DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E1 and eif4eb

DIOPT Version :9

Sequence 1:	NP_001261626.1	Gene:	eIF4E1 / 45525	FlyBaseID:	FBgn0015218	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001007778.1	Gene:	eif4eb / 493617	ZFINID:	ZDB-GENE-041121-14	Length:	216	Species:	Danio rerio

Alignment Length:	226	Identity:	108/226 - (47%)
Similarity:	139/226 - (61%)	Gaps:	13/226 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AAAPAEAKDVKPKEDPQETGEPAGNTATTTAPAGDDAVRTEHLYKHPLMNVWTLWYLENDRSKSW 100
            |.|..|.|....|.:.:.:.|           :..:.|..|...||||.|.|.||:.:||:||:|
Zfish     2 ATAEPEIKSNSCKSEEEISDE-----------SNQEIVSPESYIKHPLQNRWCLWFFKNDKSKTW 55

  Fly   101 EDMQNEITSFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRPMWEDAANKQGGRWVITLNKSS 165
            :.....|:.||||||||:|||||:..|.:..|.||||||..|.|||||..||:||||:|||||..
Zfish    56 QANLRLISKFDTVEDFWALYNHIQLSSNLMSGCDYSLFKDGIEPMWEDERNKRGGRWLITLNKQQ 120

  Fly   166 -KTDLDNLWLDVLLCLIGEAF-DHSDQICGAVINIRGKSNKISIWTADGNNEEAALEIGHKLRDA 228
             |.|||..||:.||||||||| |:||.:||||:|:|.|.:||:|||||..|.||...||...::.
Zfish   121 RKYDLDRFWLETLLCLIGEAFDDYSDDVCGAVVNVRTKGDKIAIWTADYGNREAVTHIGRVYKER 185

  Fly   229 LRLGRNNSLQYQLHKDTMVKQGSNVKSIYTL 259
            |.:..|.::.||.|.||..|.||..|:.:.:
Zfish   186 LGVPMNMTIGYQSHADTATKSGSTTKNKFVV 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E1	NP_001261626.1	IF4E	82..239	CDD:366742	89/158 (56%)
eif4eb	NP_001007778.1	IF4E	40..196	CDD:279921	87/155 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573561
Domainoid	1	1.000	193	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3585
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm6577
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	LDO	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800