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Protein Alignment eIF4E1 and EIF4E3

DIOPT Version :9

Sequence 1:	NP_001261626.1	Gene:	eIF4E1 / 45525	FlyBaseID:	FBgn0015218	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001128123.1	Gene:	EIF4E3 / 317649	HGNCID:	31837	Length:	224	Species:	Homo sapiens

Alignment Length:	241	Identity:	66/241 - (27%)
Similarity:	111/241 - (46%)	Gaps:	40/241 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PTSAAAPAEAKDVKPKEDPQETGEPAGNTATTTAPAGDDAVRTEHLYK-------HPLMNVWTLW 90
            |.:||.||.|:            ||.|:.|...|.|.:..:..:.|..       .||.:.||.|
Human     4 PPAAAPPAGAR------------EPPGSRAAAAAAAPEPPLGLQQLSALQPEPGGVPLHSSWTFW 56

  Fly    91 YLENDRS----KSWEDMQN--EITSFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRPMWEDA 149
            .   |||    .:.|...|  :|.:..||:.|||:||:|.|.:.:.|...|.|.:...||:||:.
Human    57 L---DRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEE 118

  Fly   150 ANKQGGRWVITLNKSSKTDLDNLWLDVLLCLIGEAFDH----SDQICGAVINIRGKSNKISIWTA 210
            :|.:||.|.:.:.|.|.:   .:|.::||..|||.|..    .|::.|..:::|.:.:.:.:|..
Human   119 SNAKGGVWKMKVPKDSTS---TVWKELLLATIGEQFTDCAAADDEVIGVSVSVRDREDVVQVWNV 180

  Fly   211 DGN--NEEAALEIGHKLRDALRLGRNNSLQYQLHKDTMVKQGSNVK 254
            :.:  .|...||   |:.:.|......::.|:.|::....:|...|
Human   181 NASLVGEATVLE---KIYELLPHITFKAVFYKPHEEHHAFEGGRGK 223

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.