGAGE----------HPLQYNYTFWYSRRTPGRPASTQSY 77

  Fly   101 EDMQNEITSFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRPMWEDAANKQGGRWVITLNKSS 165
            |....:|.||.:||.||..|:|:..|.::...||:.|||:.|:|||||.|||.||:|:|.|.|..
Zfish    78 EQNIKQIGSFASVEQFWRFYSHMIRPGDLTGHSDFHLFKEGIKPMWEDDANKSGGKWIIRLRKGL 142

  Fly   166 KTDLDNLWLDVLLCLIGEAFDHSDQICGAVINIRGKSNKISIWTADGNNEEAALEIGHKLRDALR 230
            .:   ..|.:::|.::||.|...::|||||:::|.:.:.||||....:::.....|...||..|.
Zfish   143 AS---RCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLN 204

  Fly   231 LGRNNSLQYQLHKDTM 246
            |..|..::|:.|.|::
Zfish   205 LPPNTIMEYKTHTDSI 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E1	NP_001261626.1	IF4E	82..239	CDD:366742	58/161 (36%)
eif4e2	NP_001014815.2	IF4E	54..212	CDD:307672	58/160 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760